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Databases facilitate data interpretation for underlying mechanisms. Here, we describe the Virtual Metabolic Human (VMH, www.vmh.life) database encapsulating current knowledge of human metabolism within five interlinked resources \u2018Human metabolism\u2019, \u2018Gut microbiome\u2019, \u2018Disease\u2019, \u2018Nutrition\u2019, and \u2018ReconMaps\u2019. The VMH captures 5180 unique metabolites, 17 730 unique reactions, 3695\u00a0human genes, 255 Mendelian diseases, 818 microbes, 632 685 microbial genes and 8790 food items. The VMH\u2019s unique features are (i) the hosting of the metabolic reconstructions of human and gut microbes amenable for metabolic modeling; (ii) seven human metabolic maps for data visualization; (iii) a nutrition designer; (iv) a user-friendly webpage and application-programming interface to access its content; (v) user feedback option for community engagement and (vi) the connection of its entities to 57 other web resources. The VMH represents a novel, interdisciplinary database for data interpretation and hypothesis generation to the biomedical community.<\/jats:p>","DOI":"10.1093\/nar\/gky992","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T03:06:39Z","timestamp":1539140799000},"page":"D614-D624","source":"Crossref","is-referenced-by-count":374,"title":["The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease"],"prefix":"10.1093","volume":"47","author":[{"given":"Alberto","family":"Noronha","sequence":"first","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg , Campus Belval, Esch-sur-Alzette L-4367, Luxembourg"}]},{"given":"Jennifer","family":"Modamio","sequence":"first","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg , Campus Belval, Esch-sur-Alzette L-4367, 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