{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T19:11:33Z","timestamp":1760987493979,"version":"3.41.2"},"reference-count":57,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701143","31871327"],"award-info":[{"award-number":["31701143","31871327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"publisher","award":["18JCZDJC34700"],"award-info":[{"award-number":["18JCZDJC34700"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genome-wide association studies (GWASs) have revolutionized the field of complex trait genetics over the past decade, yet for most of the significant genotype-phenotype associations the true causal variants remain unknown. Identifying and interpreting how causal genetic variants confer disease susceptibility is still a big challenge. Herein we introduce a new database, CAUSALdb, to integrate the most comprehensive GWAS summary statistics to date and identify credible sets of potential causal variants using uniformly processed fine-mapping. The database has six major features: it (i) curates 3052 high-quality, fine-mappable GWAS summary statistics across five human super-populations and 2629 unique traits; (ii) estimates causal probabilities of all genetic variants in GWAS significant loci using three state-of-the-art fine-mapping tools; (iii) maps the reported traits to a powerful ontology MeSH, making it simple for users to browse studies on the trait tree; (iv) incorporates highly interactive Manhattan and LocusZoom-like plots to allow visualization of credible sets in a single web page more efficiently; (v) enables online comparison of causal relations on variant-, gene-\u00a0and trait-levels among studies with different sample sizes or populations and (vi) offers comprehensive variant annotations by integrating massive base-wise and allele-specific functional annotations. CAUSALdb is freely available at http:\/\/mulinlab.org\/causaldb.<\/jats:p>","DOI":"10.1093\/nar\/gkz1026","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T19:20:39Z","timestamp":1571685639000},"source":"Crossref","is-referenced-by-count":13,"title":["CAUSALdb: a database for disease\/trait causal variants identified using summary statistics of genome-wide association studies"],"prefix":"10.1093","author":[{"given":"Jianhua","family":"Wang","sequence":"first","affiliation":[{"name":"2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China"},{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}]},{"given":"Dandan","family":"Huang","sequence":"additional","affiliation":[{"name":"2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China"},{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}]},{"given":"Yao","family":"Zhou","sequence":"additional","affiliation":[{"name":"2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China"},{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}]},{"given":"Hongcheng","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"}]},{"given":"Huanhuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}]},{"given":"Sinan","family":"Zhai","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Tianjin Medical University, Tianjin, China"}]},{"given":"Chengwei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Tianjin Medical University, Tianjin, China"}]},{"given":"Zhanye","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}]},{"given":"Ke","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}]},{"given":"Xianfu","family":"Yi","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Tianjin Medical University, Tianjin, China"}]},{"given":"Shijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}]},{"given":"Xiaorong","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical laboratory, Institute of Pediatrics, Shenzhen Children's Hospital, Shenzhen, China"}]},{"given":"Zipeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre of Genomics Sciences, State Key Laboratory of Brain and Cognitive Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"}]},{"given":"Kexin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Tianjin Key Laboratory of Molecular Cancer Epidemiology, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}]},{"given":"Pak Chung","family":"Sham","sequence":"additional","affiliation":[{"name":"Centre of Genomics Sciences, State Key Laboratory of Brain and Cognitive Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-3679","authenticated-orcid":false,"given":"Mulin Jun","family":"Li","sequence":"additional","affiliation":[{"name":"2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China"},{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"},{"name":"Department of Epidemiology and Biostatistics, Tianjin Key Laboratory of Molecular Cancer Epidemiology, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China"}]}],"member":"286","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"key":"2019110606360277800_B1","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.ophtha.2006.10.035","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"114","author":"Narayanan","year":"2007","journal-title":"Ophthalmology"},{"key":"2019110606360277800_B2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrg2796","article-title":"Genotype imputation for genome-wide association studies","volume":"11","author":"Marchini","year":"2010","journal-title":"Nat. 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