{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:10:29Z","timestamp":1775560229284,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473236"],"award-info":[{"award-number":["81473236"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Project on Precision Medicine under the National Key R&D Program","award":["2016YFC0903000"],"award-info":[{"award-number":["2016YFC0903000"]}]},{"name":"Fundamental Research Funds for Central Universities of China","award":["BMU2017YJ004"],"award-info":[{"award-number":["BMU2017YJ004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,8]]},"DOI":"10.1093\/nar\/gky1023","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T12:31:50Z","timestamp":1539779510000},"page":"D253-D258","source":"Crossref","is-referenced-by-count":310,"title":["TransmiR v2.0: an updated transcription factor-microRNA regulation database"],"prefix":"10.1093","volume":"47","author":[{"given":"Zhan","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China"}]},{"given":"Qinghua","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China"}]}],"member":"286","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"key\n\t\t\t\t2019010800381969000_B1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019010800381969000_B2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t2019010800381969000_B3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrm2868","article-title":"MicroRNA control of signal transduction","volume":"11","author":"Inui","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t2019010800381969000_B4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"key\n\t\t\t\t2019010800381969000_B5","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/CIRCRESAHA.107.163147","article-title":"Emerging role of microRNAs in cardiovascular biology","volume":"101","author":"Latronico","year":"2007","journal-title":"Circ. Res."},{"key":"key\n\t\t\t\t2019010800381969000_B6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/CIRCRESAHA.111.247452","article-title":"Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease","volume":"110","author":"Creemers","year":"2012","journal-title":"Circ. Res."},{"key":"key\n\t\t\t\t2019010800381969000_B7","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/nn.4373","article-title":"Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder","volume":"19","author":"Wu","year":"2016","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t2019010800381969000_B8","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/aur.1789","article-title":"MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research","volume":"10","author":"Hu","year":"2017","journal-title":"Autism Res."},{"key":"key\n\t\t\t\t2019010800381969000_B9","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/bioinformatics\/btt423","article-title":"Identification of active transcription factor and miRNA regulatory pathways in Alzheimer's disease","volume":"29","author":"Jiang","year":"2013","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t2019010800381969000_B10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cels.2016.06.006","article-title":"Causal mechanistic regulatory network for glioblastoma deciphered using systems genetics network analysis","volume":"3","author":"Plaisier","year":"2016","journal-title":"Cell Syst."},{"key":"key\n\t\t\t\t2019010800381969000_B11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/bioinformatics\/btu597","article-title":"Gene regulatory networks by transcription factors and microRNAs in breast cancer","volume":"31","author":"Qin","year":"2015","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t2019010800381969000_B12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/bib\/bbt085","article-title":"Transcription factor and microRNA co-regulatory loops: important regulatory motifs in biological processes and diseases","volume":"16","author":"Zhang","year":"2015","journal-title":"Brief. Bioinformatics"},{"key":"key\n\t\t\t\t2019010800381969000_B13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019010800381969000_B14","doi-asserted-by":"crossref","first-page":"i746","DOI":"10.1093\/bioinformatics\/btw452","article-title":"Genome wide predictions of miRNA regulation by transcription factors","volume":"32","author":"Ruffalo","year":"2016","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t2019010800381969000_B15","doi-asserted-by":"crossref","first-page":"D43","DOI":"10.1093\/nar\/gkw965","article-title":"ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data","volume":"45","author":"Zhou","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B16","doi-asserted-by":"crossref","first-page":"D168","DOI":"10.1093\/nar\/gkx996","article-title":"mirTrans: a resource of transcriptional regulation on microRNAs for human cell lines","volume":"46","author":"Hua","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B17","doi-asserted-by":"crossref","first-page":"D190","DOI":"10.1093\/nar\/gkv1254","article-title":"DIANA-miRGen v3.0: accurate characterization of microRNA promoters and their regulators","volume":"44","author":"Georgakilas","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B18","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1038\/srep05150","article-title":"Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues","volume":"4","author":"Guo","year":"2014","journal-title":"Sci. Rep."},{"key":"key\n\t\t\t\t2019010800381969000_B19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1186\/1471-2105-11-435","article-title":"CircuitsDB: a database of mixed microRNA\/transcription factor feed-forward regulatory circuits in human and mouse","volume":"11","author":"Friard","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t2019010800381969000_B20","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature13182","article-title":"A promoter-level mammalian expression atlas","volume":"507","author":"Forrest","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019010800381969000_B21","doi-asserted-by":"crossref","first-page":"D119","DOI":"10.1093\/nar\/gkp803","article-title":"TransmiR: a transcription factor-microRNA regulation database","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B22","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pinero","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B23","doi-asserted-by":"crossref","first-page":"eaan2507","DOI":"10.1126\/science.aan2507","article-title":"A pathology atlas of the human cancer transcriptome","volume":"357","author":"Uhlen","year":"2017","journal-title":"Science"},{"key":"key\n\t\t\t\t2019010800381969000_B24","doi-asserted-by":"crossref","first-page":"D477","DOI":"10.1093\/nar\/gkx1019","article-title":"The OMA orthology database in 2018: retrieving evolutionary relationships among all domains of life through richer web and programmatic interfaces","volume":"46","author":"Altenhoff","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B25","doi-asserted-by":"crossref","first-page":"D1070","DOI":"10.1093\/nar\/gkt1023","article-title":"HMDD