{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:40:40Z","timestamp":1770324040669,"version":"3.49.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701143"],"award-info":[{"award-number":["31701143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871327"],"award-info":[{"award-number":["31871327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"publisher","award":["18JCZDJC34700"],"award-info":[{"award-number":["18JCZDJC34700"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent advances in genome sequencing and functional genomic profiling have promoted many large-scale quantitative trait locus (QTL) studies, which connect genotypes with tissue\/cell type-specific cellular functions from transcriptional to post-translational level. However, no comprehensive resource can perform QTL lookup across multiple molecular phenotypes and investigate the potential cascade effect of functional variants. We developed a versatile resource, named QTLbase, for interpreting the possible molecular functions of genetic variants, as well as their tissue\/cell-type specificity. Overall, QTLbase has five key functions: (i) curating and compiling genome-wide QTL summary statistics for 13 human molecular traits from 233 independent studies; (ii) mapping QTL-relevant tissue\/cell types to 78 unified terms according to a standard anatomogram; (iii) normalizing variant and trait information uniformly, yielding &amp;gt;170 million significant QTLs; (iv) providing a rich web client that enables phenome- and tissue-wise visualization; and (v) integrating the most comprehensive genomic features and functional predictions to annotate the potential QTL mechanisms. QTLbase provides a one-stop shop for QTL retrieval and comparison across multiple tissues and multiple layers of molecular complexity, and will greatly help researchers interrogate the biological mechanism of causal variants and guide the direction of functional validation. QTLbase is freely available at http:\/\/mulinlab.org\/qtlbase.<\/jats:p>","DOI":"10.1093\/nar\/gkz888","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T07:17:54Z","timestamp":1570000674000},"page":"D983-D991","source":"Crossref","is-referenced-by-count":121,"title":["QTLbase: an integrative resource for quantitative trait loci across multiple human molecular phenotypes"],"prefix":"10.1093","volume":"48","author":[{"given":"Zhanye","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Dandan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Ke","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Yao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Zhenyang","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 999077, China"}]},{"given":"Sinan","family":"Zhai","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Hang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Hui","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Hongcheng","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 999077, China"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Xianfu","family":"Yi","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Shijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Pak Chung","family":"Sham","sequence":"additional","affiliation":[{"name":"Centre of Genomics Sciences, State Key Laboratory of Brain and Cognitive Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 999077, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-3679","authenticated-orcid":false,"given":"Mulin Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China"}]}],"member":"286","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"2020010521383002700_B1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajhg.2017.06.005","article-title":"10 Years of GWAS Discovery: biology, function, and translation","volume":"101","author":"Visscher","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"2020010521383002700_B2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","article-title":"Benefits and limitations of genome-wide association studies","volume":"20","author":"Tam","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"2020010521383002700_B3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s42003-018-0261-x","article-title":"A scientometric review of genome-wide association studies","volume":"2","author":"Mills","year":"2019","journal-title":"Commun. Biol."},{"key":"2020010521383002700_B4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrg3891","article-title":"The role of regulatory variation in complex traits and disease","volume":"16","author":"Albert","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"2020010521383002700_B5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41576-018-0016-z","article-title":"From genome-wide associations to candidate causal variants by statistical fine-mapping","volume":"19","author":"Schaid","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"2020010521383002700_B6","doi-asserted-by":"crossref","first-page":"W114","DOI":"10.1093\/nar\/gky407","article-title":"GWAS4D: multidimensional analysis of context-specific regulatory variant for human complex diseases and traits","volume":"46","author":"Huang","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/cge.13187","article-title":"Genetic association of molecular traits: a help to identify causative variants in complex diseases","volume":"93","author":"Vandiedonck","year":"2018","journal-title":"Clin. Genet."},{"key":"2020010521383002700_B8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/bib\/bbu018","article-title":"Exploring the function of genetic variants in the non-coding genomic regions: approaches for identifying human regulatory variants affecting gene expression","volume":"16","author":"Li","year":"2015","journal-title":"Brief. Bioinform."