{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:17:57Z","timestamp":1769005077884,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Huazhong Agricultural University Scientific & Technological Self-innovation Foundation","award":["11041810351"],"award-info":[{"award-number":["11041810351"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Numerous studies indicate that non-coding RNAs (ncRNAs) have critical functions across biological processes, and single-nucleotide polymorphisms (SNPs) could contribute to diseases or traits through influencing ncRNA expression. However, the associations between SNPs and ncRNA expression are largely unknown. Therefore, genome-wide expression quantitative trait loci (eQTL) analysis to assess the effects of SNPs on ncRNA expression, especially in multiple cancer types, will help to understand how risk alleles contribute toward tumorigenesis and cancer development. Using genotype data and expression profiles of ncRNAs of &amp;gt;8700 samples from The Cancer Genome Atlas (TCGA), we developed a computational pipeline to systematically identify ncRNA-related eQTLs (ncRNA-eQTLs) across 33 cancer types. We identified a total of 6\u00a0133\u00a0278 and 721\u00a0122 eQTL-ncRNA pairs in cis-eQTL and trans-eQTL analyses, respectively. Further survival analyses identified 8312 eQTLs associated with patient survival times. Furthermore, we linked ncRNA-eQTLs to genome-wide association study (GWAS) data and found 262\u00a0332 ncRNA-eQTLs overlapping with known disease- and trait-associated loci. Finally, a user-friendly database, ncRNA-eQTL (http:\/\/ibi.hzau.edu.cn\/ncRNA-eQTL), was developed for free searching, browsing and downloading of all ncRNA-eQTLs. We anticipate that such an integrative and comprehensive resource will improve our understanding of the mechanistic basis of human complex phenotypic variation, especially for ncRNA- and cancer-related studies.<\/jats:p>","DOI":"10.1093\/nar\/gkz711","type":"journal-article","created":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T11:12:38Z","timestamp":1564830758000},"page":"D956-D963","source":"Crossref","is-referenced-by-count":56,"title":["ncRNA-eQTL: a database to systematically evaluate the effects of SNPs on non-coding RNA expression across cancer types"],"prefix":"10.1093","volume":"48","author":[{"given":"Jiang","family":"Li","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawen","family":"Xue","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Talal","family":"Amin","sequence":"additional","affiliation":[{"name":"National Institute of Genomics and Advanced Biotechnology, National Agriculture Research Center, Islamabad 44051, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbo","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqian","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Niu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Gong","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China"},{"name":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"key":"2020010521381154200_B1","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.7754\/Clin.Lab.2015.150312","article-title":"High expression of IncRNA-PCNA-AS1 in human gastric cancer and its clinical significances","volume":"61","author":"Dang","year":"2015","journal-title":"Clin. 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