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In homology modeling, this leads to larger deviations from the homologous templates, and loop modeling of homology models remains an open problem. To address this issue, we have previously developed the DaReUS-Loop protocol, leading to significant improvement over existing methods. Here, a DaReUS-Loop web server is presented, providing an automated platform for modeling or remodeling loops in the context of homology models. This is the first web server accepting a protein with up to 20 loop regions, and modeling them all in parallel. It also provides a prediction confidence level that corresponds to the expected accuracy of the loops. DaReUS-Loop facilitates the analysis of the results through its interactive graphical interface and is freely available at http:\/\/bioserv.rpbs.univ-paris-diderot.fr\/services\/DaReUS-Loop\/.<\/jats:p>","DOI":"10.1093\/nar\/gkz403","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T19:34:38Z","timestamp":1557257678000},"page":"W423-W428","source":"Crossref","is-referenced-by-count":43,"title":["DaReUS-Loop: a web server to model multiple loops in homology models"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8413-2665","authenticated-orcid":false,"given":"Yasaman","family":"Karami","sequence":"first","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Diderot, CNRS UMR 8251, INSERM ERL U1133, Paris, France"},{"name":"Ressource Parisienne en Bioinformatique Structurale (RPBS), Paris, France"}]},{"given":"Julien","family":"Rey","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Diderot, CNRS UMR 8251, INSERM ERL U1133, Paris, France"},{"name":"Ressource Parisienne en Bioinformatique Structurale (RPBS), Paris, France"}]},{"given":"Guillaume","family":"Postic","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Diderot, CNRS UMR 8251, INSERM ERL U1133, Paris, France"},{"name":"Ressource Parisienne en Bioinformatique Structurale (RPBS), Paris, France"},{"name":"Institut Fran\u00e7ais de Bioinformatique (IFB), UMS 3601-CNRS, Universit\u00e9 Paris-Saclay, Orsay, France"}]},{"given":"Samuel","family":"Murail","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Diderot, CNRS UMR 8251, INSERM ERL U1133, Paris, France"}]},{"given":"Pierre","family":"Tuff\u00e9ry","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Diderot, CNRS UMR 8251, INSERM ERL U1133, Paris, France"},{"name":"Ressource Parisienne en Bioinformatique Structurale (RPBS), Paris, France"}]},{"given":"Sjoerd J","family":"de\u00a0Vries","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Diderot, CNRS UMR 8251, INSERM ERL U1133, Paris, France"},{"name":"Ressource Parisienne en Bioinformatique Structurale (RPBS), Paris, France"}]}],"member":"286","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"2019062808224440900_B1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.309.5731.75","article-title":"What don\u2019t we know","volume":"309","author":"Kennedy","year":"2005","journal-title":"Science"},{"key":"2019062808224440900_B2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2019062808224440900_B3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.biophys.29.1.291","article-title":"Comparative protein structure modeling of genes and genomes","volume":"29","author":"Marti-Renom","year":"2000","journal-title":"Annu. 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