{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:53:36Z","timestamp":1771062816889,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81322046"],"award-info":[{"award-number":["81322046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473137"],"award-info":[{"award-number":["81473137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91753117"],"award-info":[{"award-number":["91753117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81721004"],"award-info":[{"award-number":["81721004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1605221"],"award-info":[{"award-number":["U1605221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC0310900"],"award-info":[{"award-number":["2018YFC0310900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["2019-01-07-00-01-E00036"],"award-info":[{"award-number":["2019-01-07-00-01-E00036"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Science and Technology Innovation","award":["19431901600"],"award-info":[{"award-number":["19431901600"]}]},{"name":"Shanghai Sailing Program","award":["16YF1406500"],"award-info":[{"award-number":["16YF1406500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Identifying the variants that alter protein function is a promising strategy for deciphering the biological consequences of somatic mutations during tumorigenesis, which could provide novel targets for the development of cancer therapies. Here, based on our previously developed method, we present a strategy called AlloDriver that identifies cancer driver genes\/proteins as possible targets from mutations. AlloDriver utilizes structural and dynamic features to prioritize potentially functional genes\/proteins in individual cancers via mapping mutations generated from clinical cancer samples to allosteric\/orthosteric sites derived from three-dimensional protein structures. This strategy exhibits desirable performance in the reemergence of known cancer driver mutations and genes\/proteins from clinical samples. Significantly, the practicability of AlloDriver to discover novel cancer driver proteins in head and neck squamous cell carcinoma (HNSC) was tested in a real case of human protein tyrosine phosphatase, receptor type K (PTPRK) through a L1143F driver mutation located at the allosteric site of PTPRK, which was experimentally validated by cell proliferation assay. AlloDriver is expected to help to uncover innovative molecular mechanisms of tumorigenesis by perturbing proteins and to discover novel targets based on cancer driver mutations. The AlloDriver is freely available to all users at http:\/\/mdl.shsmu.edu.cn\/ALD.<\/jats:p>","DOI":"10.1093\/nar\/gkz350","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T15:20:13Z","timestamp":1556205613000},"page":"W315-W321","source":"Crossref","is-referenced-by-count":39,"title":["AlloDriver: a method for the identification and analysis of cancer driver targets"],"prefix":"10.1093","volume":"47","author":[{"given":"Kun","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Clinical and Fundamental Research Center, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"},{"name":"Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Clinical and Fundamental Research Center, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"},{"name":"Medicinal Bioinformatics Center, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7836-2851","authenticated-orcid":false,"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Department of Otolaryngology Head & Neck Surgery, the First Hospital, Shanxi Medical University, Taiyuan, Shanxi\u00a0030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyong","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Clinical and Fundamental Research Center, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiancheng","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Clinical and Fundamental Research Center, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"},{"name":"Medicinal Bioinformatics Center, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Clinical and Fundamental Research Center, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"},{"name":"Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Department of Otolaryngology Head & Neck Surgery, the First Hospital, Shanxi Medical University, Taiyuan, Shanxi\u00a0030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binquan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Department of Otolaryngology Head & Neck Surgery, the First Hospital, Shanxi Medical University, Taiyuan, Shanxi\u00a0030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houwen","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Clinical and Fundamental Research Center, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"},{"name":"Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-791X","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Clinical and Fundamental Research Center, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"},{"name":"Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200127, China"},{"name":"Medicinal Bioinformatics Center, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200025, China"},{"name":"Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai\u00a0200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"2019062808124605600_B1","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1204040","article-title":"Exploring the genomes of cancer cells: progress and promise","volume":"331","author":"Stratton","year":"2011","journal-title":"Science"},{"key":"2019062808124605600_B2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cell.2018.02.060","article-title":"Comprehensive characterization of cancer driver genes and mutations","volume":"173","author":"Bailey","year":"2018","journal-title":"Cell"},{"key":"2019062808124605600_B3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2018.03.035","article-title":"Oncogenic signaling pathways in the cancer genome atlas","volume":"173","author":"Sanchez-Vega","year":"2018","journal-title":"Cell"},{"key":"2019062808124605600_B4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.sbi.2015.01.004","article-title":"\u2018Latent drivers\u2019 expand the cancer mutational landscape","volume":"32","author":"Nussinov","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2019062808124605600_B5","doi-asserted-by":"crossref","first-page":"D256","DOI":"10.1093\/nar\/gkw905","article-title":"mutLBSgeneDB: