{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:15:48Z","timestamp":1774005348571,"version":"3.50.1"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T00:00:00Z","timestamp":1541808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,8]]},"DOI":"10.1093\/nar\/gky1074","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T11:09:39Z","timestamp":1539947379000},"page":"D298-D308","source":"Crossref","is-referenced-by-count":212,"title":["dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications"],"prefix":"10.1093","volume":"47","author":[{"given":"Kai-Yao","family":"Huang","sequence":"first","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Life and Health Science, The Chinese University of Hong Kong, Shenzhen 518172, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-7868","authenticated-orcid":false,"given":"Tzong-Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Life and Health Science, The Chinese University of Hong Kong, Shenzhen 518172, China"}]},{"given":"Hui-Ju","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Yuan Ze University, Taoyuan 32003, Taiwan"}]},{"given":"Chen-Tse","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Yuan Ze University, Taoyuan 32003, Taiwan"}]},{"given":"Chao-Chun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Yuan Ze University, Taoyuan 32003, Taiwan"}]},{"given":"Tsai-Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Yuan Ze University, Taoyuan 32003, Taiwan"}]},{"given":"Wen-Chi","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Tropical Plant Sciences, College of Biosciences and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan"}]},{"given":"Hsien-Da","family":"Huang","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Life and Health Science, The Chinese University of Hong Kong, Shenzhen 518172, China"}]}],"member":"286","published-online":{"date-parts":[[2018,11,10]]},"reference":[{"key":"key\n\t\t\t\t2019010803585727900_B1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nature05757","article-title":"Expanding the diversity of chemical protein modification allows post-translational mimicry","volume":"446","author":"van\u00a0Kasteren","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019010803585727900_B2","doi-asserted-by":"crossref","first-page":"D622","DOI":"10.1093\/nar\/gkj083","article-title":"dbPTM: an information repository of protein post-translational modification","volume":"34","author":"Lee","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B3","doi-asserted-by":"crossref","first-page":"D777","DOI":"10.1093\/nar\/gkq970","article-title":"RegPhos: a system to explore the protein kinase-substrate phosphorylation network in humans","volume":"39","author":"Lee","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrm1960","article-title":"Reading protein modifications with interaction domains","volume":"7","author":"Seet","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t2019010803585727900_B5","doi-asserted-by":"crossref","first-page":"bau034","DOI":"10.1093\/database\/bau034","article-title":"RegPhos 2.0: an updated resource to explore protein kinase-substrate phosphorylation networks in mammals","volume":"2014","author":"Huang","year":"2014","journal-title":"Database"},{"key":"key\n\t\t\t\t2019010803585727900_B6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41588-017-0001-z","article-title":"Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence","volume":"50","author":"Turcan","year":"2018","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2019010803585727900_B7","doi-asserted-by":"crossref","first-page":"528650","DOI":"10.1155\/2014\/528650","article-title":"An intelligent system for identifying acetylated lysine on histones and nonhistone proteins","volume":"2014","author":"Lu","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"key\n\t\t\t\t2019010803585727900_B8","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1074\/mcp.R114.046664","article-title":"Metabolic regulation by Lysine Malonylation, Succinylation, and Glutarylation","volume":"14","author":"Hirschey","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"key\n\t\t\t\t2019010803585727900_B9","doi-asserted-by":"crossref","first-page":"baw054","DOI":"10.1093\/database\/baw054","article-title":"UbiNet: an online resource for exploring the functional associations and regulatory networks of protein ubiquitylation","volume":"2016","author":"Nguyen","year":"2016","journal-title":"Database"},{"key":"key\n\t\t\t\t2019010803585727900_B10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nbt0303-255","article-title":"Proteomic analysis of post-translational modifications","volume":"21","author":"Mann","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t2019010803585727900_B11","first-page":"35","article-title":"Post-translational modifications and their biological functions: proteomic analysis and systematic approaches","volume":"37","author":"Seo","year":"2004","journal-title":"J. Biochem. Mol. Biol."