{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:00:16Z","timestamp":1768402816649,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ipsen Bioinnovation Ltd."},{"DOI":"10.13039\/100012698","name":"Jack Brockhoff Foundation","doi-asserted-by":"publisher","award":["JBF 4186"],"award-info":[{"award-number":["JBF 4186"]}],"id":[{"id":"10.13039\/100012698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1072476"],"award-info":[{"award-number":["APP1072476"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000292","name":"Cystic Fibrosis Trust","doi-asserted-by":"publisher","award":["SRC 010 - RG92232"],"award-info":[{"award-number":["SRC 010 - RG92232"]}],"id":[{"id":"10.13039\/501100000292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M026302\/1"],"award-info":[{"award-number":["MR\/M026302\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["093167MA"],"award-info":[{"award-number":["093167MA"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["200814\/Z\/16\/Z"],"award-info":[{"award-number":["200814\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ipsen Bioinnovation Ltd., Cambridge Studentship","award":["08032016"],"award-info":[{"award-number":["08032016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Carbohydrate-binding proteins play crucial roles across all organisms and viruses. The complexity of carbohydrate structures, together with inconsistencies in how their 3D structures are reported, has led to difficulties in characterizing the protein\u2013carbohydrate interfaces. In order to better understand protein\u2013carbohydrate interactions, we have developed an open-access database, ProCarbDB, which, unlike the Protein Data Bank (PDB), clearly distinguishes between the complete carbohydrate ligands and their monomeric units. ProCarbDB is a comprehensive database containing over 5200 3D X-ray crystal structures of protein\u2013carbohydrate complexes. In ProCarbDB, the complete carbohydrate ligands are annotated and all their interactions are displayed. Users can also select any protein residue in the proximity of the ligand to inspect its interactions with the carbohydrate ligand and with other neighbouring protein residues. Where available, additional curated information on the binding affinity of the complex and the effects of mutations on the binding have also been provided in the database. We believe that ProCarbDB will be an invaluable resource for understanding protein\u2013carbohydrate interfaces. The ProCarbDB web server is freely available at http:\/\/www.procarbdb.science\/procarb.<\/jats:p>","DOI":"10.1093\/nar\/gkz860","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T04:17:03Z","timestamp":1570508223000},"page":"D368-D375","source":"Crossref","is-referenced-by-count":28,"title":["ProCarbDB: a database of carbohydrate-binding proteins"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9329-114X","authenticated-orcid":false,"given":"Liviu","family":"Copoiu","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK"}]},{"given":"Pedro H M","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-2413","authenticated-orcid":false,"given":"David B","family":"Ascher","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK"},{"name":"Department of Biochemistry, University of Melbourne, Flemington Road, Parkville, Australia"}]},{"given":"Tom L","family":"Blundell","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK"}]},{"given":"Sony","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK"}]}],"member":"286","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"2020010521384202000_B1","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1039\/b414350g","article-title":"Lectins: tools for the molecular understanding of the glycocode","volume":"3","author":"Ambrosi","year":"2005","journal-title":"Org. 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