{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:48:13Z","timestamp":1791607693191,"version":"4.3.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,4]]},"DOI":"10.1093\/nar\/gkx925","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T19:11:48Z","timestamp":1507057908000},"page":"D586-D594","source":"Crossref","is-referenced-by-count":63,"title":["The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis"],"prefix":"10.1093","volume":"46","author":[{"given":"Karel","family":"Miettinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"I\u00f1igo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Kreft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Pollier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"De\u00a0Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Botzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Coppens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Bak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"key\n\t\t\t\t20180103190741_B1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/10409238.2014.953628","article-title":"Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives","volume":"49","year":"2014","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"key\n\t\t\t\t20180103190741_B2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev-arplant-050312-120229","article-title":"Triterpene biosynthesis in plants","volume":"65","year":"2014","journal-title":"Annu. Rev. Plant Biol."},{"key":"key\n\t\t\t\t20180103190741_B3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1469-8137.2006.01863.x","article-title":"First encounters \u2013 deployment of defence\u2010related natural products by plants","volume":"172","year":"2006","journal-title":"New Phytol."},{"key":"key\n\t\t\t\t20180103190741_B4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/jxb\/erq366","article-title":"Composition differences between epicuticular and intracuticular wax substructures: how do plants seal their epidermal surfaces","volume":"62","year":"2011","journal-title":"J. Exp. Bot."},{"key":"key\n\t\t\t\t20180103190741_B5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.phytochem.2006.10.008","article-title":"Saponins, classification and occurrence in the plant kingdom","volume":"68","year":"2007","journal-title":"Phytochemistry"},{"key":"key\n\t\t\t\t20180103190741_B6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fmed.2017.00069","article-title":"Celastrol: a spectrum of treatment opportunities in chronic diseases","volume":"4","year":"2017","journal-title":"Front. Med."},{"key":"key\n\t\t\t\t20180103190741_B7","first-page":"e113","article-title":"QS-21: a potent vaccine adjuvant","volume":"3","year":"2016","journal-title":"Nat Prod. Chem. Res."},{"key":"key\n\t\t\t\t20180103190741_B8","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1351\/pac200274071189","article-title":"Licorice root. A natural sweetener and an important ingredient in Chinese medicine","volume":"74","year":"2002","journal-title":"Pure Appl. Chem."},{"key":"key\n\t\t\t\t20180103190741_B9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/10408390600698197","article-title":"Saponins: properties, applications and processing","volume":"47","year":"2007","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"key\n\t\t\t\t20180103190741_B10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/BF02866642","article-title":"Industrial uses and sustainable supply of Quillaja saponaria (Rosaceae) saponins","volume":"53","year":"1999","journal-title":"Econ. Bot."},{"key":"key\n\t\t\t\t20180103190741_B11","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/mnfr.201100722","article-title":"Effects of plant sterols and stanols on intestinal cholesterol metabolism: suggested mechanisms from past to present","volume":"56","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"key\n\t\t\t\t20180103190741_B12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1146\/annurev-arplant-050312-120116","article-title":"Network analysis of the MVA and MEP pathways for isoprenoid synthesis","volume":"64","year":"2013","journal-title":"Annu. Rev. Plant Biol."},{"key":"key\n\t\t\t\t20180103190741_B13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.phytochem.2011.01.015","article-title":"Molecular activities, biosynthesis and evolution of triterpenoid saponins","volume":"72","year":"2011","journal-title":"Phytochemistry"},{"key":"key\n\t\t\t\t20180103190741_B14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1039\/c3np70104b","article-title":"Natural product biosynthesis in Medicago species","volume":"31","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"key\n\t\t\t\t20180103190741_B15","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1039\/b616857b","article-title":"Enzymatic synthesis of cyclic triterpenes","volume":"24","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"key\n\t\t\t\t20180103190741_B16","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/cbic.200900672","article-title":"Molecular evolution of fern squalene cyclases","volume":"11","year":"2010","journal-title":"ChemBioChem"},{"key":"key\n\t\t\t\t20180103190741_B17","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1073\/pnas.1323369111","article-title":"Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16\u03b1 hydroxylase from Bupleurum falcatum","volume":"111","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180103190741_B18","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/pcp\/pcv062","article-title":"P450s and UGTs: key players in the structural diversity of triterpenoid saponins","volume":"56","year":"2015","journal-title":"Plant Cell Physiol."},{"key":"key\n\t\t\t\t20180103190741_B19","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1021\/cr200021m","article-title":"Biosynthesis of cholesterol and other sterols","volume":"111","year":"2011","journal-title":"Chem. Rev."},{"key":"key\n\t\t\t\t20180103190741_B20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0163-7827(02)00047-4","article-title":"The role of sterols in plant growth and development","volume":"42","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"key\n\t\t\t\t20180103190741_B21","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<939::AID-JSFA644>3.0.CO;2-C","article-title":"Plant sterols: biosynthesis, biological function and their importance to human nutrition","volume":"80","year":"2000","journal-title":"J. Sci. Food Agric."