},{"key":"key\n\t\t\t\t2019010803585727900_B12","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1074\/mcp.M900487-MCP200","article-title":"A novel approach for untargeted post-translational modification identification using integer linear optimization and tandem mass spectrometry","volume":"9","author":"Baliban","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"key\n\t\t\t\t2019010803585727900_B13","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/pmic.200300764","article-title":"Annotation of post-translational modifications in the Swiss-Prot knowledge base","volume":"4","author":"Farriol-Mathis","year":"2004","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t2019010803585727900_B14","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1074\/mcp.M900030-MCP200","article-title":"SysPTM: a systematic resource for proteomic research on post-translational modifications","volume":"8","author":"Li","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"key\n\t\t\t\t2019010803585727900_B15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1039\/C1MB05340J","article-title":"Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis","volume":"8","author":"Goel","year":"2012","journal-title":"Mol. Biosyst."},{"key":"key\n\t\t\t\t2019010803585727900_B16","doi-asserted-by":"crossref","first-page":"D537","DOI":"10.1093\/nar\/gkt1221","article-title":"topPTM: a new module of dbPTM for identifying functional post-translational modifications in transmembrane proteins","volume":"42","author":"Su","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B17","doi-asserted-by":"crossref","first-page":"D531","DOI":"10.1093\/nar\/gkt1093","article-title":"CPLM: a database of protein lysine modifications","volume":"42","author":"Liu","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B18","doi-asserted-by":"crossref","first-page":"D435","DOI":"10.1093\/nar\/gkv1240","article-title":"dbPTM 2016: 10-year anniversary of a resource for post-translational modification of proteins","volume":"44","author":"Huang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B19","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1002\/anie.201407234","article-title":"Reactive oxygen species-responsive protein modification and its intracellular delivery for targeted cancer therapy","volume":"53","author":"Wang","year":"2014","journal-title":"Angew. Chem."},{"key":"key\n\t\t\t\t2019010803585727900_B20","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1158\/0008-5472.CAN-05-4251","article-title":"Chromatin modification of the trefoil factor 1 gene in human breast cancer cells by the Ras\/mitogen-activated protein kinase pathway","volume":"66","author":"Espino","year":"2006","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t2019010803585727900_B21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.canlet.2012.03.009","article-title":"Protein S-nitrosylation and cancer","volume":"320","author":"Wang","year":"2012","journal-title":"Cancer Lett."},{"key":"key\n\t\t\t\t2019010803585727900_B22","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1021\/pr5002675","article-title":"Decoding the s-nitrosoproteomic atlas in individualized human colorectal cancer tissues using a label-free quantitation strategy","volume":"13","author":"Chen","year":"2014","journal-title":"J. Proteome Res."},{"key":"key\n\t\t\t\t2019010803585727900_B23","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1007\/s12010-013-0443-4","article-title":"Parkin induces upregulation of 40S ribosomal protein SA and posttranslational modification of cytokeratins 8 and 18 in human cervical cancer cells","volume":"171","author":"Song","year":"2013","journal-title":"Appl. Biochem. Biotechnol."},{"key":"key\n\t\t\t\t2019010803585727900_B24","doi-asserted-by":"crossref","first-page":"34777","DOI":"10.1074\/jbc.M109.026351","article-title":"O-GlcNAc protein modification in cancer cells increases in response to glucose deprivation through glycogen degradation","volume":"284","author":"Kang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t2019010803585727900_B25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.sbi.2017.10.013","article-title":"Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications","volume":"48","author":"Csizmok","year":"2018","journal-title":"Curr. Opin. Struct. Biol."