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In particular, information about target regulators and the patented therapeutic agents facilitates research regarding druggability, systems pharmacology, new trends, molecular landscapes, and the development of drug discovery tools. To complement other databases, we constructed the Therapeutic Target Database (TTD) with expanded information about (i) target-regulating microRNAs and transcription factors, (ii) target-interacting proteins, and (iii) patented agents and their targets (structures and experimental activity values if available), which can be conveniently retrieved and is further enriched with regulatory mechanisms or biochemical classes. We also updated the TTD with the recently released International Classification of Diseases ICD-11 codes and additional sets of successful, clinical trial, and literature-reported targets that emerged since the last update. TTD is accessible at http:\/\/bidd.nus.edu.sg\/group\/ttd\/ttd.asp.\u00a0In case of possible web connectivity issues, two mirror sites of TTD are also constructed (http:\/\/db.idrblab.org\/ttd\/ and http:\/\/db.idrblab.net\/ttd\/).<\/jats:p>","DOI":"10.1093\/nar\/gkz981","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T19:28:51Z","timestamp":1570908531000},"source":"Crossref","is-referenced-by-count":294,"title":["Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics"],"prefix":"10.1093","author":[{"given":"Yunxia","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang\u00a0310058, China"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang\u00a0310058, China"}]},{"given":"Fengcheng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang\u00a0310058, China"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310000, China"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang\u00a0310058, China"}]},{"given":"Zhengwen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang\u00a0310058, China"}]},{"given":"Runyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang\u00a0310058, China"}]},{"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang\u00a0310058, China"}]},{"given":"Yuxiang","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang\u00a0310058, China"}]},{"given":"Ying","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, China"}]},{"given":"Chu","family":"Qin","sequence":"additional","affiliation":[{"name":"Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore\u00a0117543, Singapore"}]},{"given":"Yinghong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Chongqing University, Chongqing\u00a0401331, China"}]},{"given":"Xiaoxu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Chongqing University, Chongqing\u00a0401331, China"}]},{"given":"Yuzong","family":"Chen","sequence":"additional","affiliation":[{"name":"Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore\u00a0117543, Singapore"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-0053","authenticated-orcid":false,"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang\u00a0310058, China"}]}],"member":"286","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"key":"2019110606360717700_B1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2016.230","article-title":"A comprehensive map of molecular drug targets","volume":"16","author":"Santos","year":"2017","journal-title":"Nat. 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