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So far, numerous types of defense systems have been discovered, but there is no comprehensive defense systems database to organize prokaryotic defense gene datasets. To fill this gap, we unveil the prokaryotic antiviral defense system (PADS) Arsenal (https:\/\/bigd.big.ac.cn\/padsarsenal), a public database dedicated to gathering, storing, analyzing and visualizing prokaryotic defense gene datasets. The initial version of PADS Arsenal integrates 18 distinctive categories of defense system with the annotation of 6 600 264 genes retrieved from 63,701 genomes across 33 390 species of archaea and bacteria. PADS Arsenal provides various ways to retrieve defense systems related genes information and visualize them with multifarious function modes. Moreover, an online analysis pipeline is integrated into PADS Arsenal to facilitate annotation and evolutionary analysis of defense genes. PADS Arsenal can also visualize the dynamic variation information of defense genes from pan-genome analysis. Overall, PADS Arsenal is a state-of-the-art open comprehensive resource to accelerate the research of prokaryotic defense systems.<\/jats:p>","DOI":"10.1093\/nar\/gkz916","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T11:36:44Z","timestamp":1570189004000},"page":"D590-D598","source":"Crossref","is-referenced-by-count":30,"title":["PADS Arsenal: a database of prokaryotic defense systems related genes"],"prefix":"10.1093","volume":"48","author":[{"given":"Yadong","family":"Zhang","sequence":"first","affiliation":[{"name":"National Genomics Data Center, Beijing 100101, China"},{"name":"BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Zhewen","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center, Beijing 100101, China"},{"name":"BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center, Beijing 100101, China"},{"name":"BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9917-7425","authenticated-orcid":false,"given":"Yongbing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL 32224, USA"}]},{"given":"Zaichao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biology, The University of Western Ontario, London, Ontario N6A 5B7, Canada"}]},{"given":"Jingfa","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Genomics Data Center, Beijing 100101, China"},{"name":"BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"}]}],"member":"286","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"2020071623083483700_B1","first-page":"1","article-title":"A new evolutionary law","volume":"1","author":"Valen","year":"1973","journal-title":"Evol. 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