},{"key":"key\n\t\t\t\t2019010803585727900_B26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/pmic.201300344","article-title":"The next level of complexity: crosstalk of posttranslational modifications","volume":"14","author":"Venne","year":"2014","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t2019010803585727900_B27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1095\/biolreprod.116.142281","article-title":"Functional roles of Fructose: Crosstalk between O-Linked glycosylation and phosphorylation of Akt-TSC2-MTOR cell signaling cascade in ovine trophectoderm cells","volume":"95","author":"Wang","year":"2016","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t2019010803585727900_B28","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/emboj.2009.83","article-title":"Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding","volume":"28","author":"Wu","year":"2009","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t2019010803585727900_B29","doi-asserted-by":"crossref","first-page":"D827","DOI":"10.1093\/nar\/gkw1096","article-title":"dbSAP: single amino-acid polymorphism database for protein variation detection","volume":"45","author":"Cao","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B30","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/humu.20021","article-title":"The Swiss-Prot variant page and the ModSNP database: a resource for sequence and structure information on human protein variants","volume":"23","author":"Yip","year":"2004","journal-title":"Hum. Mutat."},{"issue":"Suppl. 2","key":"key\n\t\t\t\t2019010803585727900_B31","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1755-8794-8-S2-S7","article-title":"Detection and analysis of disease-associated single nucleotide polymorphism influencing post-translational modification","volume":"8","author":"Kim","year":"2015","journal-title":"BMC Med. Genomics"},{"key":"key\n\t\t\t\t2019010803585727900_B32","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1164\/rccm.201610-2006OC","article-title":"Application of a natural language processing algorithm to asthma ascertainment. An automated chart review","volume":"196","author":"Wi","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"Suppl. 1","key":"key\n\t\t\t\t2019010803585727900_B33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12918-015-0246-z","article-title":"UbiSite: incorporating two-layered machine learning method with substrate motifs to predict ubiquitin-conjugation site on lysines","volume":"10","author":"Huang","year":"2016","journal-title":"BMC Syst. Biol."},{"key":"key\n\t\t\t\t2019010803585727900_B34","doi-asserted-by":"crossref","first-page":"e85744","DOI":"10.1371\/journal.pone.0085744","article-title":"mUbiSiDa: a comprehensive database for protein ubiquitination sites in mammals","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019010803585727900_B35","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1186\/1471-2105-11-536","article-title":"Incorporating significant amino acid pairs to identify O-linked glycosylation sites on transmembrane proteins and non-transmembrane proteins","volume":"11","author":"Chen","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t2019010803585727900_B36","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/jcc.21232","article-title":"Incorporating structural characteristics for identification of protein methylation sites","volume":"30","author":"Shien","year":"2009","journal-title":"J. Comput. Chem."},{"key":"key\n\t\t\t\t2019010803585727900_B37","doi-asserted-by":"crossref","first-page":"D695","DOI":"10.1093\/nar\/gkm902","article-title":"NetworKIN: a resource for exploring cellular phosphorylation networks","volume":"36","author":"Linding","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B38","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.014076","article-title":"E3Net: a system for exploring E3-mediated regulatory networks of cellular functions","volume":"11","author":"Han","year":"2012","journal-title":"Mol.Cell. Proteomics"},{"key":"key\n\t\t\t\t2019010803585727900_B39","first-page":"653","article-title":"The construction of a database for ubiquitin signaling cascade","volume":"14","author":"Sakiyama","year":"2003","journal-title":"Genome Inform."},{"key":"key\n\t\t\t\t2019010803585727900_B40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/bioinformatics\/btx541","article-title":"tmVar 2.0: integrating genomic variant information from literature with dbSNP and ClinVar for precision medicine","volume":"34","author":"Wei","year":"2018","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t2019010803585727900_B41","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.1038\/s41598-018-25903-w","article-title":"A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease","volume":"8","author":"Martin","year":"2018","journal-title":"Sci. Rep."},{"key":"key\n\t\t\t\t2019010803585727900_B42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/humu.22727","article-title":"VariSNP, a benchmark database for variations from dbSNP","volume":"36","author":"Schaafsma","year":"2015","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t2019010803585727900_B43","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/nar\/29.1.308","article-title":"dbSNP: the NCBI database of genetic variation","volume":"29","author":"Sherry","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B44","doi-asserted-by":"crossref","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","article-title":"The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)","volume":"45","author":"MacArthur","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B45","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1021\/pr4005579","article-title":"Identification of enriched PTM crosstalk motifs from large-scale experimental data sets","volume":"13","author":"Peng","year":"2014","journal-title":"J. Proteome Res."