{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T07:39:06Z","timestamp":1772264346827,"version":"3.50.1"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":2159,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1093\/nar\/gkq1248","type":"journal-article","created":{"date-parts":[[2010,12,12]],"date-time":"2010-12-12T01:25:34Z","timestamp":1292117134000},"page":"3042-3052","source":"Crossref","is-referenced-by-count":58,"title":["Selective interactions of boundaries with upstream region of Abd-B promoter in Drosophila bithorax complex and role of dCTCF in this process"],"prefix":"10.1093","volume":"39","author":[{"given":"Olga","family":"Kyrchanova","sequence":"first","affiliation":[]},{"given":"Tatiana","family":"Ivlieva","sequence":"additional","affiliation":[]},{"given":"Stepan","family":"Toshchakov","sequence":"additional","affiliation":[]},{"given":"Alexander","family":"Parshikov","sequence":"additional","affiliation":[]},{"given":"Oksana","family":"Maksimenko","sequence":"additional","affiliation":[]},{"given":"Pavel","family":"Georgiev","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2010,12,10]]},"reference":[{"key":"key\n\t\t\t\t20170510162405_B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(09)88001-0","article-title":"The bithorax complex of Drosophila : an exceptional Hox cluster","volume":"88","author":"Maeda","year":"2009","journal-title":"Curr. Top. Dev. Biol."},{"key":"key\n\t\t\t\t20170510162405_B2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/276565a0","article-title":"A gene complex controlling segmentation in Drosophila","volume":"276","author":"Lewis","year":"1978","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510162405_B3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/313108a0","article-title":"Genetic organization of Drosophila bithorax complex","volume":"313","author":"Sanchez-Herrero","year":"1985","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510162405_B4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s000180050125","article-title":"Chromatin domain boundaries in the bithorax complex","volume":"54","author":"Mihaly","year":"1998","journal-title":"Cell Mol. Life Sci."},{"key":"key\n\t\t\t\t20170510162405_B5","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1242\/dev.02323","article-title":"The ABC of the BX-C: the bithorax complex explained","volume":"133","author":"Maeda","year":"2006","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B6","doi-asserted-by":"crossref","first-page":"8398","DOI":"10.1073\/pnas.92.18.8398","article-title":"Complete sequence of the bithorax complex of Drosophila","volume":"92","author":"Martin","year":"1995","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510162405_B7","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1111\/j.1742-4658.2005.04757.x","article-title":"Long-distance interactions between enhancers and promoters. The case of the Abd-B domain of the Drosophila bithorax complex","volume":"272","author":"Sipos","year":"2005","journal-title":"FEBS J."},{"key":"key\n\t\t\t\t20170510162405_B8","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1002\/j.1460-2075.1990.tb07876.x","article-title":"The molecular genetics of the bithorax complex of Drosophila : cis -regulation in the Abdominal-B domain","volume":"9","author":"Celniker","year":"1990","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170510162405_B9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/genetics\/138.2.387","article-title":"Enhancer traps in the Drosophila bithorax complex mark parasegmental domains","volume":"138","author":"McCall","year":"1994","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170510162405_B10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ydbio.2006.02.015","article-title":"Unraveling cis -regulatory mechanisms at the abdominal-A and Abdominal-B genes in the Drosophila bithorax complex","volume":"293","author":"Akbari","year":"2006","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170510162405_B11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0092-8674(85)90014-5","article-title":"The abdominal region of the bithorax complex","volume":"43","author":"Karch","year":"1985","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510162405_B12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev.ge.21.120187.001441","article-title":"The bithorax complex","volume":"21","author":"Duncan","year":"1987","journal-title":"Annu. Rev. Genet."},{"key":"key\n\t\t\t\t20170510162405_B13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1242\/dev.111.2.393","article-title":"Molecular definition of the morphogenetic and regulatory functions and the cis -regulatory elements of the Drosophila Abd-B homeotic gene","volume":"111","author":"Boulet","year":"1991","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1242\/dev.111.2.437","article-title":"Control of the expression of the bithorax complex abdominal-A and Abdominal-B by cis- regulatory regions in Drosophila embryos","volume":"111","author":"Sanchez-Herrero","year":"1991","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ydbio.2005.08.025","article-title":"Multiple promoter targeting sequences exist in Abdominal-B to regulate long-range gene activation","volume":"286","author":"Chen","year":"2005","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170510162405_B16","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1242\/dev.02451","article-title":"Dissecting the regulatory landscape of the Abd-B gene of the bithorax complex","volume":"133","author":"Mihaly","year":"2006","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B17","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/j.1460-2075.1993.tb05785.x","article-title":"Silencers in abdominal-B , a homeotic Drosophila gene","volume":"12","author":"Busturia","year":"1993","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170510162405_B18","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1101\/gad.10.24.3202","article-title":"Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex","volume":"10","author":"Hagstrom","year":"1996","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170510162405_B19","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1242\/dev.124.21.4343","article-title":"A silencer is required for maintenance of transcriptional repression throughout Drosophila development","volume":"124","author":"Busturia","year":"1997","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B20","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/genetics\/146.4.1365","article-title":"A