{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:35:56Z","timestamp":1775151356810,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":743,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,28]]},"DOI":"10.1093\/nar\/gku1043","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T02:09:58Z","timestamp":1414548598000},"page":"D43-D47","source":"Crossref","is-referenced-by-count":61,"title":["euL1db: the European database of L1HS retrotransposon insertions in humans"],"prefix":"10.1093","volume":"43","author":[{"given":"Ashfaq A.","family":"Mir","sequence":"first","affiliation":[]},{"given":"Claude","family":"Philippe","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-3091","authenticated-orcid":false,"given":"Ga\u00ebl","family":"Cristofari","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2014,10,28]]},"reference":[{"key":"key\n\t\t\t\t20171011200809_B1","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1073\/pnas.0831042100","article-title":"Hot L1s account for the bulk of retrotransposition in the human population","volume":"100","author":"Brouha","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20171011200809_B2","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.cell.2012.04.019","article-title":"Human transposon tectonics","volume":"149","author":"Burns","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.gde.2012.02.006","article-title":"Active human retrotransposons: variation and disease","volume":"22","author":"Hancks","year":"2012","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20171011200809_B4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-genom-082509-141802","article-title":"LINE-1 elements in structural variation and disease","volume":"12","author":"Beck","year":"2011","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"key\n\t\t\t\t20171011200809_B5","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1093\/emboj\/16.19.6034","article-title":"Sequence-specific single-strand RNA binding protein encoded by the human LINE-1 retrotransposon","volume":"16","author":"Hohjoh","year":"1997","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20171011200809_B6","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1126\/science.1722352","article-title":"Reverse transcriptase encoded by a human transposable element","volume":"254","author":"Mathias","year":"1991","journal-title":"Science"},{"key":"key\n\t\t\t\t20171011200809_B7","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0092-8674(00)81997-2","article-title":"Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition","volume":"87","author":"Feng","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nsmb1107","article-title":"Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles","volume":"13","author":"Kulpa","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"key\n\t\t\t\t20171011200809_B9","doi-asserted-by":"crossref","first-page":"e1001150","DOI":"10.1371\/journal.pgen.1001150","article-title":"Characterization of LINE-1 ribonucleoprotein particles","volume":"6","author":"Doucet","year":"2010","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20171011200809_B10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0092-8674(93)90078-5","article-title":"Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition","volume":"72","author":"Luan","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B11","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1093\/emboj\/cdf592","article-title":"Human L1 element target-primed reverse transcription in vitro","volume":"21","author":"Cost","year":"2002","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20171011200809_B12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0092-8674(02)00828-0","article-title":"Genomic deletions created upon LINE-1 retrotransposition","volume":"110","author":"Gilbert","year":"2002","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0092-8674(02)00839-5","article-title":"Human l1 retrotransposition is associated with genetic instability in vivo","volume":"110","author":"Symer","year":"2002","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B14","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1101\/gr.205701","article-title":"Twin priming: a proposed mechanism for the creation of inversions in L1 retrotransposition","volume":"11","author":"Ostertag","year":"2001","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20171011200809_B15","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1126\/science.283.5407.1530","article-title":"Exon shuffling by L1 retrotransposition","volume":"283","author":"Moran","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20171011200809_B16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/hmg\/9.4.653","article-title":"Transduction of 3\u2032-flanking sequences is common in L1 retrotransposition","volume":"9","author":"Goodier","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20171011200809_B17","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1093\/nar\/gkm516","article-title":"Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease","volume":"35","author":"Repanas","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171011200809_B18","doi-asserted-by":"crossref","first-page":"e1003499","DOI":"10.1371\/journal.pgen.1003499","article-title":"The specificity and flexibility of L1 reverse transcription priming at imperfect T-tracts","volume":"9","author":"Monot","year":"2013","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20171011200809_B19","doi-asserted-by":"crossref","first-page":"e28907","DOI":"10.4161\/mge.28907","article-title":"L1 retrotransposition: the snap-velcro model and its consequences","volume":"4","author":"Viollet","year":"2014","journal-title":"Mob. Genet. Elem."