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PathBank aims to provide a pathway for every protein and a map for every metabolite. This resource is designed specifically to support pathway elucidation and pathway discovery in transcriptomics, proteomics, metabolomics and systems biology. It provides detailed, fully searchable, hyperlinked diagrams of metabolic, metabolite signaling, protein signaling, disease, drug and physiological pathways. All PathBank pathways include information on the relevant organs, organelles, subcellular compartments, cofactors, molecular locations, chemical structures and protein quaternary structures. Each small molecule is hyperlinked to the rich data contained in public chemical databases such as HMDB or DrugBank and each protein or enzyme complex is hyperlinked to UniProt. All PathBank pathways are accompanied with references and detailed descriptions which provide an overview of the pathway, condition or processes depicted in each diagram. Every PathBank pathway is downloadable in several machine-readable and image formats including BioPAX, SBML, PWML, SBGN, RXN, PNG and SVG. PathBank also supports community annotations and submissions through the web-based PathWhiz pathway illustrator. The vast majority of PathBank's pathways (&amp;gt;95%) are not found in any other public pathway database.<\/jats:p>","DOI":"10.1093\/nar\/gkz861","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T15:30:26Z","timestamp":1570548626000},"page":"D470-D478","source":"Crossref","is-referenced-by-count":130,"title":["PathBank: a comprehensive pathway database for model organisms"],"prefix":"10.1093","volume":"48","author":[{"given":"David S","family":"Wishart","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"},{"name":"Department of Computing Science, University of Alberta, Edmonton, AB\u00a0T6G 2E8, Canada"}]},{"given":"Carin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Ana","family":"Marcu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Hasan","family":"Badran","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Allison","family":"Pon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Zachary","family":"Budinski","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Jonas","family":"Patron","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Debra","family":"Lipton","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Xuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Eponine","family":"Oler","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Krissa","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Ma\u00eflys","family":"Paccoud","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Chelsea","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"An C","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Christopher","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"William","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB\u00a0T6G 2E9, Canada"}]},{"given":"Miguel","family":"Ramirez-Gaona","sequence":"additional","affiliation":[{"name":"Department of Plant Breeding, Wageningen University and Research, 6708 PB Wageningen, Gelderland, Netherlands"}]}],"member":"286","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"2020010521381189500_B1","doi-asserted-by":"crossref","first-page":"D293","DOI":"10.1093\/nar\/gkh108","article-title":"The CyberCell Database (CCDB): a comprehensive, self-updating, relational database to coordinate and facilitate in silico modeling of Escherichia coli","volume":"32","author":"Sundararaj","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2020010521381189500_B2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nbt.1614","article-title":"What is flux balance analysis","volume":"28","author":"Orth","year":"2010","journal-title":"Nat. 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