{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:59:22Z","timestamp":1768564762444,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/igo\/"}],"funder":[{"name":"EXPOsOMICS FP7-KBBE-2012","award":["308610"],"award-info":[{"award-number":["308610"]}]},{"name":"Joint Programming Initiative FOODBALL"},{"DOI":"10.13039\/100008700","name":"International Agency for Research on Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Exposome-Explorer (http:\/\/exposome-explorer.iarc.fr) is a database of dietary and pollutant biomarkers measured in population studies. In its first release, Exposome-Explorer contained comprehensive information on 692 biomarkers of dietary and pollution exposures extracted from the analysis of 480 peer-reviewed publications. Today, Exposome-Explorer has been further expanded and contains a total of 908 biomarkers. Two additional types of information have been collected. First, 185 candidate dietary biomarkers having 403 associations with food intake (as measured by metabolomic studies) have been identified and added. Second, 1356 associations between dietary biomarkers and cancer risk in epidemiological studies, which were collected from 313 publications, have also been added to the database. Classifications for both foods and compounds have been revised, and new classifications for biospecimens, analytical methods and cancers have been implemented. Finally, the web interface has been redesigned to significantly improve the user experience.<\/jats:p>","DOI":"10.1093\/nar\/gkz1009","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T15:11:40Z","timestamp":1573485100000},"source":"Crossref","is-referenced-by-count":29,"title":["Exposome-Explorer 2.0: an update incorporating candidate dietary biomarkers and dietary associations with cancer risk"],"prefix":"10.1093","author":[{"given":"Vanessa","family":"Neveu","sequence":"first","affiliation":[{"name":"International Agency for Research on Cancer (IARC), Nutrition and Metabolism Section, Biomarkers Group, 150 Cours Albert Thomas, F-69372 Lyon Cedex 08, France"}]},{"given":"Genevi\u00e8ve","family":"Nicolas","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer (IARC), Nutrition and Metabolism Section, Biomarkers Group, 150 Cours Albert Thomas, F-69372 Lyon Cedex 08, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8604-1732","authenticated-orcid":false,"given":"Reza M","family":"Salek","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer (IARC), Nutrition and Metabolism Section, Biomarkers Group, 150 Cours Albert Thomas, F-69372 Lyon Cedex 08, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-2434","authenticated-orcid":false,"given":"David S","family":"Wishart","sequence":"additional","affiliation":[{"name":"Department of Computing Science, University of Alberta, Edmonton, AB T6G 2E8, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-6710","authenticated-orcid":false,"given":"Augustin","family":"Scalbert","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer (IARC), Nutrition and Metabolism Section, Biomarkers Group, 150 Cours Albert Thomas, F-69372 Lyon Cedex 08, France"}]}],"member":"286","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"2019111404483748800_B1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/jnci\/66.6.1192","article-title":"The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today","volume":"66","author":"Doll","year":"1981","journal-title":"J. Natl. Cancer Inst."},{"key":"2019111404483748800_B2","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1158\/0008-5472.CAN-09-0416","article-title":"Landmarks in the history of cancer epidemiology","volume":"69","author":"Greenwald","year":"2009","journal-title":"Cancer Res."},{"key":"2019111404483748800_B3","volume-title":"Nutrition in the Prevention and Treatment of Disease","author":"Thompson","year":"2008"},{"key":"2019111404483748800_B4","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1158\/1055-9965.EPI-05-0456","article-title":"Complementing the genome with an \u201cexposome\u201d: The outstanding challenge of environmental exposure measurement in molecular epidemiology","volume":"14","author":"Wild","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"2019111404483748800_B5","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/em.21777","article-title":"Measuring the Exposome: a powerful basis for evaluating environmental exposures and cancer risk","volume":"54","author":"Wild","year":"2013","journal-title":"Environ. Mol. Mutagen."},{"key":"2019111404483748800_B6","doi-asserted-by":"crossref","first-page":"D979","DOI":"10.1093\/nar\/gkw980","article-title":"Exposome-Explorer: a manually-curated database on biomarkers of exposure to dietary and environmental factors","volume":"45","author":"Neveu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2019111404483748800_B7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1017\/S002966511600032X","article-title":"Metabolomics as a tool in the identification of dietary biomarkers","volume":"76","author":"Gibbons","year":"2017","journal-title":"Proc. Nutr. 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Nutr."},{"key":"2019111404483748800_B9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1201\/9781315152288-15","volume-title":"Advances in the Assessment of Dietary Intake","author":"Scalbert","year":"2017"},{"key":"2019111404483748800_B10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"2019111404483748800_B11","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.4155\/bio.11.155","article-title":"Advances in metabolite identification","volume":"3","author":"Wishart","year":"2011","journal-title":"Bioanalysis"},{"key":"2019111404483748800_B12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13321-016-0174-y","article-title":"ClassyFire: automated chemical classification with a comprehensive, computable taxonomy","volume":"8","author":"Djoumbou\u00a0Feunang","year":"2016","journal-title":"J. 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