{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:43:39Z","timestamp":1775983419625,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,3]]},"DOI":"10.1093\/nar\/gkx289","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T07:51:57Z","timestamp":1492674717000},"page":"W64-W71","source":"Crossref","is-referenced-by-count":28,"title":["SeMPI: a genome-based secondary metabolite prediction and identification web server"],"prefix":"10.1093","volume":"45","author":[{"given":"Paul F.","family":"Zierep","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e0lia","family":"Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitar G.","family":"Yonchev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran K.","family":"Telukunta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Klementz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"key\n\t\t\t\t20170704095321_B1","doi-asserted-by":"crossref","first-page":"D509","DOI":"10.1093\/nar\/gkv1319","article-title":"StreptomeDB 2.0\u2013an extended resource of natural products produced by streptomycetes","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170704095321_B2","first-page":"186","article-title":"Advances in polyketide synthase structure and function","volume":"11","year":"2008","journal-title":"Curr. Opin. Drug Discovery Dev."},{"key":"key\n\t\t\t\t20170704095321_B3","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1039\/c2np20019h","article-title":"The structures of type I polyketide synthases","volume":"29","year":"2012","journal-title":"Nat. Prod. Rep."},{"key":"key\n\t\t\t\t20170704095321_B4","volume-title":"Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates","year":"2009","edition":"1st edn"},{"key":"key\n\t\t\t\t20170704095321_B5","doi-asserted-by":"crossref","first-page":"e1000351","DOI":"10.1371\/journal.pcbi.1000351","article-title":"Towards prediction of metabolic products of polyketide synthases: an In Silico Analysis","volume":"5","year":"2009","journal-title":"PLoS Comput. Biol."},{"key":"key\n\t\t\t\t20170704095321_B6","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1590\/S1517-83822013000400002","article-title":"Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics","volume":"44","year":"2013","journal-title":"Braz. J. Microbiol."},{"key":"key\n\t\t\t\t20170704095321_B7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00253-012-4551-9","article-title":"New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters","volume":"97","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"key\n\t\t\t\t20170704095321_B8","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1002\/cbic.201500402","article-title":"Biosynthesis of the fluorinated natural product nucleocidin in Streptomyces calvus is dependent on the bldA-Specified Leu-tRNA(UUA) molecule","volume":"16","year":"2015","journal-title":"Chembiochem"},{"key":"key\n\t\t\t\t20170704095321_B9","doi-asserted-by":"crossref","first-page":"W237","DOI":"10.1093\/nar\/gkv437","article-title":"antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters","volume":"43","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170704095321_B10","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/molbev\/mst025","article-title":"Detecting sequence homology at the gene cluster level with MultiGeneBlast","volume":"30","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"key\n\t\t\t\t20170704095321_B11","doi-asserted-by":"crossref","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","article-title":"The Pfam protein families database: towards a more sustainable future","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170704095321_B12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature13423","article-title":"Structure of a modular polyketide synthase","volume":"510","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170704095321_B13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/1471-2105-10-185","article-title":"Automated genome mining for natural products","volume":"10","year":"2009","journal-title":"BMC Bioinf."},{"key":"key\n\t\t\t\t20170704095321_B14","first-page":"9645","article-title":"Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)","volume":"43","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170704095321_B15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-62703-646-7_6","article-title":"Clustal omega, accurate alignment of very large numbers of sequences","volume":"1079","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t20170704095321_B16","doi-asserted-by":"crossref","first-page":"W30","DOI":"10.1093\/nar\/gkv397","article-title":"HMMER web server: 2015 update","volume":"43","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170704095321_B17","doi-asserted-by":"crossref","first-page":"D408","DOI":"10.1093\/nar\/gks1177","article-title":"DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters","volume":"41","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170704095321_B18","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gki487","article-title":"GeneMark: web software for gene finding in prokaryotes, eukaryotes and viruses","volume":"33","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170704095321_B19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S1074-5521(03)00156-X","article-title":"The structure of docking domains in modular polyketide synthases","volume":"10","year":"2003","journal-title":"Chem. Biol."},{"key":"key\n\t\t\t\t20170704095321_B20","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1073\/pnas.0601924103","article-title":"The 2.7-\u00c5 crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase","volume":"103","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170704095321_B21","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1039\/b103920m","article-title":"Modification of post-PKS tailoring steps through combinatorial biosynthesis","volume":"19","year":"2002","journal-title":"Nat. Prod. Rep."},{"key":"key\n\t\t\t\t20170704095321_B22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1039\/b911956f","article-title":"Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis","volume":"27","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"key\n\t\t\t\t20170704095321_B23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nchembio.1890","article-title":"Minimum information about a biosynthetic gene cluster","volume":"11","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"key\n\t\t\t\t20170704095321_B24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0167-5877(00)00115-X","article-title":"Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests","volume":"45","year":"2000","journal-title":"Prev. Vet. Med."},{"key":"key\n\t\t\t\t20170704095321_B25","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1039\/c2sc20410j","article-title":"Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145","volume":"3","year":"2012","journal-title":"Chem. Sci."},{"key":"key\n\t\t\t\t20170704095321_B26","doi-asserted-by":"crossref","first-page":"28607","DOI":"10.1074\/jbc.M804279200","article-title":"Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis","volume":"283","year":"2008","journal-title":"J. Biol. Chem."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/45\/W1\/W64\/18137240\/gkx289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T14:40:56Z","timestamp":1522680056000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkx289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,27]]},"references-count":26,"journal-issue":{"issue":"W1","published-online":{"date-parts":[[2017,4,27]]},"published-print":{"date-parts":[[2017,7,3]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkx289","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,27]]}}}