{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:58:50Z","timestamp":1772845130086,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["CGL2017-89160P"],"award-info":[{"award-number":["CGL2017-89160P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"AGAUR","doi-asserted-by":"publisher","award":["2017SGR-1379"],"award-info":[{"award-number":["2017SGR-1379"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["FI-DGR2015"],"award-info":[{"award-number":["FI-DGR2015"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The McDonald and Kreitman test (MKT) is one of the most powerful and widely used methods to detect and quantify recurrent natural selection using DNA sequence data. Here we present iMKT (acronym for integrative McDonald and Kreitman test), a novel web-based service performing four distinct MKT types. It allows the detection and estimation of four different selection regimes \u2212adaptive, neutral, strongly deleterious and weakly deleterious\u2212 acting on any genomic sequence. iMKT can analyze both user's own population genomic data and pre-loaded Drosophila melanogaster and human sequences of protein-coding genes obtained from the largest population genomic datasets to date. Advanced options in the website allow testing complex hypotheses such as the application example showed here: do genes located in high recombination regions undergo higher rates of adaptation? We aim that iMKT will become a reference site tool for the study of evolutionary adaptation in massive population genomics datasets, especially in Drosophila and humans. iMKT is a free resource online at https:\/\/imkt.uab.cat.<\/jats:p>","DOI":"10.1093\/nar\/gkz372","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T11:12:22Z","timestamp":1556881942000},"page":"W283-W288","source":"Crossref","is-referenced-by-count":35,"title":["iMKT: the integrative McDonald and Kreitman test"],"prefix":"10.1093","volume":"47","author":[{"given":"Jes\u00fas","family":"Murga-Moreno","sequence":"first","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina and Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain"}]},{"given":"Marta","family":"Coronado-Zamora","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina and Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain"}]},{"given":"Sergi","family":"Hervas","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina and Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-0062","authenticated-orcid":false,"given":"S\u00f2nia","family":"Casillas","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina and Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-1475","authenticated-orcid":false,"given":"Antonio","family":"Barbadilla","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina and Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain"}]}],"member":"286","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"2020071623533246500_B1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1534\/genetics.116.196493","article-title":"Molecular population genetics","volume":"205","author":"Casillas","year":"2017","journal-title":"Genetics"},{"key":"2020071623533246500_B2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/351652a0","article-title":"Adaptive protein evolution at the Adh locus in drosophila","volume":"351","author":"McDonald","year":"1991","journal-title":"Nature"},{"key":"2020071623533246500_B3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/267275a0","article-title":"Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution","volume":"267","author":"Kimura","year":"1977","journal-title":"Nature"},{"key":"2020071623533246500_B4","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/217624a0","article-title":"Evolutionary rate at the molecular level","volume":"217","author":"Kimura","year":"1968","journal-title":"Nature"},{"key":"2020071623533246500_B5","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511623486","volume-title":"The Neutral Theory of Molecular Evolution","author":"Kimura","year":"1983"},{"key":"2020071623533246500_B6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1017\/S0016672300032365","article-title":"The effect of background selection against deleterious mutations on weakly selected, linked variants","volume":"63","author":"Charlesworth","year":"1994","journal-title":"Genet. 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