{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:29:41Z","timestamp":1787009381282,"version":"build-2736575974"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,4]]},"DOI":"10.1093\/nar\/gkx1008","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T07:09:57Z","timestamp":1507878597000},"page":"D950-D955","source":"Crossref","is-referenced-by-count":127,"title":["HCMDB: the human cancer metastasis database"],"prefix":"10.1093","volume":"46","author":[{"given":"Guantao","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wushuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"key\n\t\t\t\t20180103185729_B1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s10555-007-9088-5","article-title":"Metastasis: the seed and soil theory gains identity","volume":"26","year":"2007","journal-title":"Cancer Metast. Rev."},{"key":"key\n\t\t\t\t20180103185729_B2","first-page":"211","article-title":"Molecular targets in metastasis: lessons from genomic approaches","volume":"4","year":"2007","journal-title":"Cancer Genomics Proteomics"},{"key":"key\n\t\t\t\t20180103185729_B3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","year":"2000","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180103185729_B4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/283139a0","article-title":"The pathogenesis of cancer metastasis","volume":"283","year":"1980","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180103185729_B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10555-013-9455-3","article-title":"The non-coding transcriptome as a dynamic regulator of cancer metastasis","volume":"33","year":"2014","journal-title":"Cancer Metast. Rev."},{"key":"key\n\t\t\t\t20180103185729_B6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1387\/ijdb.041809ic","article-title":"Novel technologies and recent advances in metastasis research","volume":"48","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"key\n\t\t\t\t20180103185729_B7","first-page":"61","article-title":"Microarrays bring new insights into understanding of breast cancer metastasis to bone","volume":"6","year":"2004","journal-title":"Breast Cancer Res.: BCR"},{"key":"key\n\t\t\t\t20180103185729_B8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10585-011-9438-0","article-title":"Analysis of a bone metastasis gene expression signature in patients with bone metastasis from solid tumors","volume":"29","year":"2012","journal-title":"Clin. Exp. Metast."},{"key":"key\n\t\t\t\t20180103185729_B9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","article-title":"A molecular signature of metastasis in primary solid tumors","volume":"33","year":"2003","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180103185729_B10","first-page":"5679","article-title":"Molecular signature associated with bone marrow micrometastasis in human breast cancer","volume":"63","year":"2003","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20180103185729_B11","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1158\/0008-5472.CAN-15-0997","article-title":"A systematic approach to defining the microRNA landscape in metastasis","volume":"75","year":"2015","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20180103185729_B12","doi-asserted-by":"crossref","first-page":"14421","DOI":"10.1038\/ncomms14421","article-title":"Recurrently deregulated lncRNAs in hepatocellular carcinoma","volume":"8","year":"2017","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20180103185729_B13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1158\/1078-0432.CCR-15-0487","article-title":"Transcriptional profiling of breast cancer metastases identifies liver metastasis-selective genes associated with adverse outcome in luminal a primary breast cancer","volume":"22","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t20180103185729_B14","first-page":"dju492","article-title":"Identification of a metastasis-specific MicroRNA signature in human colorectal cancer","volume":"107","year":"2015","journal-title":"J. Natl. Cancer Inst.e"},{"key":"key\n\t\t\t\t20180103185729_B15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4161\/cc.8.3.7526","article-title":"How epigenetics can explain human metastasis: a new role for microRNAs","volume":"8","year":"2009","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20180103185729_B16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1158\/1078-0432.CCR-16-0395","article-title":"The prediction of clinical outcome in hepatocellular carcinoma based on a six-gene metastasis signature","volume":"23","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t20180103185729_B17","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.18632\/oncotarget.12463","article-title":"Role of long noncoding RNA UCA1 as a common molecular marker for lymph node metastasis and prognosis in various cancers: a meta-analysis","volume":"8","year":"2017","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20180103185729_B18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12943-016-0545-z","article-title":"Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis","volume":"15","year":"2016","journal-title":"Mol. Cancer"},{"key":"key\n\t\t\t\t20180103185729_B19","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.bbamcr.2017.06.003","article-title":"Deep sequencing reveals a global reprogramming of lncRNA transcriptome during EMT","volume":"1864","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20180103185729_B20","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.3748\/wjg.v13.i44.5832","article-title":"Is there a genetic signature for liver metastasis in colorectal cancer","volume":"13","year":"2007","journal-title":"World journal of gastroenterology"},{"key":"key\n\t\t\t\t20180103185729_B21","first-page":"D991","article-title":"NCBI GEO: archive for functional genomics data sets\u2013update","volume":"41","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185729_B22","first-page":"D13","article-title":"Database resources of the National Center for Biotechnology Information","volume":"36","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185729_B23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","year":"2012","journal-title":"Cancer Discov."},{"key":"key\n\t\t\t\t20180103185729_B24","doi-asserted-by":"crossref","first-page":"D944","DOI":"10.1093\/nar\/gkv1282","article-title":"Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"Suppl 4","key":"key\n\t\t\t\t20180103185729_B25","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1471-2164-11-S4-S5","article-title":"dbDEMC: a database of differentially expressed miRNAs in human cancers","volume":"11","year":"2010","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20180103185729_B26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jgg.2017.04.006","article-title":"CMGene: A literature-based database and knowledge resource for cancer metastasis genes","volume":"44","year":"2017","journal-title":"J. Genet. Genomics"},{"key":"key\n\t\t\t\t20180103185729_B27","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","year":"2009","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20180103185729_B28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20180103185729_B29","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185729_B30","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng2135","article-title":"The role of site accessibility in microRNA target recognition","volume":"39","year":"2007","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180103185729_B31","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","article-title":"Human MicroRNA targets","volume":"2","year":"2004","journal-title":"PLoS Biol."