{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:26:22Z","timestamp":1740129982110,"version":"3.37.3"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["279408"],"award-info":[{"award-number":["279408"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P 30550","P 30680-B21"],"award-info":[{"award-number":["P 30550","P 30680-B21"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The structure, dynamics and, ultimately, biological function of proteins and nucleic acids are determined by the physicochemical properties of their primary sequences. Such properties are frequently captured via one-dimensional profile plots depicting a given physicochemical variable as a function of sequence position. Hydrophobicity, charge or structural disorder in proteins or nucleobase-density in nucleic acids are routinely visualized in this manner to analyze sequences at a glance. Such visualizations, however, are typically created case-by-case in a purely static manner, employ fixed visualization parameters only and do not enable a quantitative comparison between different sequences. Here, we present VOLPES (volpes.univie.ac.at), a user-friendly web server and the corresponding JavaScript library that enable a fully interactive, multifunctional visualization, analysis and comparison of the physicochemical properties of protein and nucleic-acid sequences, allowing unprecedented insight into biological sequence data and creating a starting point for further in-depth exploration.<\/jats:p>","DOI":"10.1093\/nar\/gkz407","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T15:13:13Z","timestamp":1556809993000},"page":"W632-W635","source":"Crossref","is-referenced-by-count":14,"title":["VOLPES: an interactive web-based tool for visualizing and comparing physicochemical properties of biological sequences"],"prefix":"10.1093","volume":"47","author":[{"given":"Lukas","family":"Bartonek","sequence":"first","affiliation":[{"name":"Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Campus Vienna Biocenter 5, 1030 Vienna, Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-3675","authenticated-orcid":false,"given":"Bojan","family":"Zagrovic","sequence":"additional","affiliation":[{"name":"Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Campus Vienna Biocenter 5, 1030 Vienna, Austria"}]}],"member":"286","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"2019062808230904600_B1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/protein\/gzi032","article-title":"Transmembrane helix prediction: a comparative evaluation and analysis","volume":"18","author":"Cuthbertson","year":"2005","journal-title":"Protein Eng. 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