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From the literature, we manually collected 150 scaffold proteins that are drivers of LLPS, 987 regulators that contribute in modulating LLPS, and 8148 potential client proteins that might be dispensable for the formation of MLOs, which were then categorized into 40 biomolecular condensates. We searched potential orthologs of these known proteins, and in total DrLLPS contained 437 887 known and potential LLPS-associated proteins in 164 eukaryotes. Furthermore, we carefully annotated LLPS-associated proteins in eight model organisms, by using the knowledge integrated from 110 widely used resources that covered 16 aspects, including protein disordered regions, domain annotations, post-translational modifications (PTMs), genetic variations, cancer mutations, molecular interactions, disease-associated information, drug-target relations, physicochemical property, protein functional annotations, protein expressions\/proteomics, protein 3D structures, subcellular localizations, mRNA expressions, DNA &amp; RNA elements, and DNA methylations. We anticipate DrLLPS can serve as a helpful resource for further analysis of LLPS.<\/jats:p>","DOI":"10.1093\/nar\/gkz1027","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T19:20:39Z","timestamp":1571685639000},"page":"D288-D295","source":"Crossref","is-referenced-by-count":202,"title":["DrLLPS: a data resource of liquid\u2013liquid phase separation in eukaryotes"],"prefix":"10.1093","volume":"48","author":[{"given":"Wanshan","family":"Ning","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and 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