mutated ligand binding site gene DataBase","volume":"45","author":"Kim","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B6","doi-asserted-by":"crossref","first-page":"D895","DOI":"10.1093\/nar\/gky1098","article-title":"Cancer3D 2.0: interactive analysis of 3D patterns of cancer mutations in cancer subsets","volume":"47","author":"Sedova","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cell.2013.03.034","article-title":"Allostery in disease and in drug discovery","volume":"153","author":"Nussinov","year":"2013","journal-title":"Cell"},{"key":"2019062808124605600_B8","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cell.2016.08.015","article-title":"Allosteric modulation as a unifying mechanism for receptor function and regulation","volume":"166","author":"Changeux","year":"2016","journal-title":"Cell"},{"key":"2019062808124605600_B9","doi-asserted-by":"crossref","first-page":"e1003559","DOI":"10.1371\/journal.pcbi.1003559","article-title":"Chemical, target, and bioactive properties of allosteric modulation","volume":"10","author":"van\u00a0Westen","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"2019062808124605600_B10","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/s41589-018-0150-0","article-title":"Identification of a cellularly active SIRT6 allosteric activator","volume":"14","author":"Huang","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"2019062808124605600_B11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1021\/acs.jmedchem.7b01844","article-title":"Small molecule allosteric modulators of G-protein-coupled receptors: drug\u2013target interactions","volume":"62","author":"Lu","year":"2018","journal-title":"J. Med. Chem."},{"key":"2019062808124605600_B12","doi-asserted-by":"crossref","first-page":"D265","DOI":"10.1093\/nar\/gky1028","article-title":"AlloMAPS: allosteric mutation analysis and polymorphism of signaling database","volume":"47","author":"Tan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.sbi.2018.10.008","article-title":"On the perturbation nature of allostery: sites, mutations, and signal modulation","volume":"56","author":"Guarnera","year":"2019","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2019062808124605600_B14","doi-asserted-by":"crossref","first-page":"e1004678","DOI":"10.1371\/journal.pcbi.1004678","article-title":"Structure-Based statistical mechanical model accounts for the causality and energetics of allosteric communication","volume":"12","author":"Guarnera","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"2019062808124605600_B15","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1021\/acs.biochem.6b00783","article-title":"Toward allosterically increased catalytic activity of Insulin-Degrading enzyme against amyloid peptides","volume":"56","author":"Kurochkin","year":"2017","journal-title":"Biochemistry"},{"key":"2019062808124605600_B16","doi-asserted-by":"crossref","first-page":"17692","DOI":"10.1021\/ja510028c","article-title":"Principles of allosteric interactions in cell signaling","volume":"136","author":"Nussinov","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"2019062808124605600_B17","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1093\/bioinformatics\/btx430","article-title":"AlloSigMA: allosteric signaling and mutation analysis server","volume":"33","author":"Guarnera","year":"2017","journal-title":"Bioinformatics"},{"key":"2019062808124605600_B18","doi-asserted-by":"crossref","first-page":"11556","DOI":"10.1021\/ja504810z","article-title":"Systems biology brings new dimensions for structure-based drug design","volume":"136","author":"Pei","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"2019062808124605600_B19","doi-asserted-by":"crossref","first-page":"6607","DOI":"10.1021\/acs.chemrev.5b00542","article-title":"Ras conformational ensembles, allostery, and signaling","volume":"116","author":"Lu","year":"2016","journal-title":"Chem. Rev."},{"key":"2019062808124605600_B20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajhg.2016.09.020","article-title":"Proteome-scale investigation of protein allosteric regulation perturbed by somatic mutations in 7,000 cancer genomes","volume":"100","author":"Shen","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"2019062808124605600_B21","doi-asserted-by":"crossref","first-page":"D527","DOI":"10.1093\/nar\/gkv902","article-title":"ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks","volume":"44","author":"Shen","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B22","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.2764","article-title":"The Cancer Genome Atlas Pan-Cancer analysis project","volume":"45","author":"Weinstein","year":"2013","journal-title":"Nat. Genet."},{"key":"2019062808124605600_B23","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B24","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1093\/bioinformatics\/btt399","article-title":"Allosite: a method for predicting allosteric sites","volume":"29","author":"Huang","year":"2013","journal-title":"Bioinformatics"},{"key":"2019062808124605600_B25","doi-asserted-by":"crossref","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","article-title":"The Pfam protein families database: towards a more sustainable future","volume":"44","author":"Finn","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B26","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B27","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkw1074","article-title":"The ChEMBL database in 2017","volume":"45","author":"Gaulton","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B28","first-page":"1","article-title":"Imbalanced-learn: a Python toolbox to tackle the curse of imbalanced datasets in machine learning","volume":"18","author":"Lemaitre","year":"2017","journal-title":"J. Mach. Learn. Res."},{"key":"2019062808124605600_B29","first-page":"2825","article-title":"Scikit-learn: Machine learning in python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"2019062808124605600_B30","doi-asserted-by":"crossref","DOI":"10.1200\/PO.17.00011","article-title":"OncoKB: a precision oncology knowledge base","author":"Chakravarty","year":"2017","journal-title":"JCO Precis. Oncol."},{"key":"2019062808124605600_B31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng.3774","article-title":"CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer","volume":"49","author":"Griffith","year":"2017","journal-title":"Nat. Genet."