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The Allosteric Database (ASD, available online at http:\/\/mdl.shsmu.edu.cn\/ASD) was developed ten years ago to provide comprehensive information related to allosteric regulation. In recent years, allosteric regulation has received great attention in biological research, bioengineering, and drug discovery, leading to the emergence of entire allosteric landscapes as allosteromes. To facilitate research from the perspective of the allosterome, in ASD 2019, novel features were curated as follows: (i) &gt;10\u00a0000 potential allosteric sites of human proteins were deposited for allosteric drug discovery; (ii) 7 human allosterome maps, including protease and ion channel maps, were built to reveal allosteric evolution within families; (iii) 1312 somatic missense mutations at allosteric sites were collected from patient samples from 33 cancer types and (iv) 1493 pharmacophores extracted from allosteric sites were provided for modulator screening. Over the past ten years, the ASD has become a central resource for studying allosteric regulation and will play more important roles in both target identification and allosteric drug discovery in the future.<\/jats:p>","DOI":"10.1093\/nar\/gkz958","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T15:51:12Z","timestamp":1570722672000},"source":"Crossref","is-referenced-by-count":20,"title":["Unraveling allosteric landscapes of allosterome with ASD"],"prefix":"10.1093","author":[{"given":"Xinyi","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China"},{"name":"Medicinal Bioinformatics Center, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China"}]},{"given":"Shaoyong","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related 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