{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:16:44Z","timestamp":1783055804872,"version":"3.54.6"},"reference-count":52,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"One Lambda"},{"name":"DKMS"},{"DOI":"10.13039\/100006797","name":"HistoGenetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006797","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ASHI"},{"name":"CareDX"},{"name":"EFI"},{"DOI":"10.13039\/501100005062","name":"FujireBio","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GenDX"},{"name":"LabCorp"},{"DOI":"10.13039\/100015430","name":"Anthony Nolan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015430","id-type":"DOI","asserted-by":"crossref"}]},{"name":"APHIA"},{"name":"BAG Healthcare"},{"DOI":"10.13039\/100001738","name":"Be The Match Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Marrow Donor Program"},{"name":"Inno-Train Diagnostik GmBH"},{"name":"PIRCHE"},{"DOI":"10.13039\/100012116","name":"EMBL-EBI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012116","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The IPD-IMGT\/HLA Database, http:\/\/www.ebi.ac.uk\/ipd\/imgt\/hla\/, currently contains over 25 000 allele sequence for 45 genes, which are located within the Major Histocompatibility Complex (MHC) of the human genome. This region is the most polymorphic region of the human genome, and the levels of polymorphism seen exceed most other genes. Some of the genes have several thousand variants and are now termed hyperpolymorphic, rather than just simply polymorphic. The IPD-IMGT\/HLA Database has provided a stable, highly accessible, user-friendly repository for this information, providing the scientific and medical community access to the many variant sequences of this gene system, that are critical for the successful outcome of transplantation. The number of currently known variants, and dramatic increase in the number of new variants being identified has necessitated a dedicated resource with custom tools for curation and publication. The challenge for the database is to continue to provide a highly curated database of sequence variants, while supporting the increased number of submissions and complexity of sequences. In order to do this, traditional methods of accessing and presenting data will be challenged, and new methods will need to be utilized to keep pace with new discoveries.<\/jats:p>","DOI":"10.1093\/nar\/gkz950","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T20:10:49Z","timestamp":1572379849000},"source":"Crossref","is-referenced-by-count":329,"title":["IPD-IMGT\/HLA Database"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2187-5944","authenticated-orcid":false,"given":"James","family":"Robinson","sequence":"first","affiliation":[{"name":"Anthony Nolan Research Institute, London, UK"},{"name":"UCL Cancer Institute, University College London (UCL), London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic J","family":"Barker","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Cooper","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-7955","authenticated-orcid":false,"given":"Paul","family":"Flicek","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G E","family":"Marsh","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute, London, UK"},{"name":"UCL Cancer Institute, University College London (UCL), London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"2019103104193614800_B1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1034\/j.1399-0039.2000.550314.x","article-title":"IMGT\/HLA database\u2013a sequence database for the human major histocompatibility complex","volume":"55","author":"Robinson","year":"2000","journal-title":"Tissue Antigens"},{"key":"2019103104193614800_B2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/nar\/28.1.219","article-title":"IMGT, the international ImMunoGeneTics database","volume":"28","author":"Ruiz","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2019103104193614800_B3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/nar\/29.1.210","article-title":"IMGT\/HLA Database\u2013a sequence database for the human major histocompatibility complex","volume":"29","author":"Robinson","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2019103104193614800_B4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/nar\/gkg070","article-title":"IMGT\/HLA and IMGT\/MHC: sequence databases for the study of the major histocompatibility complex","volume":"31","author":"Robinson","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2019103104193614800_B5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-60327-118-9_3","article-title":"The IMGT\/HLA database","volume":"409","author":"Robinson","year":"2007","journal-title":"Methods Mol. 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