},{"key":"key\n\t\t\t\t2019010803585727900_B46","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.1038\/s41598-018-25329-4","article-title":"Dissecting structure-encoded determinants of allosteric cross-talk between post-translational modification sites in the Hsp90 chaperones","volume":"8","author":"Stetz","year":"2018","journal-title":"Sci. Rep."},{"key":"key\n\t\t\t\t2019010803585727900_B47","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1021\/pr5001829","article-title":"Bioinformatic and proteomic analysis of bulk histones reveals PTM crosstalk and chromatin features","volume":"13","author":"Zhang","year":"2014","journal-title":"J. Proteome Res."},{"key":"key\n\t\t\t\t2019010803585727900_B48","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1074\/mcp.M115.054460","article-title":"Systems level analysis of histone H3 post-translational modifications (PTMs) reveals features of PTM crosstalk in chromatin regulation","volume":"15","author":"Schwammle","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"key\n\t\t\t\t2019010803585727900_B49","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.molcel.2008.07.002","article-title":"Lysine acetylation: codified crosstalk with other posttranslational modifications","volume":"31","author":"Yang","year":"2008","journal-title":"Mol. Cell"},{"issue":"Suppl. 1","key":"key\n\t\t\t\t2019010803585727900_B50","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1471-2105-16-S1-S1","article-title":"Characterization and identification of ubiquitin conjugation sites with E3 ligase recognition specificities","volume":"16","author":"Nguyen","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t2019010803585727900_B51","doi-asserted-by":"crossref","first-page":"e0118752","DOI":"10.1371\/journal.pone.0118752","article-title":"GSHSite: exploiting an iteratively statistical method to identify s-glutathionylation sites with substrate specificity","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"issue":"Suppl. 16","key":"key\n\t\t\t\t2019010803585727900_B52","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1471-2105-15-S16-S1","article-title":"Characterization and identification of protein O-GlcNAcylation sites with substrate specificity","volume":"15","author":"Wu","year":"2014","journal-title":"BMC Bioinformatics"},{"issue":"Suppl. 16","key":"key\n\t\t\t\t2019010803585727900_B53","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/1471-2105-14-S16-S10","article-title":"ViralPhos: incorporating a recursively statistical method to predict phosphorylation sites on virus proteins","volume":"14","author":"Huang","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t2019010803585727900_B54","doi-asserted-by":"crossref","first-page":"e40694","DOI":"10.1371\/journal.pone.0040694","article-title":"Identifying protein phosphorylation sites with kinase substrate specificity on human viruses","volume":"7","author":"Bretana","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019010803585727900_B55","doi-asserted-by":"crossref","first-page":"e21849","DOI":"10.1371\/journal.pone.0021849","article-title":"SNOSite: exploiting maximal dependence decomposition to identify cysteine S-nitrosylation with substrate site specificity","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019010803585727900_B56","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/1471-2105-12-261","article-title":"PlantPhos: using maximal dependence decomposition to identify plant phosphorylation sites with substrate site specificity","volume":"12","author":"Lee","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t2019010803585727900_B57","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1002\/jcc.21569","article-title":"N-Ace: using solvent accessibility and physicochemical properties to identify protein N-acetylation sites","volume":"31","author":"Lee","year":"2010","journal-title":"J. Comput. Chem."},{"key":"key\n\t\t\t\t2019010803585727900_B58","doi-asserted-by":"crossref","first-page":"W588","DOI":"10.1093\/nar\/gkm322","article-title":"KinasePhos 2.0: a web server for identifying protein kinase-specific phosphorylation sites based on sequences and coupling patterns","volume":"35","author":"Wong","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B59","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/jcc.20235","article-title":"Incorporating hidden Markov models for identifying protein kinase-specific phosphorylation sites","volume":"26","author":"Huang","year":"2005","journal-title":"J. Comput. Chem."