{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:40:09Z","timestamp":1772120409963,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1093\/toxsci\/kfh179","type":"journal-article","created":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:43:24Z","timestamp":1086050604000},"page":"139-147","source":"Crossref","is-referenced-by-count":93,"title":["Endocrine Disruptors (Environmental Estrogens) Enhance Autoantibody Production by B1 Cells"],"prefix":"10.1093","volume":"81","author":[{"given":"Hideaki","family":"Yurino","sequence":"first","affiliation":[]},{"given":"Sho","family":"Ishikawa","sequence":"additional","affiliation":[]},{"given":"Taku","family":"Sato","sequence":"additional","affiliation":[]},{"given":"Kenji","family":"Akadegawa","sequence":"additional","affiliation":[]},{"given":"Toshihiro","family":"Ito","sequence":"additional","affiliation":[]},{"given":"Satoshi","family":"Ueha","sequence":"additional","affiliation":[]},{"given":"Hidekuni","family":"Inadera","sequence":"additional","affiliation":[]},{"given":"Kouji","family":"Matsushima","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2004,5,27]]},"reference":[{"key":"key\n\t\t\t\t20170607095855_B1","doi-asserted-by":"crossref","unstructured":"Ahmed, S. A. (2000). The immune system as a potential target for environmental estrogens (endocrine disrupters): A new emerging field. Toxicology150,191\u2013296.","DOI":"10.1016\/S0300-483X(00)00259-6"},{"key":"key\n\t\t\t\t20170607095855_B2","doi-asserted-by":"crossref","unstructured":"Ahmed, S. A., Dauphinee, M. J., Montoya, A. I. and Talal, N. (1989). Estrogen induces normal murine CD5+ B cells to produce autoantibodies J. Immunol.142,2647\u20132653.","DOI":"10.4049\/jimmunol.142.8.2647"},{"key":"key\n\t\t\t\t20170607095855_B3","doi-asserted-by":"crossref","unstructured":"Arcaro, K. F., Yi, L., Seegal, R. F., Vakharia, D. D., Yang, Y., Spink, D. C., Brosch, K., and Gierthy, J. F. (1999). 2,2\u2032,6,6\u2032-tetrachlorobiphenyl is estrogenic in vitro and in vivo. J. Cell. Biochem.72,94\u2013102.","DOI":"10.1002\/(SICI)1097-4644(19990101)72:1<94::AID-JCB10>3.0.CO;2-Y"},{"key":"key\n\t\t\t\t20170607095855_B4","doi-asserted-by":"crossref","unstructured":"Bjorksten, B. (1999). Environment and infant immunity. Proc. Nutr. Soc.58,729\u2013732.","DOI":"10.1017\/S0029665199000956"},{"key":"key\n\t\t\t\t20170607095855_B5","doi-asserted-by":"crossref","unstructured":"Burr, M., Butland, B., King, S., and Vaughan-Williams, E. (1989). Changes in asthmatic prevalence: Two surveys 15 years apart. Arch. Dis. Child.64,1452\u20131456.","DOI":"10.1136\/adc.64.10.1452"},{"key":"key\n\t\t\t\t20170607095855_B6","unstructured":"Carlsten, H., Holmdahl, R., Tarkowski, A., Nilsson, L. A. (1989). Oestradiol- and testosterone-mediated effects on the immune system in normal and autoimmune mice are genetically linked and inherited as dominant traits. Immunology68,209\u2013214."