v2.0: a database for experimentally supported human microRNA and disease associations","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B26","doi-asserted-by":"crossref","first-page":"D153","DOI":"10.1093\/nar\/gku1215","article-title":"DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B27","doi-asserted-by":"crossref","first-page":"D296","DOI":"10.1093\/nar\/gkx1067","article-title":"miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions","volume":"46","author":"Chou","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B28","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"miRBase: annotating high confidence microRNAs using deep sequencing data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B29","doi-asserted-by":"crossref","first-page":"D762","DOI":"10.1093\/nar\/gkx1020","article-title":"The UCSC Genome Browser database: 2018 update","volume":"46","author":"Casper","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t2019010800381969000_B31","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nbt.3947","article-title":"An integrated expression atlas of miRNAs and their promoters in human and mouse","volume":"35","author":"de\u00a0Rie","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t2019010800381969000_B32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s40484-017-0123-4","article-title":"Cap-seq reveals complicated miRNA transcriptional mechanisms in C. elegans and mouse","volume":"5","author":"Chen","year":"2017","journal-title":"Quant. Biol."},{"key":"key\n\t\t\t\t2019010800381969000_B33","doi-asserted-by":"crossref","first-page":"R40","DOI":"10.1186\/gb-2009-10-4-r40","article-title":"The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation","volume":"10","author":"Kawaji","year":"2009","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t2019010800381969000_B34","doi-asserted-by":"crossref","first-page":"D61","DOI":"10.1093\/nar\/gkw951","article-title":"GTRD: a database of transcription factor binding sites identified by ChIP-seq experiments","volume":"45","author":"Yevshin","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B35","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t2019010800381969000_B36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1672-0229(09)60001-2","article-title":"Identification of conserved regulatory elements in mammalian promoter regions: a case study using the PCK1 promoter","volume":"6","author":"Liu","year":"2008","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"key\n\t\t\t\t2019010800381969000_B37","doi-asserted-by":"crossref","first-page":"W180","DOI":"10.1093\/nar\/gky509","article-title":"TAM 2.0: tool for MicroRNA set analysis","volume":"46","author":"Li","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800381969000_B38","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1210\/endo.140.3.6595","article-title":"In vivo insulin signaling in the myocardium of streptozotocin-diabetic rats: opposite effects of diabetes on insulin stimulation of glycogen synthase and c-Fos","volume":"140","author":"Wang","year":"1999","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019010800381969000_B39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13098-017-0205-5","article-title":"Interaction between peroxisome proliferator-activated receptor gamma polymorphism and obesity on type 2 diabetes in a Chinese Han population","volume":"9","author":"Lv","year":"2017","journal-title":"Diabetol. Metab. Syndrome"},{"key":"key\n\t\t\t\t2019010800381969000_B40","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.2337\/dc16-2462","article-title":"Diabetes, associated clinical spectrum, Long-term prognosis, and Genotype\/Phenotype correlations in 201 adult patients with hepatocyte nuclear factor 1B (HNF1B) molecular defects","volume":"40","author":"Dubois-Laforgue","year":"2017","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019010800381969000_B41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gene.2016.01.039","article-title":"Role of microRNA 21 in diabetes and associated\/related diseases","volume":"582","author":"Sekar","year":"2016","journal-title":"Gene"},{"key":"key\n\t\t\t\t2019010800381969000_B42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1210\/endo.134.1.8275944","article-title":"Regulation of c-fos expression in adipose and muscle tissue of diabetic rats","volume":"134","author":"Olson","year":"1994","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019010800381969000_B43","doi-asserted-by":"crossref","first-page":"13127","DOI":"10.1073\/pnas.1410428111","article-title":"Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes","volume":"111","author":"Majithia","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t2019010800381969000_B44","doi-asserted-by":"crossref","first-page":"L371","DOI":"10.1152\/ajplung.00532.2016","article-title":"Peroxisome proliferator-activated receptor-gamma enhances human pulmonary artery smooth muscle cell apoptosis through microRNA-21 and programmed cell death 4","volume":"313","author":"Green","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"key\n\t\t\t\t2019010800381969000_B45","doi-asserted-by":"crossref","first-page":"25093","DOI":"10.18632\/oncotarget.4437","article-title":"Hepatocellular carcinoma associated microRNA expression signature: integrated bioinformatics analysis, experimental validation and clinical significance","volume":"6","author":"Shi","year":"2015","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t2019010800381969000_B46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/CJI.0000000000000166","article-title":"Transforming growth factor beta is a poor prognostic factor and inhibits the favorable prognostic value of CD8+ CTL in human hepatocellular carcinoma","volume":"40","author":"Huang","year":"2017","journal-title":"J. Immunother."},{"key":"key\n\t\t\t\t2019010800381969000_B47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12943-015-0431-0","article-title":"Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2","volume":"14","author":"Huang","year":"2015","journal-title":"Mol. Cancer"},{"key":"key\n\t\t\t\t2019010800381969000_B48","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/emmm.201202406","article-title":"Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence","volume":"5","author":"Hampl","year":"2013","journal-title":"EMBO Mol. Med."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/47\/D1\/D253\/27436106\/gky1023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T07:46:42Z","timestamp":1605253602000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/47\/D1\/D253\/5146188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,29]]},"references-count":48,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2018,10,29]]},"published-print":{"date-parts":[[2019,1,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky1023","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1,8]]},"published":{"date-parts":[[2018,10,29]]}}}