{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:02:54Z","timestamp":1783699374300,"version":"3.55.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672113"],"award-info":[{"award-number":["81672113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670462"],"award-info":[{"award-number":["81670462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009977","name":"Fundamental Reseaarch Funds for Central Universies of China","doi-asserted-by":"publisher","award":["BMU2017YJ004"],"award-info":[{"award-number":["BMU2017YJ004"]}],"id":[{"id":"10.13039\/100009977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["C2018202083"],"award-info":[{"award-number":["C2018202083"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,2]]},"DOI":"10.1093\/nar\/gky509","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T15:11:17Z","timestamp":1527088277000},"page":"W180-W185","source":"Crossref","is-referenced-by-count":174,"title":["TAM 2.0: tool for MicroRNA set analysis"],"prefix":"10.1093","volume":"46","author":[{"given":"Jianwei","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"},{"name":"Department of Biomedical Informatics, School of Basic Medical Sciences, Center for Noncoding RNA Medicine, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Wan","sequence":"additional","affiliation":[{"name":"Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingshu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, School of Basic Medical Sciences, Center for Noncoding RNA Medicine, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, School of Basic Medical Sciences, Center for Noncoding RNA Medicine, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"key\n\t\t\t\t20180630061758_B1","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1242\/dev.02073","article-title":"MicroRNA functions in animal development and human disease","volume":"132","author":"Alvarez-Garcia","year":"2005","journal-title":"Development"},{"key":"key\n\t\t\t\t20180630061758_B2","doi-asserted-by":"crossref","first-page":"re3","DOI":"10.1126\/scisignal.2005825","article-title":"Dysregulation of microRNA biogenesis and gene silencing in cancer","volume":"8","author":"Hata","year":"2015","journal-title":"Sci. Signal."},{"key":"key\n\t\t\t\t20180630061758_B3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molmed.2012.10.006","article-title":"Could circulating miRNAs contribute to cancer therapy","volume":"19","author":"Chen","year":"2013","journal-title":"Trends Mol. Med."},{"key":"key\n\t\t\t\t20180630061758_B4","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1093\/eurheartj\/ehq167","article-title":"Circulating microRNAs are new and sensitive biomarkers of myocardial infarction","volume":"31","author":"D\u2019Alessandra","year":"2010","journal-title":"Eur. Heart J."},{"key":"key\n\t\t\t\t20180630061758_B5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/wrna.1320","article-title":"Can circulating miRNAs live up to the promise of being minimal invasive biomarkers in clinical settings","volume":"7","author":"Keller","year":"2016","journal-title":"Wiley Interdiscipl. Rev. RNA"},{"key":"key\n\t\t\t\t20180630061758_B6","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for annotation, visualization, and integrated discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20180630061758_B7","doi-asserted-by":"crossref","first-page":"40200","DOI":"10.1038\/srep40200","article-title":"MicroPattern: a web-based tool for microbe set enrichment analysis and disease similarity calculation based on a list of microbes","volume":"7","author":"Ma","year":"2017","journal-title":"Scientific Rep."},{"key":"key\n\t\t\t\t20180630061758_B8","doi-asserted-by":"crossref","first-page":"W83","DOI":"10.1093\/nar\/gkw199","article-title":"g:Profiler-a web server for functional interpretation of gene lists (2016 update)","volume":"44","author":"Reimand","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180630061758_B9","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1093\/nar\/gkv249","article-title":"Pathway analysis from lists of microRNAs: common pitfalls and alternative strategy","volume":"43","author":"Godard","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180630061758_B10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nmeth.3485","article-title":"miRWalk2.0: a comprehensive atlas of microRNA-target interactions","volume":"12","author":"Dweep","year":"2015","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20180630061758_B11","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","article-title":"miRWalk\u2013database: prediction of possible miRNA binding sites by \u201cwalking\u201d the genes of three genomes","volume":"44","author":"Dweep","year":"2011","journal-title":"J. Biomed. Inform."