{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:19:59Z","timestamp":1774689599415,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Padova University","award":["SID-2017"],"award-info":[{"award-number":["SID-2017"]}]},{"DOI":"10.13039\/501100003407","name":"Ministry of Education, Universities and Research","doi-asserted-by":"publisher","award":["D15D18000410001"],"award-info":[{"award-number":["D15D18000410001"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>As the amount of genomic variation data increases, tools that are able to score the functional impact of single nucleotide variants become more and more necessary. While there are several prediction servers available for interpreting the effects of variants in the human genome, only few have been developed for other species, and none were specifically designed for species of veterinary interest such as the dog. Here, we present Fido-SNP the first predictor able to discriminate between Pathogenic and Benign single-nucleotide variants in the dog genome. Fido-SNP is a binary classifier based on the Gradient Boosting algorithm. It is able to classify and score the impact of variants in both coding and non-coding regions based on sequence features within seconds. When validated on a previously unseen set of annotated variants from the OMIA database, Fido-SNP reaches 88% overall accuracy, 0.77 Matthews correlation coefficient and 0.91 Area Under the ROC Curve.<\/jats:p>","DOI":"10.1093\/nar\/gkz420","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T18:36:42Z","timestamp":1557254202000},"page":"W136-W141","source":"Crossref","is-referenced-by-count":10,"title":["Fido-SNP: the first webserver for scoring the impact of single nucleotide variants in the dog genome"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-0963","authenticated-orcid":false,"given":"Emidio","family":"Capriotti","sequence":"first","affiliation":[{"name":"BioFolD Unit, Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via F. Selmi 3, 40126 Bologna, Italy"}]},{"given":"Ludovica","family":"Montanucci","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Food Science. University of Padova, Viale dell\u2019Universit\u00e0, 16, 35020 Legnaro (Padova), Italy"}]},{"given":"Giuseppe","family":"Profiti","sequence":"additional","affiliation":[{"name":"BioDec srl. Via Calzavecchio 20, 40033 Casalecchio di Reno (Bologna), Italy"}]},{"given":"Ivan","family":"Rossi","sequence":"additional","affiliation":[{"name":"BioDec srl. Via Calzavecchio 20, 40033 Casalecchio di Reno (Bologna), Italy"}]},{"given":"Diana","family":"Giannuzzi","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Food Science. University of Padova, Viale dell\u2019Universit\u00e0, 16, 35020 Legnaro (Padova), Italy"}]},{"given":"Luca","family":"Aresu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Torino, Largo P. Braccini 2, 10095 Grugliasco, (Torino), Italy"}]},{"given":"Piero","family":"Fariselli","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Food Science. University of Padova, Viale dell\u2019Universit\u00e0, 16, 35020 Legnaro (Padova), Italy"},{"name":"Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy"}]}],"member":"286","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"2019062808325234700_B1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1093\/bioinformatics\/btr295","article-title":"Bioinformatics challenges for personalized medicine","volume":"27","author":"Fernald","year":"2011","journal-title":"Bioinformatics"},{"key":"2019062808325234700_B2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/humu.22987","article-title":"Variation interpretation predictors: principles, types, performance, and choice","volume":"37","author":"Niroula","year":"2016","journal-title":"Hum. 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