{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:03:08Z","timestamp":1770904988474,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,4]]},"DOI":"10.1093\/nar\/gkx1077","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T16:51:53Z","timestamp":1508777513000},"page":"D428-D434","source":"Crossref","is-referenced-by-count":181,"title":["The eukaryotic linear motif resource \u2013 2018 update"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9248-8450","authenticated-orcid":false,"given":"Marc","family":"Gouw","sequence":"first","affiliation":[]},{"given":"Sushama","family":"Michael","sequence":"additional","affiliation":[]},{"given":"Hugo","family":"S\u00e1mano-S\u00e1nchez","sequence":"additional","affiliation":[]},{"given":"Manjeet","family":"Kumar","sequence":"additional","affiliation":[]},{"given":"Andr\u00e1s","family":"Zeke","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-8380","authenticated-orcid":false,"given":"Benjamin","family":"Lang","sequence":"additional","affiliation":[]},{"given":"Benoit","family":"Bely","sequence":"additional","affiliation":[]},{"given":"Luc\u00eda B","family":"Chemes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-4850","authenticated-orcid":false,"given":"Norman E","family":"Davey","sequence":"additional","affiliation":[]},{"given":"Ziqi","family":"Deng","sequence":"additional","affiliation":[]},{"given":"Francesca","family":"Diella","sequence":"additional","affiliation":[]},{"given":"Clara-Marie","family":"G\u00fcrth","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-5866","authenticated-orcid":false,"given":"Ann-Kathrin","family":"Huber","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Kleinsorg","sequence":"additional","affiliation":[]},{"given":"Lara S","family":"Schlegel","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-6436","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Palopoli","sequence":"additional","affiliation":[]},{"given":"Kim V","family":"Roey","sequence":"additional","affiliation":[]},{"given":"Brigitte","family":"Altenberg","sequence":"additional","affiliation":[]},{"given":"Attila","family":"Rem\u00e9nyi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9316-5204","authenticated-orcid":false,"given":"Holger","family":"Dinkel","sequence":"additional","affiliation":[]},{"given":"Toby J","family":"Gibson","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"key\n\t\t\t\t20180103185638_B1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1039\/C1MB05231D","article-title":"Attributes of short linear motifs","volume":"8","year":"2012","journal-title":"Mol. Biosyst."},{"key":"key\n\t\t\t\t20180103185638_B2","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1021\/cr400585q","article-title":"Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation","volume":"114","year":"2014","journal-title":"Chem. Rev."},{"key":"key\n\t\t\t\t20180103185638_B3","first-page":"6580","article-title":"Understanding eukaryotic linear motifs and their role in cell signaling and regulation","volume":"13","year":"2008","journal-title":"Front. Biosci."},{"key":"key\n\t\t\t\t20180103185638_B4","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.sbi.2012.03.004","article-title":"Motif switches: decision-making in cell regulation","volume":"22","year":"2012","journal-title":"Curr. Opin. Struct. Biol."},{"key":"key\n\t\t\t\t20180103185638_B5","first-page":"rs7","article-title":"The switches.ELM resource: a compendium of conditional regulatory interaction interfaces","volume":"6","year":"2013","journal-title":"Sci. Signal."},{"key":"key\n\t\t\t\t20180103185638_B6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tibs.2010.10.002","article-title":"How viruses hijack cell regulation","volume":"36","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"key\n\t\t\t\t20180103185638_B7","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1039\/C4MB00290C","article-title":"Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer","volume":"10","year":"2014","journal-title":"Mol. Biosyst."},{"key":"key\n\t\t\t\t20180103185638_B8","doi-asserted-by":"crossref","first-page":"eaak9982","DOI":"10.1126\/scisignal.aak9982","article-title":"Degrons in cancer","volume":"10","year":"2017","journal-title":"Sci. Signal."},{"key":"key\n\t\t\t\t20180103185638_B9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.molcel.2014.05.032","article-title":"A million peptide motifs for the molecular biologist","volume":"55","year":"2014","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180103185638_B10","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1093\/nar\/gkg545","article-title":"ELM server: a new resource for investigating short functional sites in modular eukaryotic proteins","volume":"31","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B11","doi-asserted-by":"crossref","first-page":"D242","DOI":"10.1093\/nar\/gkr1064","article-title":"ELM\u2013the database of eukaryotic linear motifs","volume":"40","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B12","doi-asserted-by":"crossref","first-page":"D259","DOI":"10.1093\/nar\/gkt1047","article-title":"The eukaryotic linear motif resource ELM: 10 years and counting","volume":"42","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B13","doi-asserted-by":"crossref","first-page":"D294","DOI":"10.1093\/nar\/gkv1291","article-title":"ELM 2016\u2019data update and new functionality of the eukaryotic linear motif resource","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B14","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the Gene Ontology knowledgebase and resources","volume":"45","author":"The Gene Ontology Consortium","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1741-7007-5-44","article-title":"Broadening the horizon\u2013level 2.5 of the HUPO-PSI format for molecular interactions","volume":"5","year":"2007","journal-title":"BMC Biol."},{"issue":"Suppl. 1","key":"key\n\t\t\t\t20180103185638_B16","first-page":"5","article-title":"Database resources of the National Center for Biotechnology Information","volume":"37","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B17","doi-asserted-by":"crossref","first-page":"D26","DOI":"10.1093\/nar\/gkn723","article-title":"GenBank","volume":"37","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B19","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1093\/nar\/gkg519","article-title":"GlobPlot: exploring protein sequences for globularity and disorder","volume":"31","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B20","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1093\/bioinformatics\/bti541","article-title":"IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content","volume":"21","year":"2005","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180103185638_B21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/1471-2105-10-351","article-title":"A structure filter for the eukaryotic linear motif resource","volume":"10","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180103185638_B22","doi-asserted-by":"crossref","first-page":"D257","DOI":"10.1093\/nar\/gku949","article-title":"SMART: recent updates, new developments and status in 