{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:54:02Z","timestamp":1770227642825,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty of Medicine and Health Sciences of the Universit\u00e9 de Sherbrooke"},{"name":"Canada Research Chair in RNA Biology and Cancer Genomics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Small nucleolar RNAs (snoRNAs) are an abundant type of non-coding RNA with conserved functions in all known eukaryotes. Classified into two main families, the box C\/D and H\/ACA snoRNAs, they enact their most well characterized role of guiding site specific modifications in ribosomal RNA, through the formation of specific ribonucleoprotein complexes, with fundamental implications in ribosome biogenesis. However, it is becoming increasingly clear that the landscape of snoRNA cellular functionality is much broader than it once seemed with novel members, non-uniform expression patterns, new and diverse targets as well as several emerging non-canonical functions ranging from the modulation of alternative splicing to the regulation of chromatin architecture. In order to facilitate the further characterization of human snoRNAs in a holistic manner, we introduce an online interactive database tool: snoDB. Its purpose is to consolidate information on human snoRNAs from different sources such as sequence databases, target information, both canonical and non-canonical from the literature and from high-throughput RNA\u2013RNA interaction datasets, as well as high-throughput sequencing data that can be visualized interactively.<\/jats:p>","DOI":"10.1093\/nar\/gkz884","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T19:26:54Z","timestamp":1569958014000},"page":"D220-D225","source":"Crossref","is-referenced-by-count":104,"title":["snoDB: an interactive database of human snoRNA sequences, abundance and interactions"],"prefix":"10.1093","volume":"48","author":[{"given":"Philia","family":"Bouchard-Bourelle","sequence":"first","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}]},{"given":"Cl\u00e9ment","family":"Desjardins-Henri","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}]},{"given":"Darren","family":"Mathurin-St-Pierre","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}]},{"given":"Gabrielle","family":"Deschamps-Francoeur","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}]},{"given":"\u00c9tienne","family":"Fafard-Couture","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}]},{"given":"Jean-Michel","family":"Garant","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}]},{"given":"Sherif Abou","family":"Elela","sequence":"additional","affiliation":[{"name":"D\u00e9partement de microbiologie et infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6231-7714","authenticated-orcid":false,"given":"Michelle S","family":"Scott","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}]}],"member":"286","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"2020010521380593300_B1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ygeno.2009.05.002","article-title":"Eukaryotic snoRNAs: a paradigm for gene expression flexibility","volume":"94","author":"Dieci","year":"2009","journal-title":"Genomics"},{"key":"2020010521380593300_B2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0955-0674(02)00334-4","article-title":"Biogenesis of small nucleolar ribonucleoproteins","volume":"14","author":"Filipowicz","year":"2002","journal-title":"Curr. 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