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At the heart of the package is identifying and visualizing differences between conformations at the secondary structure and at the residue level, such as contact differences or side chain conformational differences found between two protein chains. The protein secondary structures are determined according to four established methods (DSSP, STRIDE, P-SEA and STICKS), and as each employs different assignment strategies, small conformational differences between the two structures can give rise to paired residues being denoted as having different secondary structure features with the different methods. 2StrucCompare captures both the large and more subtle differences found between structures, enabling visualization of these differences that could be key to an understanding of a proteins\u2019 function.<\/jats:p>\n               <jats:p>2StrucCompare is freely accessible at http:\/\/2struccompare.cryst.bbk.ac.uk\/index.php<\/jats:p>","DOI":"10.1093\/nar\/gkz456","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T15:14:47Z","timestamp":1558106087000},"page":"W477-W481","source":"Crossref","is-referenced-by-count":26,"title":["2StrucCompare: a webserver for visualizing small but noteworthy differences between protein tertiary structures through interrogation of the secondary structure content"],"prefix":"10.1093","volume":"47","author":[{"given":"Elliot D","family":"Drew","sequence":"first","affiliation":[{"name":"School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W","family":"Janes","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"2019062808325631600_B1","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1093\/bioinformatics\/btq572","article-title":"Pre-calculated protein structure alignments at the RCSB PDB website","volume":"26","author":"Prli\u0107","year":"2010","journal-title":"Bioinformatics"},{"key":"2019062808325631600_B2","doi-asserted-by":"crossref","first-page":"W351","DOI":"10.1093\/nar\/gkw357","article-title":"Dali server update","volume":"44","author":"Holm","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2019062808325631600_B3","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1093\/nar\/gki524","article-title":"TM-align: a protein structure alignment algorithm based on TM-score","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2019062808325631600_B4","doi-asserted-by":"crossref","first-page":"W590","DOI":"10.1093\/nar\/gkh477","article-title":"SuperPose: a simple server for sophisticated structural superposition","volume":"32","author":"Maiti","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2019062808325631600_B5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0959-440X(96)80058-3","article-title":"Surprising similarities in structure comparison","volume":"6","author":"Gibrat","year":"1996","journal-title":"Curr. 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