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A crucial aspect to enable such repurposing is that the drug's binding site on the original target is similar to that on the alternative target. Based on the assumption that proteins with similar binding sites may bind to similar drugs, the 3D substructure similarity data can be used to identify similar sites in other proteins that are not known targets. The Drug ReposER (DRug REPOSitioning Exploration Resource) web server is designed to identify potential targets for drug repurposing based on sub-structural similarity to the binding interfaces of known drug binding sites. The application has pre-computed amino acid arrangements from protein structures in the Protein Data Bank that are similar to the 3D arrangements of known drug binding sites thus allowing users to explore them as alternative targets. Users can annotate new structures for sites that are similarly arranged to the residues found in known drug binding interfaces. The search results are presented as mappings of matched sidechain superpositions. The results of the searches can be visualized using an integrated NGL viewer. The Drug ReposER server has no access restrictions and is available at http:\/\/mfrlab.org\/drugreposer\/.<\/jats:p>","DOI":"10.1093\/nar\/gkz391","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T11:26:10Z","timestamp":1556796370000},"page":"W350-W356","source":"Crossref","is-referenced-by-count":26,"title":["Drug ReposER: a web server for predicting similar amino acid arrangements to known drug binding interfaces for potential drug repositioning"],"prefix":"10.1093","volume":"47","author":[{"given":"Nur Syatila","family":"Ab\u00a0Ghani","sequence":"first","affiliation":[{"name":"Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor\u00a043600, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Effirul Ikhwan","family":"Ramlan","sequence":"additional","affiliation":[{"name":"School of Computing, Engineering and Intelligent Systems, Ulster University, Northlands Road, Magee Campus, Londonderry BT48 7JL, UK"},{"name":"Malaysia Genome Institute, National Institutes of Biotechnology Malaysia, Jalan Bangi, 43000 Kajang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4275-4663","authenticated-orcid":false,"given":"Mohd","family":"Firdaus-Raih","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor\u00a043600, Malaysia"},{"name":"Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor\u00a043600, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"2019062808223569200_B1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/534314a","article-title":"Can you teach old drugs new tricks","volume":"534","author":"Nosengo","year":"2016","journal-title":"Nature"},{"key":"2019062808223569200_B2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40360-017-0128-7","article-title":"Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects","volume":"18","author":"Chartier","year":"2017","journal-title":"BMC Pharmacol. 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