},{"key":"key\n\t\t\t\t20180103185729_B32","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gkl243","article-title":"RNAhybrid: microRNA target prediction easy, fast and flexible","volume":"34","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185729_B33","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s10549-011-1846-y","article-title":"Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival","volume":"133","year":"2012","journal-title":"Breast Cancer Res. Treatment"},{"key":"key\n\t\t\t\t20180103185729_B34","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1200\/JCO.2008.19.2542","article-title":"Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome","volume":"27","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"key\n\t\t\t\t20180103185729_B35","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12094-011-0676-z","article-title":"Gene expression signature and response to the use of leucovorin, fluorouracil and oxaliplatin in colorectal cancer patients","volume":"13","year":"2011","journal-title":"Clin. Transl. Oncol."},{"key":"key\n\t\t\t\t20180103185729_B36","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/ijc.25256","article-title":"MUC12 mRNA expression is an independent marker of prognosis in stage II and stage III colorectal cancer","volume":"127","year":"2010","journal-title":"Int. J. Cancer"},{"key":"key\n\t\t\t\t20180103185729_B37","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1186\/1471-2164-14-589","article-title":"Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis","volume":"14","year":"2013","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20180103185729_B38","doi-asserted-by":"crossref","first-page":"e74599","DOI":"10.1371\/journal.pone.0074599","article-title":"Specific extracellular matrix remodeling signature of colon hepatic metastases","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180103185729_B39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10585-012-9532-y","article-title":"S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells","volume":"30","year":"2013","journal-title":"Clin. Exp. Metast."},{"key":"key\n\t\t\t\t20180103185729_B40","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1158\/0008-5472.CAN-15-1364","article-title":"MCAM and LAMA4 are highly enriched in tumor blood vessels of renal cell carcinoma and predict patient outcome","volume":"76","year":"2016","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20180103185729_B41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.molonc.2013.10.002","article-title":"Claudin-2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrences","volume":"8","year":"2014","journal-title":"Mol. Oncol."},{"key":"key\n\t\t\t\t20180103185729_B42","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/1471-2407-10-222","article-title":"A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer","volume":"10","year":"2010","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t20180103185729_B43","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng1167","article-title":"Gene expression phenotypic models that predict the activity of oncogenic pathways","volume":"34","year":"2003","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180103185729_B44","first-page":"95","article-title":"Mechanisms of oncogenic cooperation in cancer initiation and metastasis","volume":"79","year":"2006","journal-title":"Yale J. Biol. Med."},{"key":"key\n\t\t\t\t20180103185729_B45","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.juro.2016.04.061","article-title":"Prediction of lymph node metastasis in patients with bladder cancer using whole transcriptome gene expression signatures","volume":"196","year":"2016","journal-title":"J. Urol."},{"key":"key\n\t\t\t\t20180103185729_B46","doi-asserted-by":"crossref","first-page":"16553","DOI":"10.1038\/srep16553","article-title":"A potential prognostic long non-coding RNA signature to predict metastasis-free survival of breast cancer patients","volume":"5","year":"2015","journal-title":"Scientific Rep."},{"key":"key\n\t\t\t\t20180103185729_B47","doi-asserted-by":"crossref","first-page":"43731","DOI":"10.18632\/oncotarget.6192","article-title":"Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancer","volume":"6","year":"2015","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20180103185729_B48","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1186\/s12864-015-2082-3","article-title":"New global analysis of the microRNA transcriptome of primary tumors and lymph node metastases of papillary thyroid cancer","volume":"16","year":"2015","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20180103185729_B49","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1158\/1078-0432.CCR-15-0143","article-title":"A composite gene expression signature optimizes prediction of colorectal cancer metastasis and outcome","volume":"22","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t20180103185729_B50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ygeno.2014.07.012","article-title":"Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing","volume":"104","year":"2014","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20180103185729_B51","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nature23306","article-title":"Integrative clinical genomics of metastatic cancer","volume":"548","year":"2017","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180103185729_B52","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.18632\/oncotarget.13847","article-title":"Genome wide copy number analyses of superficial esophageal squamous cell carcinoma with and without metastasis","volume":"8","year":"2017","journal-title":"Oncotarget"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/D1\/D950\/23161881\/gkx1008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T17:04:38Z","timestamp":1603127078000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/nar\/article\/46\/D1\/D950\/4566597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,27]]},"references-count":52,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2017,10,27]]},"published-print":{"date-parts":[[2018,1,4]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkx1008","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1,4]]},"published":{"date-parts":[[2017,10,27]]}}}