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VDJbase is designed to act as a resource that will allow the scientific community to explore the genetic variability of the immunoglobulin (Ig) and T cell receptor (TR) gene loci. It can also assist in the investigation of Ig- and TR-related genetic predispositions to diseases. Our database includes web-based query and online tools to assist in visualization and analysis of the genotype and haplotype data. It enables users to detect those alleles and genes that are significantly over-represented in a particular population, in terms of genotype, haplotype and gene expression. The database website can be freely accessed at https:\/\/www.vdjbase.org\/, and no login is required. The data and code use creative common licenses and are freely downloadable from https:\/\/bitbucket.org\/account\/user\/yaarilab\/projects\/GPHP.<\/jats:p>","DOI":"10.1093\/nar\/gkz872","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T15:26:54Z","timestamp":1569943614000},"page":"D1051-D1056","source":"Crossref","is-referenced-by-count":64,"title":["VDJbase: an adaptive immune receptor genotype and haplotype database"],"prefix":"10.1093","volume":"48","author":[{"given":"Aviv","family":"Omer","sequence":"first","affiliation":[{"name":"Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan\u00a05290002, Israel"}]},{"given":"Or","family":"Shemesh","sequence":"additional","affiliation":[{"name":"Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan\u00a05290002, Israel"}]},{"given":"Ayelet","family":"Peres","sequence":"additional","affiliation":[{"name":"Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan\u00a05290002, Israel"}]},{"given":"Pazit","family":"Polak","sequence":"additional","affiliation":[{"name":"Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan\u00a05290002, Israel"}]},{"given":"Adrian J","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Institute of Structural and Molecular Biology, Birkbeck, University of London, London, UK"}]},{"given":"Corey\u00a0T","family":"Watson","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine, Biochemistry and Molecular Genetics, Louisville, KY\u00a040292, USA"}]},{"given":"Scott D","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA 94305, USA"}]},{"given":"Andrew M","family":"Collins","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences, University of NSW, Kensington, Sydney, NSW\u00a02052, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-6840","authenticated-orcid":false,"given":"William","family":"Lees","sequence":"additional","affiliation":[{"name":"Institute of Structural and Molecular Biology, Birkbeck, University of London, London, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9311-9884","authenticated-orcid":false,"given":"Gur","family":"Yaari","sequence":"additional","affiliation":[{"name":"Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan\u00a05290002, Israel"}]}],"member":"286","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"2020010521383990200_B1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nbt.2782","article-title":"The promise and challenge of high-throughput sequencing of the antibody repertoire","volume":"32","author":"Georgiou","year":"2014","journal-title":"Nat. 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