},{"key":"key\n\t\t\t\t20171011200809_B20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1759-8753-1-21","article-title":"Mobilizing diversity: transposable element insertions in genetic variation and disease","volume":"1","author":"O'Donnell","year":"2010","journal-title":"Mob. DNA"},{"key":"key\n\t\t\t\t20171011200809_B21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1101\/gr.110528.110","article-title":"Reading TE leaves: new approaches to the identification of transposable element insertions","volume":"21","author":"Ray","year":"2011","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20171011200809_B22","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1101\/gr.114777.110","article-title":"Whole-genome resequencing allows detection of many rare LINE-1 insertion alleles in humans","volume":"21","author":"Ewing","year":"2011","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20171011200809_B23","doi-asserted-by":"crossref","first-page":"e1002236","DOI":"10.1371\/journal.pgen.1002236","article-title":"A comprehensive map of mobile element insertion polymorphisms in humans","volume":"7","author":"Stewart","year":"2011","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20171011200809_B24","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.cell.2010.05.021","article-title":"LINE-1 retrotransposition activity in human genomes","volume":"141","author":"Beck","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B25","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.cell.2010.05.026","article-title":"Mobile interspersed repeats are major structural variants in the human genome","volume":"141","author":"Huang","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B26","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.cell.2010.05.020","article-title":"Natural mutagenesis of human genomes by endogenous retrotransposons","volume":"141","author":"Iskow","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B27","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1101\/gr.106419.110","article-title":"High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes","volume":"20","author":"Ewing","year":"2010","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20171011200809_B28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/332164a0","article-title":"Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man","volume":"332","author":"Kazazian","year":"1988","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171011200809_B29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.gene.2013.01.008","article-title":"Retroelements in human disease","volume":"518","author":"Kaer","year":"2013","journal-title":"Gene"},{"key":"key\n\t\t\t\t20171011200809_B30","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/nature08248","article-title":"L1 retrotransposition in human neural progenitor cells","volume":"460","author":"Coufal","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171011200809_B31","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature10531","article-title":"Somatic retrotransposition alters the genetic landscape of the human brain","volume":"479","author":"Baillie","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171011200809_B32","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2012.09.035","article-title":"Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain","volume":"151","author":"Evrony","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cell.2013.02.032","article-title":"Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma","volume":"153","author":"Shukla","year":"2013","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011200809_B34","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1101\/gr.145235.112","article-title":"Extensive somatic L1 retrotransposition in colorectal tumors","volume":"22","author":"Solyom","year":"2012","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20171011200809_B35","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1222077","article-title":"Landscape of somatic retrotransposition in human cancers","volume":"337","author":"Lee","year":"2012","journal-title":"Science"},{"key":"key\n\t\t\t\t20171011200809_B36","first-page":"643","article-title":"Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer","volume":"52","author":"Miki","year":"1992","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20171011200809_B37","doi-asserted-by":"crossref","first-page":"e1003402","DOI":"10.1371\/journal.pgen.1003402","article-title":"Long interspersed element-1 (LINE-1): passenger or driver in human neoplasms?","volume":"9","author":"Rodi\u0107","year":"2013","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20171011200809_B38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1759-8753-5-11","article-title":"Retrotransposition in tumors and brains","volume":"5","author":"Goodier","year":"2014","journal-title":"Mob. DNA"},{"key":"key\n\t\t\t\t20171011200809_B39","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1101\/gr.163659.113","article-title":"Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing","volume":"24","author":"Helman","year":"2014","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20171011200809_B40","doi-asserted-by":"crossref","first-page":"D764","DOI":"10.1093\/nar\/gkt1168","article-title":"The UCSC genome browser database: 2014 update","volume":"42","author":"Karolchik","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171011200809_B41","doi-asserted-by":"crossref","first-page":"D936","DOI":"10.1093\/nar\/gks1213","article-title":"DbVar and DGVa: public archives for genomic structural variation","volume":"41","author":"Lappalainen","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171011200809_B42","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1159\/000084979","article-title":"Repbase update, a database of eukaryotic repetitive elements","volume":"110","author":"Jurka","year":"2005","journal-title":"Cytogenet. Genome Res."},{"key":"key\n\t\t\t\t20171011200809_B43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/humu.20307","article-title":"dbRIP: a highly integrated database of retrotransposon insertion polymorphisms in humans","volume":"27","author":"Wang","year":"2006","journal-title":"Hum. Mutat."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/43\/D1\/D43\/17058568\/gku1043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T10:41:44Z","timestamp":1522665704000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/nar\/article\/43\/D1\/D43\/2436160\/euL1db-the-European-database-of-L1HS"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,28]]},"references-count":43,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2014,10,28]]},"published-print":{"date-parts":[[2015,1,28]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gku1043","relation":{},"ISSN":["1362-4962","0305-1048"],"issn-type":[{"value":"1362-4962","type":"electronic"},{"value":"0305-1048","type":"print"}],"subject":[],"published-other":{"date-parts":[[2015,1,28]]},"published":{"date-parts":[[2014,10,28]]}}}