{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:11:23Z","timestamp":1777407083803,"version":"3.51.4"},"reference-count":14,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Netherlands Organization for Scientific Research","award":["863.15.002"],"award-info":[{"award-number":["863.15.002"]}]},{"DOI":"10.13039\/100008367","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE-1652424"],"award-info":[{"award-number":["CHE-1652424"]}],"id":[{"id":"10.13039\/100008367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NSF GRF","award":["00039202"],"award-info":[{"award-number":["00039202"]}]},{"name":"Graduate School for Experimental Plant Sciences"},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF10CC1016517"],"award-info":[{"award-number":["NNF10CC1016517"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF16OC0021746"],"award-info":[{"award-number":["NNF16OC0021746"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013407","name":"Netherlands eScience Center","doi-asserted-by":"publisher","award":["ASDI.2017.030"],"award-info":[{"award-number":["ASDI.2017.030"]}],"id":[{"id":"10.13039\/100013407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U41-AT008718"],"award-info":[{"award-number":["U41-AT008718"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fueled by the explosion of (meta)genomic data, genome mining of specialized metabolites has become a major technology for drug discovery and studying microbiome ecology. In these efforts, computational tools like antiSMASH have played a central role through the analysis of Biosynthetic Gene Clusters (BGCs). Thousands of candidate BGCs from microbial genomes have been identified and stored in public databases. Interpreting the function and novelty of these predicted BGCs requires comparison with a well-documented set of BGCs of known function. The MIBiG (Minimum Information about a Biosynthetic Gene Cluster) Data Standard and Repository was established in 2015 to enable curation and storage of known BGCs. Here, we present MIBiG 2.0, which encompasses major updates to the schema, the data, and the online repository itself. Over the past five years, 851 new BGCs have been added. Additionally, we performed extensive manual data curation of all entries to improve the annotation quality of our repository. We also redesigned the data schema to ensure the compliance of future annotations. Finally, we improved the user experience by adding new features such as query searches and a statistics page, and enabled direct link-outs to chemical structure databases. The repository is accessible online at https:\/\/mibig.secondarymetabolites.org\/.<\/jats:p>","DOI":"10.1093\/nar\/gkz882","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T19:26:54Z","timestamp":1569958014000},"source":"Crossref","is-referenced-by-count":241,"title":["MIBiG 2.0: a repository for biosynthetic gene clusters of known function"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-511X","authenticated-orcid":false,"given":"Satria A","family":"Kautsar","sequence":"first","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen, NL, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-6051","authenticated-orcid":false,"given":"Kai","family":"Blin","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, DK, the Netherlands"}]},{"given":"Simon","family":"Shaw","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, DK, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-1607","authenticated-orcid":false,"given":"Jorge C","family":"Navarro-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Fungal Natural Products Group, Westerdijk Fungal Biodiversity Institute, Utrecht, NL, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-6718","authenticated-orcid":false,"given":"Barbara R","family":"Terlouw","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen, NL, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-5511","authenticated-orcid":false,"given":"Justin J J","family":"van\u00a0der\u00a0Hooft","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen, NL, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-804X","authenticated-orcid":false,"given":"Jeffrey A","family":"van\u00a0Santen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Simon Fraser University, Burnaby, CA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7244-567X","authenticated-orcid":false,"given":"Vittorio","family":"Tracanna","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen, NL, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9125-9912","authenticated-orcid":false,"given":"Hernando G","family":"Suarez\u00a0Duran","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen, NL, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9609-9401","authenticated-orcid":false,"given":"Vict\u00f2ria","family":"Pascal\u00a0Andreu","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen, NL, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-3862","authenticated-orcid":false,"given":"Nelly","family":"Selem-Mojica","sequence":"additional","affiliation":[{"name":"Evolution of Metabolic Diversity Laboratory, Langebio, Cinvestav-IPN, Irapuato, MX, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8420-1325","authenticated-orcid":false,"given":"Mohammad","family":"Alanjary","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen, NL, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6947-7913","authenticated-orcid":false,"given":"Serina L","family":"Robinson","sequence":"additional","affiliation":[{"name":"BioTechnology Institute, University of Minnesota-Twin Cities, MN, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-3461","authenticated-orcid":false,"given":"George","family":"Lund","sequence":"additional","affiliation":[{"name":"Biointeractions and Crop Protection, Rothamsted Research, Harpenden, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-7926","authenticated-orcid":false,"given":"Samuel C","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Haverford College, Haverford, PA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1286-0609","authenticated-orcid":false,"given":"Ashley C","family":"Sisto","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Haverford College, Haverford, PA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4342-2815","authenticated-orcid":false,"given":"Louise K","family":"Charkoudian","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Haverford College, Haverford, PA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8152-6642","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Collemare","sequence":"additional","affiliation":[{"name":"Fungal Natural Products Group, Westerdijk Fungal Biodiversity Institute, Utrecht, NL, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-4971","authenticated-orcid":false,"given":"Roger G","family":"Linington","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Simon Fraser University, Burnaby, CA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-5120","authenticated-orcid":false,"given":"Tilmann","family":"Weber","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, DK, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-2821","authenticated-orcid":false,"given":"Marnix H","family":"Medema","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen, NL, the Netherlands"}]}],"member":"286","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"2019101504385452600_B1","doi-asserted-by":"crossref","first-page":"W81","DOI":"10.1093\/nar\/gkz310","article-title":"antiSMASH 5.0: 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