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Genomes can be compared, analyzed and retrieved using accessions numbers of the most widely used databases including COG, KEGG ortholog, KEGG pathway, KEGG module, Pfam and InterPro. Gene annotations from multiple databases including UniProt (curated and automated protein annotations), KEGG (annotation of pathways), COG (orthology), TCDB (transporters), STRING (protein\u2013protein interactions) and InterPro (domains and signatures) can be accessed in a comprehensive overview page. Candidate effectors of the Type III secretion system (T3SS) were identified using four in silico methods. The identification of orthologs among all PVC genomes allows users to perform large-scale comparative analyses and to identify orthologs of any protein in all genomes integrated in the database. Phylogenetic relationships of PVC proteins and their closest homologs in RefSeq, comparison of transmembrane domains and Pfam domains, conservation of gene neighborhood and taxonomic profiles can be visualized using dynamically generated graphs, available for download. As a central resource for researchers working on chlamydia, chlamydia-related bacteria, verrucomicrobia and planctomyces, ChlamDB facilitates the access to comprehensive annotations, integrates multiple tools for comparative genomic analyses and is freely available at https:\/\/chlamdb.ch\/. Database URL: https:\/\/chlamdb.ch\/<\/jats:p>","DOI":"10.1093\/nar\/gkz924","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T19:30:26Z","timestamp":1570563026000},"source":"Crossref","is-referenced-by-count":12,"title":["ChlamDB: a comparative genomics database of the phylum Chlamydiae and other members of the Planctomycetes-Verrucomicrobiae-Chlamydiae superphylum"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-7929","authenticated-orcid":false,"given":"Trestan","family":"Pillonel","sequence":"first","affiliation":[{"name":"Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Bugnon 48, 1011 Lausanne, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3664-2139","authenticated-orcid":false,"given":"Florian","family":"Tagini","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Bugnon 48, 1011 Lausanne, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-8981","authenticated-orcid":false,"given":"Claire","family":"Bertelli","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Bugnon 48, 1011 Lausanne, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9529-3317","authenticated-orcid":false,"given":"Gilbert","family":"Greub","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Bugnon 48, 1011 Lausanne, Switzerland"}]}],"member":"286","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2019103013431483700_B1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tim.2014.04.013","article-title":"Chlamydia genomics: providing novel insights into chlamydial biology","volume":"22","author":"Bachmann","year":"2014","journal-title":"Trends Microbiol."},{"key":"2019103013431483700_B2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s40588-014-0005-8","article-title":"Chronic chlamydial diseases: from atherosclerosis to urogenital infections","volume":"1","author":"Leonard","year":"2014","journal-title":"Curr. 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