{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:47:12Z","timestamp":1781002032037,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":1405,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/nar\/gks1049","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T20:47:28Z","timestamp":1354308448000},"page":"D764-D772","source":"Crossref","is-referenced-by-count":349,"title":["BRENDA in 2013: integrated reactions, kinetic data, enzyme function data, improved disease classification: new options and contents in BRENDA"],"prefix":"10.1093","volume":"41","author":[{"given":"Ida","family":"Schomburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Placzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"S\u00f6hngen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rother","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Munaretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Ulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Grote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Scheer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Schomburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"key\n\t\t\t\t20171013074436_gks1049-B1","doi-asserted-by":"crossref","first-page":"D507","DOI":"10.1093\/nar\/gkq968","article-title":"The BRENDA Tissue Ontology (BTO): the first all-integrating ontology of all organisms for enzyme source","volume":"39","author":"Gremse","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B2","doi-asserted-by":"crossref","first-page":"D396","DOI":"10.1093\/nar\/gkn803","article-title":"The GOA database in 2009 \u2013 an integrated Gene Ontology Annotation resource","volume":"37","author":"Barrell","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-1-61779-364-6_19","article-title":"A database for chemical proteomics: ChEBI","volume":"803","author":"de Matos","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B4","doi-asserted-by":"crossref","first-page":"D13","DOI":"10.1093\/nar\/gkr1184","article-title":"Database resources of the National Center for Biotechnology Information","volume":"40","author":"Sayers","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B5","doi-asserted-by":"crossref","first-page":"D593","DOI":"10.1093\/nar\/gkn582","article-title":"ExplorEnz: the primary source of the IUBMB enzyme list","volume":"37","author":"McDonald","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B6","first-page":"1151","article-title":"IUPAC-IUBMB Joint Commission on Biochemical Nomenclature (JCBN) and Nomenclature Committee of IUBMB (NC-IUBMB)","volume":"43","author":"Li\u00e9becq","year":"1997","journal-title":"Biochem. Mol. Biol. Int."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B7","doi-asserted-by":"crossref","first-page":"D136","DOI":"10.1093\/nar\/gkr1178","article-title":"The NCBI Taxonomy database","volume":"40","author":"Federhen","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B8","doi-asserted-by":"crossref","first-page":"D588","DOI":"10.1093\/nar\/gkn820","article-title":"BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009","volume":"37","author":"Chang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/1471-2105-12-329","article-title":"Development of a classification scheme for disease-related enzyme information","volume":"12","author":"S\u00f6hngen","year":"2011","journal-title":"BMC Bioinform."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B10","doi-asserted-by":"crossref","first-page":"W695","DOI":"10.1093\/nar\/gkq313","article-title":"A new bioinformatics analysis tools framework at EMBL-EBI","volume":"38","author":"Goujon","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B11","doi-asserted-by":"crossref","first-page":"D84","DOI":"10.1093\/nar\/gkr991","article-title":"Ensembl 2012","volume":"40","author":"Flicek","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/nar\/28.1.45","article-title":"The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000","volume":"28","author":"Bairoch","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B13","doi-asserted-by":"crossref","first-page":"D71","DOI":"10.1093\/nar\/gkr981","article-title":"Reorganizing the protein space at the Universal Protein Resource (UniProt)","volume":"40","author":"UniProt Consortium","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2105-4-41","article-title":"The COG database: an updated version includes eukaryotes","volume":"4","author":"Tatusov","year":"2003","journal-title":"BMC Bioinform."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-61779-400-1_2","article-title":"The KEGG databases and tools facilitating omics analysis: latest developments involving human diseases and pharmaceuticals","volume":"802","author":"Kotera","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B16","doi-asserted-by":"crossref","first-page":"D392","DOI":"10.1093\/nar\/gkq1021","article-title":"The RCSB Protein Data Bank: redesigned web site and web services","volume":"39","author":"Rose","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B17","doi-asserted-by":"crossref","first-page":"D742","DOI":"10.1093\/nar\/gkr1014","article-title":"The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway\/genome databases","volume":"40","author":"Caspi","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2091-12-42","article-title":"BKM-react, an integrated biochemical reaction database","volume":"12","author":"Lang","year":"2011","journal-title":"BMC Biochem."