Polycomb and GAGA dependent silencer adjoin the Fab-7 boundary in the Drosophila bithorax complex","volume":"146","author":"Hangstrom","year":"1997","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170510162405_B21","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1242\/dev.124.9.1809","article-title":"In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb -response element","volume":"124","author":"Mihaly","year":"1997","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B22","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1093\/genetics\/153.3.1333","article-title":"The Mcp element from the Drosophila melanogaster bithorax complex mediates long-distance regulatory interactions","volume":"153","author":"Muller","year":"1999","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170510162405_B23","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1242\/dev.126.14.3057","article-title":"Characterization of the transvection mediating region of the Abdominal-B locus in Drosophila","volume":"126","author":"Zhou","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1242\/dev.127.4.779","article-title":"The Fab-8 boundary defines the distal limit of the bithorax complex iab -7 domain and insulates iab -7 from initiation elements and a PRE in the adjacent iab -8 domain","volume":"127","author":"Barges","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B25","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1002\/j.1460-2075.1990.tb07439.x","article-title":"A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation","volume":"9","author":"Gyurkovics","year":"1990","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170510162405_B26","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/j.1460-2075.1993.tb05750.x","article-title":"The bluetail transposon: evidence for independent cis -regulatory domains and domain boundaries in the bithorax complex","volume":"12","author":"Galloni","year":"1993","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170510162405_B27","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1093\/nar\/22.15.3138","article-title":"Mcp and Fab-7: molecular analysis of putative boundaries of cis -regulatory domains in the bithorax complex of Drosophila melanogaster","volume":"22","author":"Karch","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510162405_B28","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1093\/nar\/gkn818","article-title":"Characterization of new regulatory elements within the Drosophila bithorax complex","volume":"36","author":"Perez-LIuch","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510162405_B29","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.ydbio.2008.12.039","article-title":"Genome-wide ChIP analyses reveal important roles for CTCF in Drosophila genome organization","volume":"328","author":"Smith","year":"2009","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170510162405_B30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0955-0674(03)00039-5","article-title":"Genomic insulators: connecting properties to mechanism","volume":"15","author":"Kuhn","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"key\n\t\t\t\t20170510162405_B31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/sj.hdy.6800669","article-title":"Insulators are fundamental components of the eukaryotic genomes","volume":"94","author":"Brasset","year":"2005","journal-title":"Heredity"},{"key":"key\n\t\t\t\t20170510162405_B32","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1139\/o05-054","article-title":"Organizing the genome: enhancers and insulators","volume":"83","author":"Zhao","year":"2005","journal-title":"Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20170510162405_B33","first-page":"1029","article-title":"Insulators of higher eukaryotes: properties, mechanisms of action, and role in transcription regulation","volume":"42","author":"Maksimenko","year":"2006","journal-title":"Genetika"},{"key":"key\n\t\t\t\t20170510162405_B34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.genet.39.073003.113546","article-title":"Chromatin insulators","volume":"40","author":"Valenzuela","year":"2006","journal-title":"Annu. Rev. Genet."},{"key":"key\n\t\t\t\t20170510162405_B35","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.gde.2007.08.005","article-title":"We gather together: insulators and genome organization","volume":"17","author":"Wallace","year":"2007","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20170510162405_B36","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1101\/gad.10.24.3195","article-title":"The Fab-7 element of the bithorax complex attenuates enhancer\u2013promoter interactions in the Drosophila embryo","volume":"10","author":"Zhou","year":"1996","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170510162405_B37","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1534\/genetics.104.029561","article-title":"The enhancer-blocking activity of the Fab-7 boundary from the Drosophila bithorax complex requires GAGA-factor-binding sites","volume":"168","author":"Schweinsberg","year":"2004","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170510162405_B38","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1242\/dev.01343","article-title":"Developmental modulation of Fab-7 boundary function","volume":"131","author":"Schweinsberg","year":"2004","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B39","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1128\/MCB.25.9.3682-3689.2005","article-title":"The Mcp element from the bithorax complex contains an insulator that is capable of pairwise interactions and can facilitate enhancer\u2013promoter communication","volume":"25","author":"Gruzdeva","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170510162405_B40","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1128\/MCB.02203-06","article-title":"Study of the functional interaction between Mcp insulators from the Drosophila bithorax complex: effects of insulator pairing on enhancer\u2013promoter communication","volume":"27","author":"Kyrchanova","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170510162405_B41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1534\/genetics.107.075887","article-title":"New properties of Drosophila Fab-7 insulator","volume":"177","author":"Rodin","year":"2007","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170510162405_B42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/sj.embor.7400334","article-title":"CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator","volume":"6","author":"Moon","year":"2005","journal-title":"EMBO Rep."