},{"key":"key\n\t\t\t\t20170607095855_B7","doi-asserted-by":"crossref","unstructured":"Cunningham, A. J. (1974). Large numbers of cells in normal mice produce antibody components of isologous erythrocytes. Nature252,749\u2013752.","DOI":"10.1038\/252749a0"},{"key":"key\n\t\t\t\t20170607095855_B8","doi-asserted-by":"crossref","unstructured":"Das, S. K., Taylor, J. A., Korach, K. S., Paria, B. C., Dey, S. K., Lubahn, D. B. (1997). Estrogenic responses in estrogen receptor-alpha deficient mice reveal a distinct estrogen signaling pathway. Proc. Natl. Acad. Sci. U.S.A.94,12786\u201312791.","DOI":"10.1073\/pnas.94.24.12786"},{"key":"key\n\t\t\t\t20170607095855_B9","doi-asserted-by":"crossref","unstructured":"Dauphinee, M., Tovar, Z., and Talal, N. (1988). B cells expressing CD5 are increased in Sj\u00f6gren's syndrome. Arthritis Rheum.31,642\u2013647.","DOI":"10.1002\/art.1780310509"},{"key":"key\n\t\t\t\t20170607095855_B10","doi-asserted-by":"crossref","unstructured":"Eaton, R. B., Schneider, G., and Schur, P. H. (1983). Enzyme immunoassay for antibodies to native DNA. Specificity and quality of antibodies. Arthrits Rheum.26,52\u201360.","DOI":"10.1002\/art.1780260109"},{"key":"key\n\t\t\t\t20170607095855_B11","doi-asserted-by":"crossref","unstructured":"Erlandsson, M. C., Jonsson, C. A., Islander, U., Ohlsson, C., Carlsten, H. (2003). Oestrogen receptor specificity in oestradiol-mediated effects on B lymphopoiesis and immunoglobulin production in male mice. Immunology108,346\u2013351.","DOI":"10.1046\/j.1365-2567.2003.01599.x"},{"key":"key\n\t\t\t\t20170607095855_B12","doi-asserted-by":"crossref","unstructured":"Forsberg, J. G. (2000). Neonatal estrogen treatment and its consequences for thymus development, serum level autoantibodies to cardiolipin, and the delayed-type hypersensitivity response. J. Toxicol. Environ. Health A60,185\u2013213.","DOI":"10.1080\/009841000156484"},{"key":"key\n\t\t\t\t20170607095855_B13","doi-asserted-by":"crossref","unstructured":"Fujimaki, H., Nohara, O., Ichinose, T., Watanabe, N., and Saito, S. (1994). IL-4 production in mediastinal lymph node cells in mice intratracheally instilled with diesel exhaust particles and antigen. Toxicology92,261\u2013268.","DOI":"10.1016\/0300-483X(94)90182-1"},{"key":"key\n\t\t\t\t20170607095855_B14","doi-asserted-by":"crossref","unstructured":"Gilmore, W., Weiner, L. P., and Correale, J. (1997). Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects. J. Immunol.158,446\u2013451.","DOI":"10.4049\/jimmunol.158.1.446"},{"key":"key\n\t\t\t\t20170607095855_B15","doi-asserted-by":"crossref","unstructured":"Grossman, C. (1984). Regulation of the immune system by sex steroids. Endocrinol. Rev.5,435\u2013454.","DOI":"10.1210\/edrv-5-3-435"},{"key":"key\n\t\t\t\t20170607095855_B16","doi-asserted-by":"crossref","unstructured":"Hardy, R. R., and Hayakawa, K. (2001). B cell developmental pathways. Annu. Rev. Immunol.19,595\u2013621.","DOI":"10.1146\/annurev.immunol.19.1.595"},{"key":"key\n\t\t\t\t20170607095855_B17","doi-asserted-by":"crossref","unstructured":"Hayakawa, K., Hardy, R. R., Parks, D. R., and Herzenberg, L. A. (1983). The \u201cLy-1 B\u201d cell subpopulations in normal, immunodefective, and autoimmune mice. J. Exp. Med.157,202\u2013218.","DOI":"10.1084\/jem.157.1.202"},{"key":"key\n\t\t\t\t20170607095855_B18","doi-asserted-by":"crossref","unstructured":"Homo-Delarche, F., Fitzpatrick, F., Christeff, N., Nunez, E. Z., Bach, J. F., Dardenne, M. (1991). Sex steroids, glucocorticoids, stress and autoimmunity. J. Steroid Biochem. Mol. Biol.40,619\u2013637.","DOI":"10.1016\/0960-0760(91)90285-D"},{"key":"key\n\t\t\t\t20170607095855_B19","doi-asserted-by":"crossref","unstructured":"Inadera, H., Hashimoto, S., Dong, H. Y., Suzuki, T., Nagai, S., Yamashita, T., Toyoda, N., and Matsushima, K. (2000). WISP-2 as a novel estrogen-responsive gene in human breast cancer cells. Biochem. Biophys. Res. Commun.275,108\u2013114.","DOI":"10.1006\/bbrc.2000.3276"},{"key":"key\n\t\t\t\t20170607095855_B20","doi-asserted-by":"crossref","unstructured":"Ishida, H., Hastings, R., Kearney, J., and Howard, M. (1992). Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells. J. Exp. Med.175,1213\u20131220.","DOI":"10.1084\/jem.175.5.1213"},{"key":"key\n\t\t\t\t20170607095855_B21","doi-asserted-by":"crossref","unstructured":"Ishida, H., Muchamuel, T., Sakaguchi, S., Andrade, S. Menon, S., and Howard, M. (1994). Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB\/W F1 mice. J. Exp. Med.179,305\u2013310.","DOI":"10.1084\/jem.179.1.305"},{"key":"key\n\t\t\t\t20170607095855_B22","doi-asserted-by":"crossref","unstructured":"Kotzin, B. L. (1996). Systemic lupus erythematosus. Cell.85,303\u2013306.","DOI":"10.1016\/S0092-8674(00)81108-3"},{"key":"key\n\t\t\t\t20170607095855_B23","doi-asserted-by":"crossref","unstructured":"Medina, K. L., Stasser, A., Kincade, P. W. (2000). Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors. Blood95,2059\u20132067.","DOI":"10.1182\/blood.V95.6.2059"},{"key":"key\n\t\t\t\t20170607095855_B24","doi-asserted-by":"crossref","unstructured":"Merucolino, T. J., Arnold, L. W., Haskins L. A., and Haughton, G. (1988). Normal mouse peritoneum contains a large population of Ly-1+ (CD5+) B cells that recognize phosphatidyl choline. J. Exp. Med.168,687\u2013698.","DOI":"10.1084\/jem.168.2.687"},{"key":"key\n\t\t\t\t20170607095855_B25","doi-asserted-by":"crossref","unstructured":"Murakami, M., Tsubata, T., Okamoto, M., Shimizu, A., Kumagai, S., Imura, H., and Honjo, T. (1992). Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature357,77\u201380.","DOI":"10.1038\/357077a0"},{"key":"key\n\t\t\t\t20170607095855_B26","doi-asserted-by":"crossref","unstructured":"Murakami, M., Tsubata, T., Shinkura, R., Nishitani, S., Okamoto, M., Yoshioka, H., Usui, T., Miyawaki, S., and Honjo, T. (1994). Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody-transgenic mice. J. Exp. Med.180,111\u2013121.","DOI":"10.1084\/jem.180.1.111"},{"key":"key\n\t\t\t\t20170607095855_B27","doi-asserted-by":"crossref","unstructured":"Murakami, M., Yoshioka, H., Shirai, T., Tsubata, T., and Honjo, T. (1995). Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells. Int. Immunol.7,877\u2013882.","DOI":"10.1093\/intimm\/7.5.877"},{"key":"key\n\t\t\t\t20170607095855_B28","doi-asserted-by":"crossref","unstructured":"Nel, A. E., Diaz-Sanchez, D., Ng, D., Hiura, T., and Saxon, A. (1998). Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J. Allergy Clin. Immunol.102,539\u2013554.","DOI":"10.1016\/S0091-6749(98)70269-6"},{"key":"key\n\t\t\t\t20170607095855_B29","doi-asserted-by":"crossref","unstructured":"Nishikawa, J., Saito, K., Goto, J., Dakeyama, F., Matsuo, M., Nishihara, T. (1999). New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator. Toxicol. Appl. Pharmacol.154,76\u201383.","DOI":"10.1006\/taap.1998.8557"},{"key":"key\n\t\t\t\t20170607095855_B30","doi-asserted-by":"crossref","unstructured":"Noller, K. L., Offord, J. R., Blair P. B., Kaufman, R. H., O'Brien, P. C., Colton T., and Melton L. J. (1988). Increased occurrence of autoimmune disease among women exposed in utero to diethylstilbestrol. Fertil. Steril.49,1080\u20131082.","DOI":"10.1016\/S0015-0282(16)59965-8"},{"key":"key\n\t\t\t\t20170607095855_B31","unstructured":"Ohno, Y. (1999). Annual Report of Research Committee on Epidemiology of Intractable Diseases. The Ministry of Health and Welfare of Japan, 246\u2013254."