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/1471-2105-12-376","article-title":"EnzymeDetector: an integrated enzyme function prediction tool and database","volume":"12","author":"Quester","year":"2011","journal-title":"BMC Bioinform."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B20","doi-asserted-by":"crossref","first-page":"W597","DOI":"10.1093\/nar\/gks400","article-title":"ExPASy: SIB bioinformatics resource portal","volume":"40","author":"Artimo","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B21","doi-asserted-by":"crossref","first-page":"D434","DOI":"10.1093\/nar\/gkh119","article-title":"IntEnz, the integrated relational enzyme database","volume":"32","author":"Fleischmann","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B22","doi-asserted-by":"crossref","first-page":"D343","DOI":"10.1093\/nar\/gkr987","article-title":"MEROPS: the database of proteolytic enzymes, their substrates and inhibitors","volume":"40","author":"Rawlings","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B23","doi-asserted-by":"crossref","first-page":"D118","DOI":"10.1093\/nar\/gkn710","article-title":"MODOMICS: a database of RNA modification pathways. 2008 update","volume":"37","author":"Czerwoniec","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B24","doi-asserted-by":"crossref","first-page":"D233","DOI":"10.1093\/nar\/gkn663","article-title":"The Carbohydrate-Active EnZymes database (CAZy): an expert resource for glycogenomics","volume":"37","author":"Cantarel","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B25","doi-asserted-by":"crossref","first-page":"D244","DOI":"10.1093\/nar\/gkn834","article-title":"Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases","volume":"37","author":"Martin","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/bmb.2006.494034042644","article-title":"Biomolecules in the computer: Jmol to the rescue","volume":"34","author":"Herr\u00e1ez","year":"2006","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B27","doi-asserted-by":"crossref","first-page":"D670","DOI":"10.1093\/nar\/gkq1089","article-title":"BRENDA, the enzyme information system in 2011","volume":"39","author":"Scheer","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B28","first-page":"175","article-title":"A hidden Markov model for predicting transmembrane helices in protein sequences","volume-title":"Proceedings of the Sixth International Conference on Intelligent Systems for Molecular Biology","author":"Sonnhammer","year":"1998"},{"key":"key\n\t\t\t\t20171013074436_gks1049-B29","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/1471-2105-11-375","article-title":"KID \u2013 an algorithm for fast and efficient text mining used to automatically generate a database containing kinetic information of enzymes","volume":"11","author":"Heinen","year":"2010","journal-title":"BMC Bioinform."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B30","first-page":"131","article-title":"An open standard for chemical structure representation: the IUPAC chemical identifier","volume-title":"Proceedings of the 2003 International Chemical Information Conference","author":"Stein","year":"2003"},{"key":"key\n\t\t\t\t20171013074436_gks1049-B31","doi-asserted-by":"crossref","first-page":"D207","DOI":"10.1093\/nar\/gkg005","article-title":"The PEDANT genome database","volume":"31","author":"Frishman","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B32","doi-asserted-by":"crossref","first-page":"D408","DOI":"10.1093\/nar\/gkn749","article-title":"PEDANT covers all complete RefSeq genomes","volume":"37","author":"Walter","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B33","doi-asserted-by":"crossref","first-page":"D483","DOI":"10.1093\/nar\/gkn861","article-title":"Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes","volume":"37","author":"Winsor","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013074436_gks1049-B34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1186\/1471-2105-11-589","article-title":"BrEPS: a flexible and automatic protocol to compute enzyme-specific sequence profiles for functional annotation","volume":"11","author":"Bannert","year":"2010","journal-title":"BMC Bioinform."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/41\/D1\/D764\/3595689\/gks1049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T10:39:54Z","timestamp":1522665594000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/nar\/article\/41\/D1\/D764\/1052948\/BRENDA-in-2013-integrated-reactions-kinetic-data"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,29]]},"references-count":34,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2012,11,29]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gks1049","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,29]]}}}