{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:40:24Z","timestamp":1769240424781,"version":"3.49.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":2008,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nucleic Acids Research"],"published-print":{"date-parts":[[2012,1,1]]},"DOI":"10.1093\/nar\/gkr929","type":"journal-article","created":{"date-parts":[[2011,11,13]],"date-time":"2011-11-13T02:04:15Z","timestamp":1321149855000},"page":"D829-D833","source":"Crossref","is-referenced-by-count":92,"title":["HotRegion: a database of predicted hot spot clusters"],"prefix":"10.1093","volume":"40","author":[{"given":"E.","family":"Cukuroglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gursoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,11,12]]},"reference":[{"issue":"15","key":"1_38125830","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/jcc.21561","volume":"31","author":"Illingworth","year":"2010","journal-title":"Journal of computational chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0192-8651","issn-type":"print"},{"issue":"5807","key":"2_23142534","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1126\/science.1136174","volume":"314","author":"Kim","year":"2006","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"3","key":"3_27934912","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.str.2007.01.007","volume":"15","author":"Keskin","year":"2007","journal-title":"Structure (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1878-4186","issn-type":"print"},{"issue":"3","key":"4_31533024","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.jmb.2008.04.071","volume":"381","author":"Tuncbag","year":"2008","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"11","key":"5_23711915","doi-asserted-by":"publisher","first-page":"4347","DOI":"10.1073\/pnas.0607132104","volume":"104","year":"2007","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"1","key":"6_19688726","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1073\/pnas.0407280102","volume":"102","year":"2005","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"5","key":"7_28782057","doi-asserted-by":"publisher","first-page":"R92","DOI":"10.1186\/gb-2007-8-5-r92","volume":"8","author":"Del Sol","year":"2007","journal-title":"Genome biology","ISSN":"https:\/\/id.crossref.org\/issn\/1465-6906","issn-type":"print"},{"issue":"8","key":"8_35267812","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1002\/pro.181","volume":"18","author":"Tyagi","year":"2009","journal-title":"Protein Science","ISSN":"https:\/\/id.crossref.org\/issn\/0961-8368","issn-type":"print"},{"issue":"5","key":"9_18645482","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/j.jmb.2004.10.077","volume":"345","author":"Keskin","year":"2005","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"6","key":"10_37585678","doi-asserted-by":"publisher","first-page":"e1000821","DOI":"10.1371\/journal.pcbi.1000821","volume":"6","author":"Martin","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"issue":"2","key":"11_19477640","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1088\/1478-3975\/2\/2\/S03","volume":"2","author":"Keskin","year":"2005","ISSN":"https:\/\/id.crossref.org\/issn\/1478-3967","issn-type":"print"},{"issue":"3","key":"12_17002698","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/prot.10085","volume":"47","author":"Chakrabarti","year":"2002","journal-title":"Proteins","ISSN":"https:\/\/id.crossref.org\/issn\/0887-3585","issn-type":"print"},{"issue":"7","key":"13_34190864","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1002\/pmic.200800425","volume":"9","author":"Carbonell","year":"2009","journal-title":"Proteomics","ISSN":"https:\/\/id.crossref.org\/issn\/1615-9853","issn-type":"print"},{"issue":"8","key":"14_29306599","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1371\/journal.pcbi.0030164","volume":"3","author":"Humphris","year":"2007","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"issue":"26","key":"15_22297708","doi-asserted-by":"publisher","first-page":"9867","DOI":"10.1073\/pnas.0600220103","volume":"103","year":"2006","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"6","key":"16_18274133","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.str.2004.04.009","volume":"12","author":"Halperin","year":"2004","journal-title":"Structure (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1878-4186","issn-type":"print"},{"issue":"1","key":"17_6066268","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/jmbi.1998.1843","volume":"280","author":"Bogan","year":"1998","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"5196","key":"18_15734004","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1126\/science.7529940","volume":"267","author":"Clackson","year":"1995","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"19_9724206","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0076-6879(91)02020-A","volume":"202","author":"Wells","year":"1991","journal-title":"Methods in enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/0076-6879","issn-type":"print"},{"issue":"43","key":"20_19691170","doi-asserted-by":"publisher","first-page":"15447","DOI":"10.1073\/pnas.0505425102","volume":"102","year":"2005","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"21_29612745","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1741-7007-5-43","volume":"5","author":"Shulman-Peleg","year":"2007","ISSN":"https:\/\/id.crossref.org\/issn\/1741-7007","issn-type":"print"},{"issue":"6","key":"22_37213477","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1007\/s10439-010-0048-9","volume":"38","author":"Cukuroglu","year":"2010","journal-title":"Annals of biomedical engineering","ISSN":"https:\/\/id.crossref.org\/issn\/0090-6964","issn-type":"print"},{"issue":"suppl_2","key":"23_37254633","doi-asserted-by":"publisher","first-page":"W398","DOI":"10.1093\/nar\/gkq360","volume":"38","year":"2010","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"1","key":"24_11065500","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1006\/jmbi.2000.4474","volume":"307","author":"Armon","year":"2001","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"9","key":"25_34960398","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10822-009-9282-3","volume":"23","author":"Guharoy","year":"2009","journal-title":"Journal of computer-aided molecular design","ISSN":"https:\/\/id.crossref.org\/issn\/0920-654X","issn-type":"print"},{"issue":"suppl_1","key":"26_29761207","doi-asserted-by":"publisher","first-page":"D662","DOI":"10.1093\/nar\/gkm813","volume":"36","year":"2008","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"22","key":"27_19674132","doi-asserted-by":"publisher","first-page":"14116","DOI":"10.1073\/pnas.202485799","volume":"99","year":"2002","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"suppl_2","key":"28_37215243","doi-asserted-by":"publisher","first-page":"W402","DOI":"10.1093\/nar\/gkq323","volume":"38","year":"2010","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"9","key":"29_40296344","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1002\/prot.23094","volume":"79","author":"Zhu","year":"2011","journal-title":"Proteins","ISSN":"https:\/\/id.crossref.org\/issn\/0887-3585","issn-type":"print"},{"issue":"suppl_2","key":"30_31036908","doi-asserted-by":"publisher","first-page":"W260","DOI":"10.1093\/nar\/gkn185","volume":"36","year":"2008","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"1","key":"31_6399241","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"4","key":"32_18107493","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1110\/ps.03484604","volume":"13","author":"Keskin","year":"2004","journal-title":"Protein Science","ISSN":"https:\/\/id.crossref.org\/issn\/0961-8368","issn-type":"print"},{"issue":"4","key":"33_16321395","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1006\/jmbi.1996.0424","volume":"260","author":"Tsai","year":"1996","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"12","key":"34_34541403","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1093\/bioinformatics\/btp240","volume":"25","year":"2009","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"4","key":"35_22355411","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/bmb.2006.494034042644","volume":"34","author":"Herraez","year":"2006","journal-title":"Biochemistry and Molecular Biology Education","ISSN":"https:\/\/id.crossref.org\/issn\/1539-3429","issn-type":"print"},{"issue":"10","key":"36_11349652","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/S0968-0004(01)01941-7","volume":"26","author":"Kleanthous","year":"2001","journal-title":"Trends in biochemical sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0167-7640","issn-type":"print"},{"issue":"22","key":"37_37269038","doi-asserted-by":"publisher","first-page":"10080","DOI":"10.1073\/pnas.0910756107","volume":"107","year":"2010","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T14:42:38Z","timestamp":1522680158000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkr929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,12]]},"references-count":37,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2011,12,22]]},"published-print":{"date-parts":[[2012,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkr929","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,12]]}}}