{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:26:49Z","timestamp":1784618809156,"version":"3.55.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830111"],"award-info":[{"award-number":["81830111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330086"],"award-info":[{"award-number":["81330086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473414"],"award-info":[{"award-number":["81473414"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673834"],"award-info":[{"award-number":["81673834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21772005"],"award-info":[{"award-number":["21772005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key project at central government","award":["2060302"],"award-info":[{"award-number":["2060302"]}]},{"name":"Program of China","award":["2015CB554406"],"award-info":[{"award-number":["2015CB554406"]}]},{"name":"National Key Technology R&D Program of China","award":["2011BAI07B08"],"award-info":[{"award-number":["2011BAI07B08"]}]},{"name":"National Key Technology R&D Program of China","award":["2016YFC 0903001"],"award-info":[{"award-number":["2016YFC 0903001"]}]},{"name":"Central public welfare research institutes","award":["L2017018"],"award-info":[{"award-number":["L2017018"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YFC1702104"],"award-info":[{"award-number":["2017YFC1702104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YFC1702303"],"award-info":[{"award-number":["2017YFC1702303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,8]]},"DOI":"10.1093\/nar\/gky987","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T11:08:53Z","timestamp":1540033733000},"page":"D976-D982","source":"Crossref","is-referenced-by-count":738,"title":["ETCM: an encyclopaedia of traditional Chinese medicine"],"prefix":"10.1093","volume":"47","author":[{"given":"Hai-Yu","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"},{"name":"National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Chen","sequence":"additional","affiliation":[{"name":"National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Yu","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Huan","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yong","family":"Li","sequence":"additional","affiliation":[{"name":"China Minority Traditional Medical Center, Minzu University of China, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Rong","family":"Zhou","sequence":"additional","affiliation":[{"name":"China Minority Traditional Medical Center, Minzu University of China, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Networks, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Qi","family":"Huang","sequence":"additional","affiliation":[{"name":"National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"key\n\t\t\t\t2019010800482364900_B1","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1038\/480S82a","article-title":"TCM: Made in China","volume":"480","author":"Cheung","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019010800482364900_B2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2174\/1386207320666170116141818","article-title":"Anticancer properties of traditional chinese medicine","volume":"20","author":"Yan","year":"2017","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"key\n\t\t\t\t2019010800482364900_B3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12016-012-8332-0","article-title":"Traditional Chinese medicine and immune regulation","volume":"44","author":"Ma","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"key\n\t\t\t\t2019010800482364900_B4","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s11427-015-4948-7","article-title":"The discovery of artemisinin and the nobel prize in physiology or medicine","volume":"58","author":"Su","year":"2015","journal-title":"Sci. China Life Sci."},{"key":"key\n\t\t\t\t2019010800482364900_B5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1517\/17460441.2013.739602","article-title":"The application of Chinese medicine to novel drug discovery","volume":"8","author":"Sucher","year":"2013","journal-title":"Expert Opin Drug Discov."},{"key":"key\n\t\t\t\t2019010800482364900_B6","first-page":"S72","article-title":"Mapping ancient remedies: applying a network approach to traditional Chinese medicine","volume":"350","author":"LI","year":"2015","journal-title":"Sponsored Suppl. Sci."},{"key":"key\n\t\t\t\t2019010800482364900_B7","doi-asserted-by":"crossref","first-page":"D1055","DOI":"10.1093\/nar\/gkq1165","article-title":"HIT: linking herbal active ingredientsto targets","volume":"39","author":"Ye","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800482364900_B8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1472-6882-8-58","article-title":"TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining","volume":"8","author":"Fang","year":"2008","journal-title":"BMC Complement. Altern. Med."},{"key":"key\n\t\t\t\t2019010800482364900_B9","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1038\/s41598-017-03039-7","article-title":"TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"key\n\t\t\t\t2019010800482364900_B10","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjp.0706945","article-title":"Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation","volume":"149","author":"Chen","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"key\n\t\t\t\t2019010800482364900_B11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform."},{"key":"key\n\t\t\t\t2019010800482364900_B12","doi-asserted-by":"crossref","first-page":"D1117","DOI":"10.1093\/nar\/gkx1028","article-title":"TCMID 2.0: a comprehensive resource for TCM","volume":"46","author":"Huang","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800482364900_B13","doi-asserted-by":"crossref","first-page":"D1089","DOI":"10.1093\/nar\/gks1100","article-title":"TCMID: traditional Chinese medicine integrative database for herb molecular mechanism analysis","volume":"41","author":"Xue","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800482364900_B14","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nchem.1243","article-title":"Quantifying the chemical beauty of drugs","volume":"4","author":"Bickerton","year":"2012","journal-title":"Nat. Chem."},{"key":"key\n\t\t\t\t2019010800482364900_B15","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1021\/acs.jmedchem.5b01286","article-title":"How Beyond rule of 5 drugs and clinical candidates bind to their targets","volume":"59","author":"Doak","year":"2016","journal-title":"J. Med. Chem."},{"key":"key\n\t\t\t\t2019010800482364900_B16","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.chembiol.2014.08.013","article-title":"Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates","volume":"21","author":"Doak","year":"2014","journal-title":"Chem. Biol."},{"key":"key\n\t\t\t\t2019010800482364900_B17","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800482364900_B18","doi-asserted-by":"crossref","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","article-title":"Gene ontology consortium: going forward","volume":"43","author":"Gene Ontology Consortium","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800482364900_B19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyotoencyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019010800482364900_B20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13321-017-0248-5","article-title":"Consensus queries in ligand-based virtual screening experiments","volume":"9","author":"Berenger","year":"2017","journal-title":"J. Cheminform."},{"key":"key\n\t\t\t\t2019010800482364900_B21","first-page":"515","article-title":"Comparison of ligand-, target structure-, and protein-ligand interaction Fingerprint-based virtual screening methods","volume":"5","author":"Huang","year":"2011","journal-title":"Acta Chim. Sinica"},{"key":"key\n\t\t\t\t2019010800482364900_B22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nbt.1549","article-title":"Synergistic drug combinations tend to improve therapeutically relevant selectivity","volume":"27","author":"Leh\u00e1r","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t2019010800482364900_B23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fphar.2016.00201","article-title":"Synergistic effects of chinese herbal medicine: a comprehensive review of methodology and current research","volume":"7","author":"Zhou","year":"2016","journal-title":"Front. Pharmacol."},{"key":"key\n\t\t\t\t2019010800482364900_B24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/aps.2014.125","article-title":"Diverse array-designed modes of combination therapies in Fangjiomics","volume":"36","author":"Liu","year":"2015","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/47\/D1\/D976\/27436355\/gky987.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T08:04:28Z","timestamp":1589961868000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/47\/D1\/D976\/5144966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":24,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2018,10,26]]},"published-print":{"date-parts":[[2019,1,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky987","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1,8]]},"published":{"date-parts":[[2018,10,26]]}}}