{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:29:31Z","timestamp":1787009371719,"version":"build-2736575974"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":2010,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nucleic Acids Research"],"published-print":{"date-parts":[[2012,1,1]]},"DOI":"10.1093\/nar\/gkr996","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T21:44:06Z","timestamp":1320961446000},"page":"D935-D939","source":"Crossref","is-referenced-by-count":232,"title":["SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants"],"prefix":"10.1093","volume":"40","author":[{"given":"G.","family":"De Baets","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Van Durme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Reumers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Maurer-Stroh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vanhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dopazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schymkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"issue":"5","key":"1_39364249","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nrg2958","volume":"12","author":"Alkan","year":"2011","journal-title":"Nature reviews. Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1471-0056","issn-type":"print"},{"issue":"5343","key":"2_5829353","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1126\/science.278.5343.1580","volume":"278","author":"Collins","year":"1997","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"3","key":"3_23726913","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/sj.clpt.6100087","volume":"81","author":"Giacomini","year":"2007","journal-title":"Clinical pharmacology and therapeutics","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9236","issn-type":"print"},{"issue":"9-10","key":"4_37692603","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.drudis.2010.03.004","volume":"15","author":"Foot","year":"2010","journal-title":"Drug discovery today","ISSN":"https:\/\/id.crossref.org\/issn\/1359-6446","issn-type":"print"},{"issue":"13","key":"5_39960447","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1093\/bioinformatics\/btr295","volume":"27","year":"2011","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"7","key":"6_35207487","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/nprot.2009.86","volume":"4","author":"Kumar","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1750-2799","issn-type":"print"},{"issue":"5","key":"7_6569140","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0168-9525(00)01988-0","volume":"16","author":"Sunyaev","year":"2000","journal-title":"Trends in genetics : TIG","ISSN":"https:\/\/id.crossref.org\/issn\/0168-9525","issn-type":"print"},{"key":"8_38540725","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1186\/1471-2105-11-548","volume":"11","author":"Venselaar","year":"2010","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"issue":"4","key":"9_37024609","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"Adzhubei","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1548-7091","issn-type":"print"},{"issue":"11","key":"10_28759304","doi-asserted-by":"publisher","first-page":"3823","DOI":"10.1093\/nar\/gkm238","volume":"35","year":"2007","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"suppl_2","key":"11_18952241","doi-asserted-by":"publisher","first-page":"W306","DOI":"10.1093\/nar\/gki375","volume":"33","author":"Capriotti","year":"2005","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"7356","key":"12_40389298","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nature10317","volume":"475","author":"Hartl","year":"2011","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"7247","key":"13_35005370","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/nature08009","volume":"459","author":"Tokuriki","year":"2009","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"suppl_2","key":"14_18952257","doi-asserted-by":"publisher","first-page":"W382","DOI":"10.1093\/nar\/gki387","volume":"33","author":"Schymkowitz","year":"2005","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"10","key":"15_18462435","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/nbt1012","volume":"22","author":"Fernandez-Escamilla","year":"2004","journal-title":"Nature biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"3","key":"16_36637793","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nmeth.1432","volume":"7","author":"Maurer-Stroh","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1548-7091","issn-type":"print"},{"issue":"8","key":"17_35489022","doi-asserted-by":"publisher","first-page":"e1000475","DOI":"10.1371\/journal.pcbi.1000475","volume":"5","author":"Van Durme","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"key":"18_34379675","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1146\/annurev.biochem.052308.114844","volume":"78","author":"Powers","year":"2009","journal-title":"Annual review of biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4154","issn-type":"print"},{"issue":"3","key":"19_18725522","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jmb.2005.01.044","volume":"347","author":"Torrance","year":"2005","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"3","key":"20_11019819","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","volume":"305","author":"Krogh","year":"2001","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"suppl_1","key":"21_32444912","doi-asserted-by":"publisher","first-page":"D229","DOI":"10.1093\/nar\/gkn808","volume":"37","year":"2009","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"suppl_1","key":"22_35997997","doi-asserted-by":"publisher","first-page":"D211","DOI":"10.1093\/nar\/gkp985","volume":"38","year":"2010","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"1","key":"23_10759855","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0968-0004(98)01336-X","volume":"24","author":"Nakai","year":"1999","journal-title":"Trends in biochemical sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0167-7640","issn-type":"print"},{"issue":"3","key":"24_17594991","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0022-2836(03)00319-X","volume":"328","author":"Neuberger","year":"2003","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"4","key":"25_17009066","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1006\/jmbi.2002.5426","volume":"317","author":"Maurer-Stroh","year":"2002","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"6","key":"26_18926797","doi-asserted-by":"publisher","first-page":"R55","DOI":"10.1186\/gb-2005-6-6-r55","volume":"6","author":"Maurer-Stroh","year":"2005","journal-title":"Genome biology","ISSN":"https:\/\/id.crossref.org\/issn\/1465-6906","issn-type":"print"},{"issue":"3","key":"27_10975744","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1006\/jmbi.1999.3069","volume":"292","author":"Eisenhaber","year":"1999","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"1","key":"28_10309081","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"1","key":"29_6399241","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"17","key":"30_22336643","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1093\/bioinformatics\/btl348","volume":"22","year":"2006","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"suppl_1","key":"31_18802138","doi-asserted-by":"publisher","first-page":"D527","DOI":"10.1093\/nar\/gki086","volume":"33","author":"Reumers","year":"2005","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"suppl_1","key":"32_30084180","doi-asserted-by":"publisher","first-page":"D825","DOI":"10.1093\/nar\/gkm979","volume":"36","year":"2008","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T10:39:49Z","timestamp":1522665589000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkr996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,10]]},"references-count":32,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2011,12,22]]},"published-print":{"date-parts":[[2012,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkr996","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,10]]}}}