},{"key":"key\n\t\t\t\t20180630061758_B12","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3.0: deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180630061758_B13","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1093\/bioinformatics\/btv023","article-title":"Bias in microRNA functional enrichment analysis","volume":"31","author":"Bleazard","year":"2015","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180630061758_B14","doi-asserted-by":"crossref","first-page":"D1070","DOI":"10.1093\/nar\/gkt1023","article-title":"HMDD v2.0: a database for experimentally supported human microRNA and disease associations","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180630061758_B15","doi-asserted-by":"crossref","first-page":"D98","DOI":"10.1093\/nar\/gkn714","article-title":"miR2Disease: a manually curated database for microRNA deregulation in human disease","volume":"37","author":"Jiang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180630061758_B16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/1471-2105-11-419","article-title":"TAM: a method for enrichment and depletion analysis of a microRNA category in a list of microRNAs","volume":"11","author":"Lu","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180630061758_B17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.biosystems.2015.05.004","article-title":"miSEA: microRNA set enrichment analysis","volume":"134","author":"Corapcioglu","year":"2015","journal-title":"Biosystems"},{"key":"key\n\t\t\t\t20180630061758_B18","doi-asserted-by":"crossref","first-page":"W110","DOI":"10.1093\/nar\/gkw345","article-title":"miEAA: microRNA enrichment analysis and annotation","volume":"44","author":"Backes","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180630061758_B19","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"miRBase: annotating high confidence microRNAs using deep sequencing data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180630061758_B20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1261\/rna.7240905","article-title":"Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes","volume":"11","author":"Baskerville","year":"2005","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180630061758_B21","doi-asserted-by":"crossref","first-page":"D119","DOI":"10.1093\/nar\/gkp803","article-title":"TransmiR: a transcription factor-microRNA regulation database","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180630061758_B22","doi-asserted-by":"crossref","first-page":"D168","DOI":"10.1093\/nar\/gkx996","article-title":"mirTrans: a resource of transcriptional regulation on microRNAs for human cell lines","volume":"46","author":"Hua","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180630061758_B23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/bib\/bbw005","article-title":"An analysis of human microbe-disease associations","volume":"18","author":"Ma","year":"2017","journal-title":"Brief. Bioinformatics"},{"key":"key\n\t\t\t\t20180630061758_B24","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1038\/ncomms5212","article-title":"Human symptoms-disease network","volume":"5","author":"Zhou","year":"2014","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20180630061758_B25","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20180630061758_B26","first-page":"186716","article-title":"Use of miRNAs as biomarkers in sepsis","volume":"2015","author":"Dumache","year":"2015","journal-title":"Anal. Cell Pathol. (Amst)"},{"key":"key\n\t\t\t\t20180630061758_B27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/joim.12099","article-title":"miR-223: infection, inflammation and cancer","volume":"274","author":"Haneklaus","year":"2013","journal-title":"J. Internal Med."},{"key":"key\n\t\t\t\t20180630061758_B28","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3892\/ijmm.2015.2092","article-title":"MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis","volume":"35","author":"Katsura","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"key\n\t\t\t\t20180630061758_B29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12885-017-3300-y","article-title":"Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways","volume":"17","author":"Shimazu","year":"2017","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t20180630061758_B30","first-page":"1191","article-title":"Metformin use and its effect on gastric cancer in patients with type 2 diabetes: a systematic review of observational studies","volume":"15","author":"Li","year":"2018","journal-title":"Oncol. Lett."},{"key":"key\n\t\t\t\t20180630061758_B31","doi-asserted-by":"crossref","first-page":"W130","DOI":"10.1093\/nar\/gkx356","article-title":"WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/W1\/W180\/25110691\/gky509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T07:37:31Z","timestamp":1571384251000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/46\/W1\/W180\/5033528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,6]]},"references-count":31,"journal-issue":{"issue":"W1","published-online":{"date-parts":[[2018,6,6]]},"published-print":{"date-parts":[[2018,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky509","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7,2]]},"published":{"date-parts":[[2018,6,6]]}}}