},{"key":"2020010521383002700_B9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature24277","article-title":"Genetic effects on gene expression across human tissues","volume":"550","author":"GTEx Consortium","year":"2017","journal-title":"Nature"},{"key":"2020010521383002700_B10","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cell.2018.10.022","article-title":"Impact of genetic polymorphisms on human immune cell gene expression","volume":"175","author":"Schmiedel","year":"2018","journal-title":"Cell"},{"key":"2020010521383002700_B11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13059-017-1177-3","article-title":"cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes","volume":"18","author":"Li","year":"2017","journal-title":"Genome Biol."},{"key":"2020010521383002700_B12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/bioinformatics\/btr678","article-title":"seeQTL: a searchable database for human eQTLs","volume":"28","author":"Xia","year":"2012","journal-title":"Bioinformatics"},{"key":"2020010521383002700_B13","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1089\/omi.2016.0063","article-title":"Consensus Genome-Wide expression quantitative trait loci and their relationship with human complex trait disease","volume":"20","author":"Yu","year":"2016","journal-title":"OMICS"},{"key":"2020010521383002700_B14","doi-asserted-by":"crossref","first-page":"W142","DOI":"10.1093\/nar\/gkz450","article-title":"ImmuneRegulation: a web-based tool for identifying human immune regulatory elements","volume":"47","author":"Kalayci","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41588-018-0081-4","article-title":"Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types","volume":"50","author":"Finucane","year":"2018","journal-title":"Nat. Genet."},{"key":"2020010521383002700_B16","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ng.3795","article-title":"Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types","volume":"49","author":"Chun","year":"2017","journal-title":"Nat. Genet."},{"key":"2020010521383002700_B17","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/1471-2164-15-532","article-title":"Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs","volume":"15","author":"Zhang","year":"2014","journal-title":"BMC Genomics"},{"key":"2020010521383002700_B18","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btz469","article-title":"PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations","author":"Kamat","year":"2019","journal-title":"Bioinformatics"},{"key":"2020010521383002700_B19","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nature10808","article-title":"DNase I sensitivity QTLs are a major determinant of human expression variation","volume":"482","author":"Degner","year":"2012","journal-title":"Nature"},{"key":"2020010521383002700_B20","doi-asserted-by":"crossref","first-page":"e1004663","DOI":"10.1371\/journal.pgen.1004663","article-title":"Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels","volume":"10","author":"Banovich","year":"2014","journal-title":"PLoS Genet."},{"key":"2020010521383002700_B21","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.cell.2015.08.001","article-title":"Population variation and genetic control of modular chromatin architecture in humans","volume":"162","author":"Waszak","year":"2015","journal-title":"Cell"},{"key":"2020010521383002700_B22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.cell.2015.07.048","article-title":"Genetic control of chromatin states in humans involves local and distal chromosomal interactions","volume":"162","author":"Grubert","year":"2015","journal-title":"Cell"},{"key":"2020010521383002700_B23","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.cell.2016.03.041","article-title":"Pooled ChIP-Seq Links variation in transcription factor binding to complex disease risk","volume":"165","author":"Tehranchi","year":"2016","journal-title":"Cell"},{"key":"2020010521383002700_B24","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1126\/science.aat8266","article-title":"Chromatin three-dimensional interactions mediate genetic effects on gene expression","volume":"364","author":"Delaneau","year":"2019","journal-title":"Science"},{"key":"2020010521383002700_B25","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1093\/nar\/gkx331","article-title":"Exploring genetic associations with ceRNA regulation in the human genome","volume":"45","author":"Li","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B26","doi-asserted-by":"crossref","first-page":"e1003000","DOI":"10.1371\/journal.pgen.1003000","article-title":"The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels","volume":"8","author":"Pai","year":"2012","journal-title":"PLoS Genet."},{"key":"2020010521383002700_B27","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.aad9417","article-title":"RNA splicing is a primary link between genetic variation and disease","volume":"352","author":"Li","year":"2016","journal-title":"Science"},{"key":"2020010521383002700_B28","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.1260793","article-title":"Genomic variation. Impact of regulatory variation from RNA to protein","volume":"347","author":"Battle","year":"2015","journal-title":"Science"},{"key":"2020010521383002700_B29","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.ajhg.2018.04.002","article-title":"The Post-GWAS Era: From association to function","volume":"102","author":"Gallagher","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"2020010521383002700_B30","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.cell.2016.10.026","article-title":"Genetic drivers of epigenetic and transcriptional variation in human immune cells","volume":"167","author":"Chen","year":"2016","journal-title":"Cell"},{"key":"2020010521383002700_B31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nature12223","article-title":"Variation and genetic control of protein abundance in humans","volume":"499","author":"Wu","year":"2013","journal-title":"Nature"},{"key":"2020010521383002700_B32","doi-asserted-by":"crossref","first-page":"D246","DOI":"10.1093\/nar\/gkx1158","article-title":"Expression Atlas: gene and protein expression across multiple studies and