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Yet many mechanisms underlying bacterial pathogenesis are still poorly understood. Here, we introduce the BacFITBase database for the systematic characterization of bacterial proteins relevant for host infection aimed to enable the identification of new antibiotic targets. BacFITBase is manually curated and contains more than 90 000 entries with information on the contribution of individual genes to bacterial fitness under in vivo infection conditions in a range of host species. The data were collected from 15 different studies in which transposon mutagenesis was performed, including top-priority pathogens such as Acinetobacter baumannii and Campylobacter jejuni, for both of which increasing antibiotic resistance has been reported. Overall, BacFITBase includes information on 15 pathogenic bacteria and 5 host vertebrates across 10 different tissues. It is freely available at www.tartaglialab.com\/bacfitbase.<\/jats:p>","DOI":"10.1093\/nar\/gkz931","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T08:17:03Z","timestamp":1570522623000},"source":"Crossref","is-referenced-by-count":5,"title":["BacFITBase: a database to assess the relevance of bacterial genes during host infection"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-1047","authenticated-orcid":false,"given":"Javier Macho","family":"Rend\u00f3n","sequence":"first","affiliation":[{"name":"Systems Biology of Infection Lab, Department of Biochemistry and Molecular Biology, Biosciences Faculty, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-8380","authenticated-orcid":false,"given":"Benjamin","family":"Lang","sequence":"additional","affiliation":[{"name":"Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Dr. Aiguader 88, 08003\u00a0Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-6310","authenticated-orcid":false,"given":"Gian Gaetano","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Dr. Aiguader 88, 08003\u00a0Barcelona, Spain"},{"name":"ICREA, 23 Passeig Lluis Companys 08010 and Universitat Pompeu Fabra (UPF), 08003\u00a0Barcelona, Spain"},{"name":"Department of Biology \u2018Charles Darwin\u2019, Sapienza University of Rome, P.le A. Moro 5, Rome\u00a000185, Italy"},{"name":"Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Via Morego 30, 16163\u00a0Genoa, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6567-3474","authenticated-orcid":false,"given":"Marc Torrent","family":"Burgas","sequence":"additional","affiliation":[{"name":"Systems Biology of Infection Lab, Department of Biochemistry and Molecular Biology, Biosciences Faculty, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain"}]}],"member":"286","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"2019103013350266100_B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-04632-8","article-title":"Network biology discovers pathogen contact points in host protein-protein interactomes","volume":"9","author":"Ahmed","year":"2018","journal-title":"Nat. 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Microbiol."},{"key":"2019103013350266100_B5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nrmicro.2015.7","article-title":"The design and analysis of transposon insertion sequencing experiments","volume":"14","author":"Chao","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"2019103013350266100_B6","doi-asserted-by":"crossref","first-page":"e1003456","DOI":"10.1371\/journal.pgen.1003456","article-title":"Comprehensive assignment of roles for Salmonella Typhimurium genes in intestinal colonization of food-producing animals","volume":"9","author":"Chaudhuri","year":"2013","journal-title":"PLoS Genet."},{"key":"2019103013350266100_B7","doi-asserted-by":"crossref","first-page":"16422","DOI":"10.1073\/pnas.0906627106","article-title":"Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung","volume":"106","author":"Gawronski","year":"2009","journal-title":"Proc. Natl. Acad. Sci. 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Heal."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/advance-article-pdf\/doi\/10.1093\/nar\/gkz931\/30324767\/gkz931.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/advance-article-pdf\/doi\/10.1093\/nar\/gkz931\/30324767\/gkz931.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T18:25:46Z","timestamp":1572459946000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/advance-article\/doi\/10.1093\/nar\/gkz931\/5608989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":27,"URL":"https:\/\/doi.org\/10.1093\/nar\/gkz931","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"article-number":"gkz931"}}