},{"key":"key\n\t\t\t\t20170510162405_B43","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1371\/journal.pgen.0030112","article-title":"CTCF genomic binding sites in Drosophila and the organization of the bithorax complex","volume":"3","author":"Holohan","year":"2007","journal-title":"PLoS Genetics"},{"key":"key\n\t\t\t\t20170510162405_B44","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1038\/sj.emboj.7601851","article-title":"The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning","volume":"26","author":"Mohan","year":"2007","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170510162405_B45","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1242\/dev.127.18.3981","article-title":"P element homing to the Drosophila bithorax complex","volume":"127","author":"Bender","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B46","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1128\/MCB.00229-08","article-title":"Functional interaction between the Fab-7 and Fab-8 boundaries and the upstream promoter region in the Drosophila Abd-B gene","volume":"28","author":"Kyrchanova","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170510162405_B47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0092-8674(84)90534-8","article-title":"Analysis of P transposable element functions in Drosophila","volume":"38","author":"Kares","year":"1984","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510162405_B48","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.molcel.2007.09.024","article-title":"Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila","volume":"28","author":"Gerasimova","year":"2007","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170510162405_B49","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0092-8674(89)90033-0","article-title":"The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome","volume":"59","author":"Golic","year":"1989","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510162405_B50","first-page":"487","article-title":"Application of Cre\/loxP in Drosophila . Site-specific recombination and transgene co-placement","volume":"136","author":"Siegal","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t20170510162405_B51","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0092-8674(00)81181-2","article-title":"The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis","volume":"93","author":"Cavalli","year":"1998","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510162405_B52","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1128\/MCB.01622-07","article-title":"A stage-specific factor confers Fab-7 boundary activity during early embryogenesis in Drosophila","volume":"28","author":"Aoki","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170510162405_B53","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/genetics\/149.2.1031","article-title":"Transvection in the Drosophila Abd-B domain: extensive upstream sequences are involved in anchoring distant cis- regulatory regions to the promoter","volume":"149","author":"Sipos","year":"1998","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170510162405_B54","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.gde.2007.08.002","article-title":"Making connections: boundaries and insulators in Drosophila","volume":"17","author":"Maeda","year":"2007","journal-title":"Cur. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20170510162405_B55","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ng1833","article-title":"Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification","volume":"38","author":"Cleard","year":"2006","journal-title":"Nature Genet."},{"key":"key\n\t\t\t\t20170510162405_B56","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1242\/dev.025700","article-title":"Boundary swapping in the Drosophila Bithorax complex","volume":"135","author":"Iampietro","year":"2008","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B57","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0092-8674(00)81546-9","article-title":"A novel cis- regulatory element, the PTS, mediates an anti-insulator activity in the Drosophila embryo","volume":"99","author":"Zhou","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510162405_B58","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1242\/dev.00227","article-title":"The promoter targeting sequence facilitates and restricts a distant enhancer to a single promoter in the Drosophila embryo","volume":"130","author":"Lin","year":"2003","journal-title":"Development"},{"key":"key\n\t\t\t\t20170510162405_B59","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1101\/gad.1230004","article-title":"The promoter targeting sequence mediates epigenetically heritable transcription memory","volume":"18","author":"Lin","year":"2004","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170510162405_B60","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1073\/pnas.0605730104","article-title":"Promoter targeting sequence mediates enhancer interference in the Drosophila embryo","volume":"104","author":"Lin","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510162405_B61","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4161\/fly.5607","article-title":"The Abdominal-B promoter tethering element mediates promoter\u2013enhancer specificity at the Drosophila bithorax complex","volume":"1","author":"Akbari","year":"2007","journal-title":"Fly"},{"key":"key\n\t\t\t\t20170510162405_B62","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1242\/dev.010744","article-title":"A novel promoter-tethering element regulates enhancer-driven gene expression at the bithorax complex in the Drosophila embryo","volume":"135","author":"Akbari","year":"2008","journal-title":"Development"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/39\/8\/3042\/16782714\/gkq1248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T09:42:20Z","timestamp":1636969340000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkq1248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,10]]},"references-count":62,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,12,10]]},"published-print":{"date-parts":[[2011,4]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkq1248","relation":{},"ISSN":["1362-4962","0305-1048"],"issn-type":[{"value":"1362-4962","type":"electronic"},{"value":"0305-1048","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12,10]]}}}