},{"key":"key\n\t\t\t\t2019010803585727900_B60","doi-asserted-by":"crossref","first-page":"W226","DOI":"10.1093\/nar\/gki471","article-title":"KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites","volume":"33","author":"Huang","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B61","doi-asserted-by":"crossref","first-page":"D295","DOI":"10.1093\/nar\/gks1229","article-title":"DbPTM 3.0: an informative resource for investigating substrate site specificity and functional association of protein post-translational modifications","volume":"41","author":"Lu","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010803585727900_B62","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","article-title":"Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences","volume":"22","author":"Li","year":"2006","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t2019010803585727900_B63","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature24284","article-title":"Association analysis identifies 65 new breast cancer risk loci","volume":"551","author":"Michailidou","year":"2017","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019010803585727900_B64","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/ng.3002","article-title":"Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer","volume":"46","author":"Wang","year":"2014","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2019010803585727900_B65","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.sbi.2003.08.003","article-title":"Dynamic interplay between O-GlcNAc and O-phosphate: the sweet side of protein regulation","volume":"13","author":"Slawson","year":"2003","journal-title":"Curr. Opin. Struct. Biol."},{"key":"key\n\t\t\t\t2019010803585727900_B66","doi-asserted-by":"crossref","first-page":"E7255","DOI":"10.1073\/pnas.1620529114","article-title":"Elucidating crosstalk mechanisms between phosphorylation and O-GlcNAcylation","volume":"114","author":"Leney","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t2019010803585727900_B67","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1039\/b704905f","article-title":"O-GlcNAc modification in diabetes and Alzheimer's disease","volume":"3","author":"Dias","year":"2007","journal-title":"Mol. Biosyst."},{"key":"key\n\t\t\t\t2019010803585727900_B68","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1016\/S0021-9258(19)67706-9","article-title":"Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance","volume":"266","author":"Marshall","year":"1991","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t2019010803585727900_B69","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0014-5793(02)03774-2","article-title":"Glucosamine-induced insulin resistance is coupled to O-linked glycosylation of Munc18c","volume":"534","author":"Chen","year":"2003","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t2019010803585727900_B70","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bbrc.2013.12.023","article-title":"IRS1Ser(3)(0)(7) phosphorylation does not mediate mTORC1-induced insulin resistance","volume":"443","author":"Herrema","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t2019010803585727900_B71","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1471-2202-15-111","article-title":"Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats","volume":"15","author":"Spolcova","year":"2014","journal-title":"BMC Neurosci."},{"key":"key\n\t\t\t\t2019010803585727900_B72","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2337\/db12-0337","article-title":"Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes","volume":"62","author":"Mashili","year":"2013","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019010803585727900_B73","doi-asserted-by":"crossref","first-page":"E17","DOI":"10.1152\/ajpendo.90281.2008","article-title":"Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity","volume":"295","author":"Copeland","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"key\n\t\t\t\t2019010803585727900_B74","doi-asserted-by":"crossref","first-page":"E241","DOI":"10.1152\/ajpendo.00060.2002","article-title":"Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles","volume":"283","author":"Buse","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"key\n\t\t\t\t2019010803585727900_B75","doi-asserted-by":"crossref","first-page":"5313","DOI":"10.1073\/pnas.072072399","article-title":"Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes","volume":"99","author":"Vosseller","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/47\/D1\/D298\/27437398\/gky1074.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T08:16:57Z","timestamp":1662279417000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/47\/D1\/D298\/5168818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,10]]},"references-count":75,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2018,11,10]]},"published-print":{"date-parts":[[2019,1,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky1074","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1,8]]},"published":{"date-parts":[[2018,11,10]]}}}