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To date, several SE databases have been developed by us and others. However, these existing databases do not provide downstream or upstream regulatory analyses of SEs. Pathways, transcription factors (TFs), SEs, and SE-associated genes form complex regulatory networks. Therefore, we designed a novel web server, SEanalysis, which provides comprehensive SE-associated regulatory network analyses. SEanalysis characterizes SE-associated genes, TFs binding to target SEs, and their upstream pathways. The current version of SEanalysis contains more than 330 000 SEs from more than 540 types of cells\/tissues, 5042 TF ChIP-seq data generated from these cells\/tissues, DNA-binding sequence motifs for \u223c700 human TFs and 2880 pathways from 10 databases. SEanalysis supports searching by either SEs, samples, TFs, pathways or genes. The complex regulatory networks formed by these factors can be interactively visualized. In addition, we developed a customizable genome browser containing &gt;6000 customizable tracks for visualization. The server is freely available at http:\/\/licpathway.net\/SEanalysis.<\/jats:p>","DOI":"10.1093\/nar\/gkz302","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T07:23:38Z","timestamp":1555572218000},"page":"W248-W255","source":"Crossref","is-referenced-by-count":42,"title":["SEanalysis: a web tool for super-enhancer associated regulatory analysis"],"prefix":"10.1093","volume":"47","author":[{"given":"Feng-Cui","family":"Qian","sequence":"first","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Xue-Cang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Jin-Cheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Oncologic Pathology, Medical College of Shantou University, Shantou 515041, China"}]},{"given":"Jian-Mei","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Yan-Yu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Zhi-Dong","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Li-Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Xue-Feng","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Qi","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Qiu-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Oncologic Pathology, Medical College of Shantou University, Shantou 515041, China"},{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"En-Min","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"given":"Chun-Quan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-4292","authenticated-orcid":false,"given":"Li-Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Oncologic Pathology, Medical College of Shantou University, Shantou 515041, China"}]},{"given":"De-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China"}]}],"member":"286","published-online":{"date-parts":[[2019,4,27]]},"reference":[{"key":"2019062808130523400_B1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"key":"2019062808130523400_B2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","article-title":"Master transcription factors and mediator establish super-enhancers at key cell identity genes","volume":"153","author":"Whyte","year":"2013","journal-title":"Cell"},{"key":"2019062808130523400_B3","doi-asserted-by":"crossref","first-page":"17921","DOI":"10.1073\/pnas.1317023110","article-title":"Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants","volume":"110","author":"Parker","year":"2013","journal-title":"Proc. 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