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To overcome this issue, it has been shown that coarse-grained approaches, although requiring less computational power, are still capable of correctly describing molecular events underlying big conformational changes in biological systems. Here, we present the Martini coarse-grained membrane protein dynamics (MERMAID), a publicly available web interface that allows the user to prepare and run coarse-grained molecular dynamics (CGMD) simulations and to analyse the trajectories.<\/jats:p>","DOI":"10.1093\/nar\/gkz416","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T11:33:52Z","timestamp":1557142432000},"page":"W456-W461","source":"Crossref","is-referenced-by-count":19,"title":["MERMAID: dedicated web server to prepare and run coarse-grained membrane protein dynamics"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4371-3815","authenticated-orcid":false,"given":"Mangesh","family":"Damre","sequence":"first","affiliation":[{"name":"Neurobiology, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy"},{"name":"Department of Biotechnology, University of Verona, Ca Vignal 1, strada Le Grazie, 15, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Marchetto","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Verona, Ca Vignal 1, strada Le Grazie, 15, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Giorgetti","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Verona, Ca Vignal 1, strada Le Grazie, 15, 37134 Verona, Italy"},{"name":"Institute for Advanced Simulations (IAS)-5\/Institute for Neuroscience and Medicine (INM)-9, Forschungszentrum J\u00fclich, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"2019062808323326900_B1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"2019062808323326900_B2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.bbamem.2017.10.033","article-title":"Conformational landscapes of membrane proteins delineated by enhanced sampling molecular dynamics simulations","volume":"1860","author":"Harpole","year":"2018","journal-title":"Biochim. 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