},{"key":"key\n\t\t\t\t20170607095855_B32","doi-asserted-by":"crossref","unstructured":"Plater-Zyberk, C., Maini, R. N., Lam, K., Kennedy, T. D., and Janossy, G. (1985). A rheumatoid arthritis B cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia. Arthritis Rheum.28,971\u2013976.","DOI":"10.1002\/art.1780280903"},{"key":"key\n\t\t\t\t20170607095855_B33","doi-asserted-by":"crossref","unstructured":"Roubinian, J. R., Talal, N., Greenspan, J. S., Goodman, J. R., and Siteri, P. K. (1978). Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies and glomerulonephritis in NZB\/NZW F1 mice. J. Exp. Med.147,1568\u20131583.","DOI":"10.1084\/jem.147.6.1568"},{"key":"key\n\t\t\t\t20170607095855_B34","unstructured":"Shirai, T., Hirose, S., Okada, T., and Nishimura, H. (1991). Immunology and immunopathology of the autoimmune disease of NZB and related mouse strains. In Immunological Disorders in Mice. E. B. Rihova and V. Vetvicka, editors. CRC Press Inc., Boca Raton, FL, 95\u2013136."},{"key":"key\n\t\t\t\t20170607095855_B35","doi-asserted-by":"crossref","unstructured":"Soto, A. M., Sonnenschein, C., Chung, K. L., Fernandez, M. F., Olea, N., Serrano, F. O. (1995). The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ. Health Perspect.103,113\u2013122.","DOI":"10.1289\/ehp.95103s7113"},{"key":"key\n\t\t\t\t20170607095855_B36","doi-asserted-by":"crossref","unstructured":"Takano, H., Yoshikawa, T., Ichinose, T., Miyabara, Y., Imaoka, K., and Sugai, M. (1997). Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am. J. Respir. Crit. Care Med.156,36\u201342.","DOI":"10.1164\/ajrccm.156.1.9610054"},{"key":"key\n\t\t\t\t20170607095855_B37","doi-asserted-by":"crossref","unstructured":"Theofilopoulos, A. N. (1985). Murine models of systemic lupus erythematosus. Adv. Immunol.37,269\u2013390.","DOI":"10.1016\/S0065-2776(08)60342-9"},{"key":"key\n\t\t\t\t20170607095855_B38","doi-asserted-by":"crossref","unstructured":"von Mutius, E. (2000). The environmental predictors of allergic disease. J. Allergy Clin. Immunol.105,9\u201319.","DOI":"10.1016\/S0091-6749(00)90171-4"},{"key":"key\n\t\t\t\t20170607095855_B39","unstructured":"Wingard, D. L., Turiel, J. (1988). Long-term effects of exposure to diethylstilbestrol. West. J. Med.149,551\u2013554."},{"key":"key\n\t\t\t\t20170607095855_B40","doi-asserted-by":"crossref","unstructured":"Wira, C. R., Sandoe, C. P. (1987). Specific IgA and IgG antibodies in the secretions of the female reproductive tract: Effects of immunization and estradiol on expression of this response in vivo. J. Immunol.138,4159\u20134164.","DOI":"10.4049\/jimmunol.138.12.4159"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/81\/1\/139\/17671884\/kfh179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T14:59:38Z","timestamp":1705157978000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfh179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,27]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,5,27]]},"published-print":{"date-parts":[[2004,9]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfh179","relation":{},"ISSN":["1096-0929","1096-6080"],"issn-type":[{"value":"1096-0929","type":"electronic"},{"value":"1096-6080","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5,27]]}}}