{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T01:50:06Z","timestamp":1779241806705,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":364,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nucleic Acids Res"],"published-print":{"date-parts":[[2016,1,4]]},"DOI":"10.1093\/nar\/gkv1230","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T03:29:48Z","timestamp":1447817388000},"page":"D1069-D1074","source":"Crossref","is-referenced-by-count":256,"title":["Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information"],"prefix":"10.1093","volume":"44","author":[{"given":"Hong","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Zong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,11,17]]},"reference":[{"key":"2016021418573646000_44.D1.D1069.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd892"},{"key":"2016021418573646000_44.D1.D1069.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2132"},{"key":"2016021418573646000_44.D1.D1069.3","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.2.4"},{"key":"2016021418573646000_44.D1.D1069.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141478"},{"key":"2016021418573646000_44.D1.D1069.5","doi-asserted-by":"publisher","DOI":"10.1038\/nature10937"},{"key":"2016021418573646000_44.D1.D1069.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2918"},{"key":"2016021418573646000_44.D1.D1069.7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010611-134520"},{"key":"2016021418573646000_44.D1.D1069.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.02.007"},{"key":"2016021418573646000_44.D1.D1069.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2683"},{"key":"2016021418573646000_44.D1.D1069.10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1068"},{"key":"2016021418573646000_44.D1.D1069.11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1129"},{"key":"2016021418573646000_44.D1.D1069.12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1143"},{"key":"2016021418573646000_44.D1.D1069.13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1031"},{"key":"2016021418573646000_44.D1.D1069.14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl999"},{"key":"2016021418573646000_44.D1.D1069.15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1076"},{"key":"2016021418573646000_44.D1.D1069.16","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.581"},{"key":"2016021418573646000_44.D1.D1069.17","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.117"},{"key":"2016021418573646000_44.D1.D1069.18","doi-asserted-by":"crossref","unstructured":"Tao L. Zhu F. Xu F. Chen Z. Jiang Y. Chen Y. Co-targeting cancer drug escape pathways confers clinical advantage for multi-target anticancer drugs. Pharmacol. Res. 2015. In press.","DOI":"10.1016\/j.phrs.2015.09.019"},{"key":"2016021418573646000_44.D1.D1069.19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1103"},{"key":"2016021418573646000_44.D1.D1069.20","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-1-r3"},{"key":"2016021418573646000_44.D1.D1069.21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-175-2_7"},{"key":"2016021418573646000_44.D1.D1069.22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv399"},{"key":"2016021418573646000_44.D1.D1069.23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn653"},{"key":"2016021418573646000_44.D1.D1069.24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1018"},{"key":"2016021418573646000_44.D1.D1069.25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1074"},{"key":"2016021418573646000_44.D1.D1069.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1012065"},{"key":"2016021418573646000_44.D1.D1069.27","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2199"},{"key":"2016021418573646000_44.D1.D1069.28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr797"},{"key":"2016021418573646000_44.D1.D1069.29","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.69"},{"key":"2016021418573646000_44.D1.D1069.30","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1272"},{"key":"2016021418573646000_44.D1.D1069.31","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6888208"},{"key":"2016021418573646000_44.D1.D1069.32","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.149955"},{"key":"2016021418573646000_44.D1.D1069.33","doi-asserted-by":"publisher","DOI":"10.1039\/c2mb25165e"},{"key":"2016021418573646000_44.D1.D1069.34","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.118"},{"key":"2016021418573646000_44.D1.D1069.35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku989"},{"key":"2016021418573646000_44.D1.D1069.36","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3078"},{"key":"2016021418573646000_44.D1.D1069.37","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3405"},{"key":"2016021418573646000_44.D1.D1069.38","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3229"},{"key":"2016021418573646000_44.D1.D1069.39","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3625"},{"key":"2016021418573646000_44.D1.D1069.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00129-0"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/44\/D1\/D1069\/16661700\/gkv1230.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T14:42:46Z","timestamp":1522680166000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkv1230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,17]]},"references-count":40,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2016,1,3]]},"published-print":{"date-parts":[[2016,1,4]]}},"alternative-id":["10.1093\/nar\/gkv1230"],"URL":"https:\/\/doi.org\/10.1093\/nar\/gkv1230","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,17]]}}}