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For sets of protein-coding genes, ontology and pathway analyses are powerful tools for generating new insights from statistical enrichment of gene features. Here we present the LnCompare web server, an equivalent resource for studying the properties of lncRNA gene sets. The Gene Set Feature Comparison mode tests for enrichment amongst a panel of quantitative and categorical features, spanning gene structure, evolutionary conservation, expression, subcellular localization, repetitive sequences and disease association. Moreover, in Similar Gene Identification mode, users may identify other lncRNAs by similarity across a defined range of features. Comprehensive results may be downloaded in tabular and graphical formats, in addition to the entire feature resource. LnCompare will empower researchers to extract useful hypotheses and candidates from lncRNA gene sets.<\/jats:p>","DOI":"10.1093\/nar\/gkz410","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T16:33:40Z","timestamp":1557160420000},"page":"W523-W529","source":"Crossref","is-referenced-by-count":22,"title":["LnCompare: gene set feature analysis for human long non-coding RNAs"],"prefix":"10.1093","volume":"47","author":[{"given":"Joana","family":"Carlevaro-Fita","sequence":"first","affiliation":[{"name":"Department of BioMedical Research (DBMR), University of Bern, Bern 3008, Switzerland"},{"name":"Department of Medical Oncology, Inselspital, University Hospital and University of Bern 3010, Switzerland"}]},{"given":"Leibo","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China"}]},{"given":"Shan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"}]},{"given":"Panagiotis","family":"Chouvardas","sequence":"additional","affiliation":[{"name":"Department of BioMedical Research (DBMR), University of Bern, Bern 3008, Switzerland"},{"name":"Department of Medical Oncology, Inselspital, University Hospital and University of Bern 3010, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-2782","authenticated-orcid":false,"given":"Rory","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of BioMedical Research (DBMR), University of Bern, Bern 3008, Switzerland"},{"name":"Department of Medical Oncology, Inselspital, University Hospital and University of Bern 3010, Switzerland"}]},{"given":"Jianwei","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"}]}],"member":"286","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"2019062808225780000_B1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13059-017-1348-2","article-title":"The multidimensional mechanisms of long noncoding RNA function","volume":"18","author":"Marchese","year":"2017","journal-title":"Genome Biol."},{"key":"2019062808225780000_B2","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Res."},{"key":"2019062808225780000_B3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1073\/pnas.0706729105","article-title":"Specific expression of long noncoding RNAs in the mouse brain","volume":"105","author":"Mercer","year":"2008","journal-title":"Proc. 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