{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T21:56:12Z","timestamp":1784066172569,"version":"3.55.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies R&D Program","doi-asserted-by":"publisher","award":["2016YFC0900100"],"award-info":[{"award-number":["2016YFC0900100"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573022"],"award-info":[{"award-number":["81573022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31530036"],"award-info":[{"award-number":["31530036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91742203"],"award-info":[{"award-number":["91742203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduced in 2017, the GEPIA (Gene Expression Profiling Interactive Analysis) web server has been a valuable and highly cited resource for gene expression analysis based on tumor and normal samples from the TCGA and the GTEx databases. Here, we present GEPIA2, an updated and enhanced version to provide insights with higher resolution and more functionalities. Featuring 198\u00a0619 isoforms and 84 cancer subtypes, GEPIA2 has extended gene expression quantification from the gene level to the transcript level, and supports analysis of a specific cancer subtype, and comparison between subtypes. In addition, GEPIA2 has adopted new analysis techniques of gene signature quantification inspired by single-cell sequencing studies, and provides customized analysis where users can upload their own RNA-seq data and compare them with TCGA and GTEx samples. We also offer an API for batch process and easy retrieval of the analysis results. The updated web server is publicly accessible at http:\/\/gepia2.cancer-pku.cn\/.<\/jats:p>","DOI":"10.1093\/nar\/gkz430","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T07:31:37Z","timestamp":1557473497000},"page":"W556-W560","source":"Crossref","is-referenced-by-count":4281,"title":["GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis"],"prefix":"10.1093","volume":"47","author":[{"given":"Zefang","family":"Tang","sequence":"first","affiliation":[{"name":"School of Life Sciences and BIOPIC, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxi","family":"Kang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and BIOPIC, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Li","sequence":"additional","affiliation":[{"name":"Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences and BIOPIC, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and BIOPIC, Peking University, Beijing 100871, China"},{"name":"Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China"},{"name":"Beijing Advanced Innovation Center for Genomics, Peking University, Beijing\u00a0100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"2019062808324242400_B1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"Human genomics. 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