{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:08:12Z","timestamp":1781651292948,"version":"3.54.5"},"reference-count":70,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","award":["204562"],"award-info":[{"award-number":["204562"]}],"id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Israel Innovation Authority","award":["66824"],"award-info":[{"award-number":["66824"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chimeric RNA transcripts are formed when exons from two genes fuse together, often due to chromosomal translocations, transcriptional errors or trans-splicing effect. While these chimeric RNAs produce functional proteins only in certain cases, they play a significant role in disease phenotyping and progression. ChiTaRS 5.0 (http:\/\/chitars.md.biu.ac.il\/) is the latest and most comprehensive chimeric transcript repository, with 111\u00a0582 annotated entries from eight species, including 23\u00a0167 known human cancer breakpoints. The database includes unique information correlating chimeric breakpoints with 3D chromatin contact maps, generated from public datasets of chromosome conformation capture techniques (Hi\u2013C). In this update, we have added curated information on druggable fusion targets matched with chimeric breakpoints, which are applicable to precision medicine in cancers. The introduction of a new section that lists chimeric RNAs in various cell-lines is another salient feature. Finally, using text-mining techniques, novel chimeras in Alzheimer's disease, schizophrenia, dyslexia and other diseases were collected in ChiTaRS. Thus, this improved version is an extensive catalogue of chimeras from multiple species. It extends our understanding of the evolution of chimeric transcripts in eukaryotes and contributes to the analysis of 3D genome conformational changes and the functional role of chimeras in the etiopathogenesis of cancers and other complex diseases.<\/jats:p>","DOI":"10.1093\/nar\/gkz1025","type":"journal-article","created":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T19:08:38Z","timestamp":1572116918000},"source":"Crossref","is-referenced-by-count":9,"title":["ChiTaRS 5.0: the comprehensive database of chimeric transcripts matched with druggable fusions and 3D chromatin maps"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8669-0150","authenticated-orcid":false,"given":"Deepak","family":"Balamurali","sequence":"first","affiliation":[{"name":"Laboratory of Cancer Genomics and Biocomputing of Complex Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed\u00a01311502, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4126-9781","authenticated-orcid":false,"given":"Alessandro","family":"Gorohovski","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Genomics and Biocomputing of Complex Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed\u00a01311502, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Detroja","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Genomics and Biocomputing of Complex Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed\u00a01311502, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Palande","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Genomics and Biocomputing of Complex Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed\u00a01311502, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorith","family":"Raviv-Shay","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Genomics and Biocomputing of Complex Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed\u00a01311502, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milana","family":"Frenkel-Morgenstern","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Genomics and Biocomputing of Complex Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed\u00a01311502, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"2019112010001773400_B1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nature05874","article-title":"Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project","volume":"447","author":"Birney","year":"2007","journal-title":"Nature"},{"issue":"Suppl. 1","key":"2019112010001773400_B2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/gb-2006-7-s1-s2","article-title":"EGASP: the human ENCODE Genome annotation assessment project","volume":"7","author":"Guig\u00f3","year":"2006","journal-title":"Genome Biol."},{"key":"2019112010001773400_B3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"2019112010001773400_B4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0092-8674(00)81845-0","article-title":"Characterization of the yeast transcriptome","volume":"88","author":"Velculescu","year":"1997","journal-title":"Cell"},{"key":"2019112010001773400_B5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1074\/mcp.M200001-MCP200","article-title":"Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae","volume":"1","author":"Griffin","year":"2002","journal-title":"Mol. 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