{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:41:25Z","timestamp":1774672885832,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"D1","funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24 CA224370"],"award-info":[{"award-number":["U24 CA224370"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24 TR002278"],"award-info":[{"award-number":["U24 TR002278"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT3 HL142479"],"award-info":[{"award-number":["OT3 HL142479"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,8]]},"DOI":"10.1093\/nar\/gky963","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T07:45:10Z","timestamp":1540539910000},"page":"D963-D970","source":"Crossref","is-referenced-by-count":128,"title":["DrugCentral 2018: an update"],"prefix":"10.1093","volume":"47","author":[{"given":"Oleg","family":"Ursu","sequence":"first","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}]},{"given":"Jayme","family":"Holmes","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}]},{"given":"Cristian G","family":"Bologa","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}]},{"given":"Jeremy J","family":"Yang","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}]},{"given":"Stephen L","family":"Mathias","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}]},{"given":"Vasileios","family":"Stathias","sequence":"additional","affiliation":[{"name":"Center for Computational Science, Miller School of Medicine, University of Miami, Coral Gables, FL 33146, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-9948","authenticated-orcid":false,"given":"Dac-Trung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7180-0978","authenticated-orcid":false,"given":"Stephan","family":"Sch\u00fcrer","sequence":"additional","affiliation":[{"name":"Center for Computational Science, Miller School of Medicine, University of Miami, Coral Gables, FL 33146, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-6976","authenticated-orcid":false,"given":"Tudor","family":"Oprea","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}]}],"member":"286","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"key\n\t\t\t\t2019012510253788200_B1","doi-asserted-by":"crossref","first-page":"gkw993","DOI":"10.1093\/nar\/gkw993","article-title":"DrugCentral: online drug compendium","volume":"45","author":"Ursu","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019012510253788200_B2","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkw1074","article-title":"The ChEMBL database in 2017","volume":"45","author":"Gaulton","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019012510253788200_B3","doi-asserted-by":"crossref","first-page":"D1214","DOI":"10.1093\/nar\/gkv1031","article-title":"ChEBI in 2016: Improved services and an expanding collection of metabolites","volume":"44","author":"Hastings","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019012510253788200_B4","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019012510253788200_B5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nmeth.4365","article-title":"Probes & Drugs portal: an interactive, open data resource for chemical biology","volume":"14","author":"Skuta","year":"2017","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t2019012510253788200_B6","first-page":"1","article-title":"Pharos: Collating protein information to shed light on the druggable genome","volume":"45","author":"Nguyen","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019012510253788200_B7","doi-asserted-by":"crossref","first-page":"170029","DOI":"10.1038\/sdata.2017.29","article-title":"A standard database for drug repositioning","volume":"4","author":"Brown","year":"2017","journal-title":"Sci. Data"},{"key":"key\n\t\t\t\t2019012510253788200_B8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2016.230","article-title":"A comprehensive map of molecular drug targets","volume":"16","author":"Santos","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"key\n\t\t\t\t2019012510253788200_B9","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity Map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019012510253788200_B10","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1016\/j.ejmech.2010.06.026","article-title":"Extending pKa prediction accuracy: High-throughput pK a measurements to understand pKa modulation of new chemical series","volume":"45","author":"Milletti","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"key\n\t\t\t\t2019012510253788200_B11","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: A major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019012510253788200_B12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1758-2946-5-3","article-title":"UniChem: A unified chemical structure cross-referencing and identifier tracking system","volume":"5","author":"Chambers","year":"2013","journal-title":"J. Cheminform."},{"key":"key\n\t\t\t\t2019012510253788200_B13","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019012510253788200_B14","doi-asserted-by":"crossref","first-page":"D1091","DOI":"10.1093\/nar\/gkx1121","article-title":"The IUPHAR\/BPS Guide to Pharmacology in 2018: Updates and expansion to encompass the new guide to immunopharmacology","volume":"46","author":"Harding","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019012510253788200_B15","first-page":"252","article-title":"The multiplicity of serotonin receptors: Uselessly diverse molecules or an embarrassment of riches?","volume":"6","author":"Roth","year":"2000","journal-title":"Neurosci."},{"key":"key\n\t\t\t\t2019012510253788200_B16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrd.2018.14","article-title":"Unexplored therapeutic opportunities in the human genome","volume":"17","author":"Oprea","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"key\n\t\t\t\t2019012510253788200_B17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vascn.2008.05.007","article-title":"Safety and secondary pharmacology: Successes, threats, challenges and opportunities","volume":"58","author":"Valentin","year":"2008","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"key\n\t\t\t\t2019012510253788200_B18","doi-asserted-by":"crossref","DOI":"10.1109\/I-SPAN.2009.84","article-title":"Medical terminologies that work: the example of MeSH","author":"Nelson","year":"2009"},{"key":"key\n\t\t\t\t2019012510253788200_B19","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1093\/bioinformatics\/bts186","article-title":"e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design","volume":"28","author":"Pihan","year":"2012","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t2019012510253788200_B20","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1198\/jasa.2011.ap10243","article-title":"A likelihood ratio test based method for signal detection with application to FDA\u2019s drug safety data","volume":"106","author":"Huang","year":"2011","journal-title":"J. Am. Stat. Assoc."},{"key":"key\n\t\t\t\t2019012510253788200_B21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1039\/C2CS35348B","article-title":"The significance of acid\/base properties in drug discovery","volume":"42","author":"Manallack","year":"2013","journal-title":"Chem. Soc. Rev."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/47\/D1\/D963\/27436360\/gky963.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T12:59:10Z","timestamp":1572267550000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/47\/D1\/D963\/5146206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,29]]},"references-count":21,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2018,10,29]]},"published-print":{"date-parts":[[2019,1,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky963","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734312262.793553418","asserted-by":"object"}]},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1,8]]},"published":{"date-parts":[[2018,10,29]]}}}