organisms","volume":"46","author":"Papatheodorou","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/nar\/29.1.308","article-title":"dbSNP: the NCBI database of genetic variation","volume":"29","author":"Sherry","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B34","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gkj144","article-title":"The UCSC Genome browser database: update 2006","volume":"34","author":"Hinrichs","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B35","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B36","doi-asserted-by":"crossref","DOI":"10.1101\/531210","article-title":"Variation across 141,456 human exomes and genomes reveals the spectrum of loss-of-function intolerance across human protein-coding genes","author":"Karczewski","year":"2019"},{"key":"2020010521383002700_B37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature15394","article-title":"An integrated map of structural variation in 2,504 human genomes","volume":"526","author":"Sudmant","year":"2015","journal-title":"Nature"},{"key":"2020010521383002700_B38","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat. Genet."},{"key":"2020010521383002700_B39","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz774","article-title":"regBase: whole genome base-wise aggregation and functional prediction for human non-coding regulatory variants","author":"Zhang","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/humu.22932","article-title":"dbNSFP v3.0: A One-Stop database of functional predictions and annotations for human nonsynonymous and Splice-Site SNVs","volume":"37","author":"Liu","year":"2016","journal-title":"Hum. Mutat."},{"key":"2020010521383002700_B41","doi-asserted-by":"crossref","first-page":"13534","DOI":"10.1093\/nar\/gku1206","article-title":"In silico prediction of splice-altering single nucleotide variants in the human genome","volume":"42","author":"Jian","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B42","doi-asserted-by":"crossref","DOI":"10.1101\/554485","article-title":"dbMTS: a comprehensive database of putative human microRNA target site SNVs and their functional predictions","author":"Li","year":"2019"},{"key":"2020010521383002700_B43","doi-asserted-by":"crossref","first-page":"D877","DOI":"10.1093\/nar\/gkv1340","article-title":"HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease","volume":"44","author":"Ward","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B44","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res."},{"key":"2020010521383002700_B45","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ajhg.2017.01.004","article-title":"InterVar: clinical interpretation of genetic variants by the 2015 ACMG-AMP Guidelines","volume":"100","author":"Li","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"2020010521383002700_B46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Roadmap\u00a0Epigenomics","year":"2015","journal-title":"Nature"},{"key":"2020010521383002700_B47","doi-asserted-by":"crossref","first-page":"D729","DOI":"10.1093\/nar\/gky1094","article-title":"Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis","volume":"47","author":"Zheng","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B48","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature13182","article-title":"A promoter-level mammalian expression atlas","volume":"507","author":"Consortium, F., the, R.P., Clst","year":"2014","journal-title":"Nature"},{"key":"2020010521383002700_B49","doi-asserted-by":"crossref","first-page":"D1062","DOI":"10.1093\/nar\/gkx1153","article-title":"ClinVar: improving access to variant interpretations and supporting evidence","volume":"46","author":"Landrum","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B50","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pinero","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2020010521383002700_B51","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nature08987","article-title":"International network of cancer genome projects","volume":"464","author":"International Cancer Genome, C.","year":"2010","journal-title":"Nature"},{"key":"2020010521383002700_B52","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/bioinformatics\/btq671","article-title":"Tabix: fast retrieval of sequence features from generic TAB-delimited files","volume":"27","author":"Li","year":"2011","journal-title":"Bioinformatics"},{"key":"2020010521383002700_B53","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1182\/blood-2015-11-682153","article-title":"Allele-specific DNA methylation reinforces PEAR1 enhancer activity","volume":"128","author":"Izzi","year":"2016","journal-title":"Blood"},{"key":"2020010521383002700_B54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ng.3737","article-title":"Identification of context-dependent expression quantitative trait loci in whole blood","volume":"49","author":"Zhernakova","year":"2017","journal-title":"Nat. Genet."},{"key":"2020010521383002700_B55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ng.3721","article-title":"Disease variants alter transcription factor levels and methylation of their binding sites","volume":"49","author":"Bonder","year":"2017","journal-title":"Nat. Genet."},{"key":"2020010521383002700_B56","doi-asserted-by":"crossref","DOI":"10.1101\/447367","article-title":"Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis","author":"V\u00f5sa","year":"2018"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/48\/D1\/D983\/31697569\/gkz888.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/48\/D1\/D983\/31697569\/gkz888.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T21:39:53Z","timestamp":1578260393000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/48\/D1\/D983\/5584691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,10]]},"references-count":56,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2019,10,10]]},"published-print":{"date-parts":[[2020,1,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkz888","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1,8]]},"published":{"date-parts":[[2019,10,10]]}}}