},{"key":"2019062808124605600_B32","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/bib\/bbm064","article-title":"ROC analysis: applications to the classification of biological sequences and 3D structures","volume":"9","author":"Sonego","year":"2008","journal-title":"Brief. Bioinform."},{"key":"2019062808124605600_B33","doi-asserted-by":"crossref","first-page":"8816","DOI":"10.1158\/0008-5472.CAN-04-1923","article-title":"Activating mutations of the noonan syndrome-associated SHP2\/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia","volume":"64","author":"Bentires-Alj","year":"2004","journal-title":"Cancer Res."},{"key":"2019062808124605600_B34","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/carcin\/bgu025","article-title":"SHP2E76K mutant promotes lung tumorigenesis in transgenic mice","volume":"35","author":"Schneeberger","year":"2014","journal-title":"Carcinogenesis"},{"key":"2019062808124605600_B35","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int. J. Cancer."},{"key":"2019062808124605600_B36","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0140-6736(08)60728-X","article-title":"Head and neck cancer","volume":"371","author":"Argiris","year":"2008","journal-title":"Lancet."},{"key":"2019062808124605600_B37","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00432-013-1421-5","article-title":"Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer","volume":"139","author":"Sun","year":"2013","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"2019062808124605600_B38","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.drudis.2014.07.012","article-title":"Recent computational advances in the identification of allosteric sites in proteins","volume":"19","author":"Lu","year":"2014","journal-title":"Drug Discov. Today"},{"key":"2019062808124605600_B39","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/bioinformatics\/btu002","article-title":"PARS: a web server for the prediction of protein allosteric and regulatory sites","volume":"30","author":"Panjkovich","year":"2014","journal-title":"Bioinformatics"},{"key":"2019062808124605600_B40","doi-asserted-by":"crossref","first-page":"W249","DOI":"10.1093\/nar\/gkt284","article-title":"MCPath: Monte Carlo path generation approach to predict likely allosteric pathways and functional residues","volume":"41","author":"Kaya","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sbi.2017.10.002","article-title":"Structure-based prediction of protein allostery","volume":"50","author":"Greener","year":"2018","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2019062808124605600_B42","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gky374","article-title":"AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses","volume":"46","author":"Huang","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B43","doi-asserted-by":"crossref","first-page":"e1006228","DOI":"10.1371\/journal.pcbi.1006228","article-title":"Reversing allosteric communication: from detecting allosteric sites to inducing and tuning targeted allosteric response","volume":"14","author":"Tee","year":"2018","journal-title":"PLoS Comput. Biol."},{"key":"2019062808124605600_B44","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1021\/acs.chemrev.5b00631","article-title":"Emerging computational methods for the rational discovery of allosteric drugs","volume":"116","author":"Wagner","year":"2016","journal-title":"Chem. Rev."},{"key":"2019062808124605600_B45","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1093\/bioinformatics\/btv169","article-title":"ASBench: benchmarking sets for allosteric discovery","volume":"31","author":"Huang","year":"2015","journal-title":"Bioinformatics"},{"key":"2019062808124605600_B46","doi-asserted-by":"crossref","first-page":"W266","DOI":"10.1093\/nar\/gkt460","article-title":"SPACER: server for predicting allosteric communication and effects of regulation","volume":"41","author":"Goncearenco","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2019062808124605600_B47","article-title":"Allosteric modulator discovery: from serendipity to structure-based design","author":"Lu","year":"2019","journal-title":"J. Med. Chem."},{"key":"2019062808124605600_B48","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1021\/acs.accounts.8b00570","article-title":"Allosteric methods and their applications: facilitating the discovery of allosteric drugs and the investigation of allosteric mechanisms","volume":"52","author":"Lu","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"2019062808124605600_B49","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.cell.2014.10.051","article-title":"A glimpse of structural biology through X-ray crystallography","volume":"159","author":"Shi","year":"2014","journal-title":"Cell"},{"key":"2019062808124605600_B50","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11427-016-0034-1","article-title":"Genomic landscape of gastric cancer: molecular classification and potential targets","volume":"60","author":"Guo","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"2019062808124605600_B51","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/nsr\/nwx062","article-title":"The acidic tumor microenvironment: a target for smart cancer nano-theranostics","volume":"5","author":"Feng","year":"2018","journal-title":"Natl. Sci. Rev."},{"key":"2019062808124605600_B52","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwy124","article-title":"Phenotypes and targets-based chemical biology investigation in cancers","author":"Chen","year":"2018","journal-title":"Natl. Sci. Rev."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/advance-article-pdf\/doi\/10.1093\/nar\/gkz350\/28649978\/gkz350.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/47\/W1\/W315\/28879809\/gkz350.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T04:45:49Z","timestamp":1569041149000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/47\/W1\/W315\/5487263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":52,"journal-issue":{"issue":"W1","published-online":{"date-parts":[[2019,5,9]]},"published-print":{"date-parts":[[2019,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkz350","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7,2]]},"published":{"date-parts":[[2019,5,9]]}}}