2015","volume":"43","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B23","doi-asserted-by":"crossref","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","article-title":"The Pfam protein families database: towards a more sustainable future","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B24","doi-asserted-by":"crossref","first-page":"W11","DOI":"10.1093\/nar\/gkw265","article-title":"ProViz-a web-based visualization tool to investigate the functional and evolutionary features of protein sequences","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B25","doi-asserted-by":"crossref","first-page":"W464","DOI":"10.1093\/nar\/gkx238","article-title":"SLiMSearch: a framework for proteome-wide discovery and annotation of functional modules in intrinsically disordered regions","volume":"45","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B26","doi-asserted-by":"crossref","first-page":"E3403","DOI":"10.1073\/pnas.1603269113","article-title":"Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins","volume":"113","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180103185638_B27","doi-asserted-by":"crossref","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","article-title":"UniProt: the universal protein knowledgebase","volume":"45","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B28","doi-asserted-by":"crossref","first-page":"D481","DOI":"10.1093\/nar\/gkv1351","article-title":"The reactome pathway knowledgebase","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B29","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103185638_B30","doi-asserted-by":"crossref","first-page":"8.22.1","DOI":"10.1002\/cpbi.26","article-title":"Exploring short linear motifs using the ELM database and tools","volume-title":"Current Protocols in Bioinformatics","year":"2017"},{"key":"key\n\t\t\t\t20180103185638_B31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tibs.2014.11.001","article-title":"How pathogens use linear motifs to perturb host cell networks","volume":"40","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"key\n\t\t\t\t20180103185638_B32","first-page":"1","article-title":"Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey","volume":"5","year":"2014","journal-title":"Front. Microbiol."},{"key":"key\n\t\t\t\t20180103185638_B33","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.molcel.2007.11.011","article-title":"Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase","volume":"28","year":"2007","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180103185638_B34","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1126\/science.1138960","article-title":"The phosphothreonine lyase activity of a bacterial type III effector family","volume":"315","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t20180103185638_B35","doi-asserted-by":"crossref","first-page":"21743","DOI":"10.1073\/pnas.1010243107","article-title":"Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly","volume":"107","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180103185638_B36","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.str.2012.07.015","article-title":"Enterohaemorrhagic escherichia coli exploits a tryptophan switch to hijack host F-Actin assembly","volume":"20","year":"2012","journal-title":"Structure"},{"key":"key\n\t\t\t\t20180103185638_B37","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1074\/jbc.M208155200","article-title":"Attenuation of Helicobacter pylori CagA\u00b7SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase","volume":"278","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180103185638_B38","article-title":"The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase","volume":"5","year":"2014","journal-title":"Mbio"},{"key":"key\n\t\t\t\t20180103185638_B39","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1083\/jcb.201408090","article-title":"Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration","volume":"207","year":"2014","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20180103185638_B40","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.it.2005.02.002","article-title":"Src and Syk kinases: key regulators of phagocytic cell activation","volume":"26","year":"2005","journal-title":"Trends Immunol."},{"key":"key\n\t\t\t\t20180103185638_B41","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1128\/JCM.02330-08","article-title":"Polymorphism in the cagA EPIYA motif impacts development of gastric cancer","volume":"47","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"key\n\t\t\t\t20180103185638_B42","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","year":"2003","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20180103185638_B43","first-page":"ra74","article-title":"Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove","volume":"5","year":"2012","journal-title":"Sci. Signal."},{"key":"key\n\t\t\t\t20180103185638_B44","doi-asserted-by":"crossref","first-page":"837","DOI":"10.15252\/msb.20156269","article-title":"Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases","volume":"11","year":"2015","journal-title":"Mol. Syst. Biol."},{"key":"key\n\t\t\t\t20180103185638_B45","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1128\/MMBR.00043-14","article-title":"JNK Signaling : regulation and functions based on complex protein- protein partnerships","volume":"80","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"key\n\t\t\t\t20180103185638_B46","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","year":"2004","journal-title":"J. Comput. Chem."},{"key":"key\n\t\t\t\t20180103185638_B47","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrm1401","article-title":"Polo-like kinases and the orchestration of cell division","volume":"5","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20180103185638_B48","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00018-010-0279-9","article-title":"Polo-box domain: a versatile mediator of polo-like kinase function","volume":"67","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"key\n\t\t\t\t20180103185638_B49","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/sj.onc.1208280","article-title":"Structure and function of Polo-like kinases","volume":"24","year":"2005","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20180103185638_B50","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1093\/bioinformatics\/btv155","article-title":"QSLiMFinder: improved short linear motif prediction using specific query protein data","volume":"31","year":"2015","journal-title":"Bioinformatics"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/D1\/D428\/23162234\/gkx1077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T10:40:39Z","timestamp":1522665639000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/nar\/article\/46\/D1\/D428\/4612965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,10]]},"references-count":50,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2017,11,10]]},"published-print":{"date-parts":[[2018,1,4]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkx1077","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1,4]]},"published":{"date-parts":[[2017,11,10]]}}}