},{"key":"key\n\t\t\t\t20180103190741_B22","doi-asserted-by":"crossref","first-page":"16205","DOI":"10.1038\/nplants.2016.205","article-title":"Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism","volume":"3","year":"2016","journal-title":"Nat. Plants"},{"key":"key\n\t\t\t\t20180103190741_B23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.1240230","article-title":"Biosynthesis of antinutritional alkaloids in solanaceous crops is mediated by clustered genes","volume":"341","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20180103190741_B24","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/nph.13269","article-title":"The molecular circuitry of brassinosteroid signaling","volume":"206","year":"2015","journal-title":"New Phytol."},{"key":"key\n\t\t\t\t20180103190741_B25","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/mp\/ssu050","article-title":"Connecting growth and defense: the emerging roles of brassinosteroids and gibberellins in plant innate immunity","volume":"7","year":"2014","journal-title":"Mol. Plant"},{"key":"key\n\t\t\t\t20180103190741_B26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tplants.2014.09.003","article-title":"Trade-off between growth and immunity: role of brassinosteroids","volume":"20","year":"2015","journal-title":"Trends Plant Sci."},{"key":"key\n\t\t\t\t20180103190741_B27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.arplant.54.031902.134921","article-title":"Biosynthesis and metabolism of brassinosteroids","volume":"54","year":"2003","journal-title":"Annu. Rev. Plant Biol."},{"key":"key\n\t\t\t\t20180103190741_B28","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/mp\/sst096","article-title":"From squalene to brassinolide: the steroid metabolic and signaling pathways across the plant kingdom","volume":"6","year":"2013","journal-title":"Mol. Plant Breed."},{"key":"key\n\t\t\t\t20180103190741_B29","doi-asserted-by":"crossref","first-page":"E81","DOI":"10.1073\/pnas.1419547112","article-title":"Investigation of terpene diversification across multiple sequenced plant genomes","volume":"112","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180103190741_B30","doi-asserted-by":"crossref","first-page":"E7619","DOI":"10.1073\/pnas.1604828113","article-title":"The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii","volume":"113","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180103190741_B31","doi-asserted-by":"crossref","first-page":"16183","DOI":"10.1038\/nplants.2016.183","article-title":"Convergence and divergence of bitterness biosynthesis and regulation in Cucurbitaceae","volume":"2","year":"2016","journal-title":"Nat. Plants"},{"key":"key\n\t\t\t\t20180103190741_B32","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1105\/tpc.114.134486","article-title":"OSC2 and CYP716A14v2 catalyze the biosynthesis of triterpenoids for the cuticle of aerial organs of Artemisia annua","volume":"27","year":"2015","journal-title":"Plant Cell"},{"key":"key\n\t\t\t\t20180103190741_B33","doi-asserted-by":"crossref","first-page":"14153","DOI":"10.1038\/ncomms14153","article-title":"The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis","volume":"8","year":"2017","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20180103190741_B34","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1038\/srep03698","article-title":"Producing aglycons of ginsenosides in bakers' yeast","volume":"4","year":"2014","journal-title":"Sci. Rep."},{"key":"key\n\t\t\t\t20180103190741_B35","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1104\/pp.15.01548","article-title":"Engineering triterpene and methylated triterpene production in plants provides biochemical and physiological insights into terpene metabolism","volume":"170","year":"2016","journal-title":"Plant Physiol."},{"key":"key\n\t\t\t\t20180103190741_B36","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/bit.25573","article-title":"Triterpene hydrocarbon production engineered into a metabolically versatile host\u2014Rhodobacter capsulatus","volume":"112","year":"2015","journal-title":"Biotechnol. Bioeng."},{"key":"key\n\t\t\t\t20180103190741_B37","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1111\/j.1742-4658.2008.06343.x","article-title":"Engineering triterpene production in Saccharomyces cerevisiae \u2013 \u03b2-amyrin synthase from Artemisia annua","volume":"275","year":"2008","journal-title":"FEBS J."},{"key":"key\n\t\t\t\t20180103190741_B38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ymben.2017.06.012","article-title":"A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules","volume":"42","year":"2017","journal-title":"Metab. Eng."},{"key":"key\n\t\t\t\t20180103190741_B39","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/bit.25588","article-title":"Building terpene production platforms in yeast","volume":"112","year":"2015","journal-title":"Biotechnol. Bioeng."},{"key":"key\n\t\t\t\t20180103190741_B40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1574-1400(08)00012-1","article-title":"PubChem: integrated platform of small molecules and biological activities","volume":"4","year":"2008","journal-title":"Annu. Rep. Comput. Chem."},{"key":"key\n\t\t\t\t20180103190741_B41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/ci00057a005","article-title":"SMILES, a chemical language and information system. 1. Introduction to methodology and encoding rules","volume":"28","year":"1988","journal-title":"J. Chem Inf. Model."},{"key":"key\n\t\t\t\t20180103190741_B42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13321-015-0061-y","article-title":"Wikipedia Chemical Structure Explorer: substructure and similarity searching of molecules from Wikipedia","volume":"7","year":"2015","journal-title":"J. Cheminformatics"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/D1\/D586\/23162744\/gkx925.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T18:31:45Z","timestamp":1693074705000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/nar\/article\/46\/D1\/D586\/4555231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,17]]},"references-count":42,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2017,10,17]]},"published-print":{"date-parts":[[2018,1,4]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkx925","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1,4]]},"published":{"date-parts":[[2017,10,17]]}}}