{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:55:12Z","timestamp":1776786912263,"version":"3.51.2"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,4]]},"DOI":"10.1093\/nar\/gkx997","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T11:09:17Z","timestamp":1508411357000},"page":"D213-D217","source":"Crossref","is-referenced-by-count":151,"title":["APPRIS 2017: principal isoforms for multiple gene sets"],"prefix":"10.1093","volume":"46","author":[{"given":"Jose Manuel","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Rodriguez-Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s","family":"Di\u00a0Domenico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L","family":"Tress","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"key\n\t\t\t\t20180103190627_B1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing","volume":"40","year":"2008","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180103190627_B2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07509","article-title":"Alternative isoform regulation in human tissue transcriptomes","volume":"456","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180103190627_B3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0968-0004(00)01604-2","article-title":"Alternative pre-mRNA splicing: the logic of combinatorial control","volume":"25","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"key\n\t\t\t\t20180103190627_B4","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1073\/pnas.0700800104","article-title":"The implications of alternative splicing in the ENCODE protein complement","volume":"104","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180103190627_B5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.tibs.2016.08.008","article-title":"Alternative splicing may not be the key to proteome complexity","volume":"42","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"key\n\t\t\t\t20180103190627_B6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.tibs.2017.04.001","article-title":"The relationship between alternative splicing and proteomic complexity","volume":"42","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"key\n\t\t\t\t20180103190627_B7","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.tibs.2017.04.002","article-title":"Most alternative isoforms are not functionally important","volume":"42","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"key\n\t\t\t\t20180103190627_B8","doi-asserted-by":"crossref","first-page":"D110","DOI":"10.1093\/nar\/gks1058","article-title":"APPRIS: annotation of principal and alternative splice isoforms","volume":"41","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B9","doi-asserted-by":"crossref","first-page":"W455","DOI":"10.1093\/nar\/gkv512","article-title":"APPRIS WebServer and WebServices","volume":"43","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B10","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: the reference human genome annotation for The ENCODE Project","volume":"22","year":"2012","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20180103190627_B11","doi-asserted-by":"crossref","first-page":"D305","DOI":"10.1093\/nar\/gkn869","article-title":"AS-ALPS: a database for analyzing the effects of alternative splicing on protein structure, interaction and network in human and mouse","volume":"37","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B12","doi-asserted-by":"crossref","first-page":"D80","DOI":"10.1093\/nar\/gkq1073","article-title":"ASPicDB: a database of annotated transcript and protein variants generated by alternative splicing","volume":"39","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B13","doi-asserted-by":"crossref","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","article-title":"The Pfam protein families database: towards a more sustainable future","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B14","doi-asserted-by":"crossref","first-page":"W235","DOI":"10.1093\/nar\/gkr437","article-title":"firestar\u2013advances in the prediction of functionally important residues","volume":"39","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/bioinformatics\/btm547","article-title":"Determination and validation of principal gene products","volume":"24","year":"2008","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180103190627_B16","doi-asserted-by":"crossref","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","article-title":"UniProt: the universal protein knowledgebase","volume":"45","author":"The UniProt Consortium","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B17","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1021\/pr501286b","article-title":"Most highly expressed protein-coding genes have a single dominant isoform","volume":"14","year":"2015","journal-title":"J. Proteome Res."},{"key":"key\n\t\t\t\t20180103190627_B18","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1021\/acs.jproteome.5b00494","article-title":"Functional networks of highest-connected splice isoforms: From the chromosome 17 human proteome project","volume":"14","year":"2015","journal-title":"J. Proteome Res."},{"key":"key\n\t\t\t\t20180103190627_B19","doi-asserted-by":"crossref","first-page":"baw093","DOI":"10.1093\/database\/baw093","article-title":"The Ensembl gene annotation system","volume":"2016","year":"2016","journal-title":"Database (Oxford)"},{"key":"key\n\t\t\t\t20180103190627_B20","doi-asserted-by":"crossref","first-page":"D733","DOI":"10.1093\/nar\/gkv1189","article-title":"Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B21","first-page":"D271","article-title":"The RCSB protein data bank: integrative view of protein, gene and 3D structural information","volume":"45","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B22","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B23","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/bioinformatics\/btl677","article-title":"Improving the accuracy of transmembrane protein topology prediction using evolutionary information","volume":"23","year":"2007","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180103190627_B24","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jmb.2004.03.016","article-title":"A combined transmembrane topology and signal peptide prediction method","volume":"338","year":"2004","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20180103190627_B25","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1110\/ps.04625404","article-title":"Best alpha-helical transmembrane protein topology predictions are achieved using hidden Markov models and evolutionary information","volume":"13","year":"2004","journal-title":"Protein Sci."},{"key":"key\n\t\t\t\t20180103190627_B26","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","year":"2011","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20180103190627_B27","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1006\/jmbi.2000.3903","article-title":"Predicting subcellular localization of proteins based on their N-terminal amino acid sequence","volume":"300","year":"2000","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20180103190627_B28","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1101\/gr.080531.108","article-title":"The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes","volume":"19","year":"2009","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20180103190627_B29","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1093\/hmg\/ddu309","article-title":"Multiple evidence strands suggest that there may be as few as 19, 000 human protein-coding genes","volume":"23","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20180103190627_B30","first-page":"D626","article-title":"The UCSC Genome Browser database: 2017 update","volume":"45","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B31","doi-asserted-by":"crossref","first-page":"W589","DOI":"10.1093\/nar\/gkv350","article-title":"The BioMart community portal: an innovative alternative to large, centralized data repositories","volume":"43","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180103190627_B32","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1039\/C5MB00132C","article-title":"The distribution pattern of genetic variation in the transcript isoforms of the alternatively spliced protein-coding genes in the human genome","volume":"11","year":"2015","journal-title":"Mol. Biosyst."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/D1\/D213\/23162962\/gkx997.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T14:41:26Z","timestamp":1522680086000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/nar\/article\/46\/D1\/D213\/4561658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":32,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2017,10,23]]},"published-print":{"date-parts":[[2018,1,4]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkx997","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1,4]]},"published":{"date-parts":[[2017,10,23]]}}}