{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:12:11Z","timestamp":1770480731773,"version":"3.49.0"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1093\/toxsci\/kfm214","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T00:25:09Z","timestamp":1187051109000},"page":"186-196","source":"Crossref","is-referenced-by-count":104,"title":["Xenobiotic Transporters: Ascribing Function from Gene Knockout and Mutation Studies"],"prefix":"10.1093","volume":"101","author":[{"given":"Curtis D.","family":"Klaassen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,8,13]]},"reference":[{"key":"key\n\t\t\t\t20170315194116_bib1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1124\/mol.104.007393","article-title":"Role of breast cancer resistance protein (Bcrp1\/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen","volume":"67","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170315194116_bib2","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1126\/science.1093131","article-title":"Niemann-Pick C1 Lik e 1 protein is critical for intestinal cholesterol absorption","volume":"303","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170315194116_bib3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/gene.20067","article-title":"Mouse zinc transporter 1 gene provides an essential function during early embryonic development","volume":"40","year":"2004","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170315194116_bib4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1177\/153537020523001001","article-title":"Biology of a novel organic solute and steroid transporter, Ostalpha-Ostbeta","volume":"230","year":"2005","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"key\n\t\t\t\t20170315194116_bib5","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1073\/pnas.95.9.5372","article-title":"Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities","volume":"95","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1124\/mol.104.010587","article-title":"Analysis of the in vivo functions of Mrp3","volume":"68","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170315194116_bib7","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/hmg\/8.9.1665","article-title":"Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation","volume":"8","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170315194116_bib8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1053\/j.gastro.2005.10.054","article-title":"ATP7B mediates vesicular sequestration of copper: Insight into biliary copper excretion","volume":"130","year":"2006","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170315194116_bib9","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nn1288","article-title":"The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference","volume":"7","year":"2004","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170315194116_bib10","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1124\/dmd.31.11.1337","article-title":"Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats","volume":"31","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315194116_bib11","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1073\/pnas.0508483103","article-title":"Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels","volume":"103","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib12","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1073\/pnas.96.4.1716","article-title":"Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene","volume":"96","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/toxsci\/63.1.29","article-title":"Effect of phosphate transporter and methylation inhibitor drugs on the disposition of arsenate and arsenite in rats","volume":"63","year":"2001","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315194116_bib14","doi-asserted-by":"crossref","first-page":"33586","DOI":"10.1074\/jbc.M405817200","article-title":"Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis","volume":"279","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315194116_bib15","doi-asserted-by":"crossref","first-page":"33920","DOI":"10.1074\/jbc.M306370200","article-title":"Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice","volume":"278","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315194116_bib16","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1074\/jbc.M412752200","article-title":"The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter","volume":"280","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315194116_bib17","first-page":"2552","article-title":"Peptide transport by the multidrug resistance protein MRP1","volume":"61","year":"2001","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170315194116_bib18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1073\/pnas.95.1.282","article-title":"Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis","volume":"95","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib19","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1053\/gast.2001.23250","article-title":"ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism","volume":"120","year":"2001","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170315194116_bib20","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1210\/en.2006-0390","article-title":"Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice","volume":"147","year":"2006","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170315194116_bib21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","article-title":"Molecular identification of a renal urate anion exchanger that regulates blood urate levels","volume":"417","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170315194116_bib22","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1074\/jbc.M508050200","article-title":"Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice","volume":"281","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315194116_bib23","article-title":"The ABC transporter BCRP\/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction","year":"2007","journal-title":"Faseb J."},{"key":"key\n\t\t\t\t20170315194116_bib24","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1046\/j.1523-1755.2003.00274.x","article-title":"Iron handling and gene expression of the divalent metal transporter, DMT1, in the kidney of the anemic Belgrade (b) rat","volume":"64","year":"2003","journal-title":"Kidney Int."},{"key":"key\n\t\t\t\t20170315194116_bib25","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/ncpendmet0262","article-title":"Mechanisms of disease: Psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8","volume":"2","year":"2006","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"key\n\t\t\t\t20170315194116_bib26","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/sj.clpt.6100056","article-title":"Intestinal drug transporter expression and the impact of grapefruit juice in humans","volume":"81","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"key":"key\n\t\t\t\t20170315194116_bib27","doi-asserted-by":"crossref","first-page":"E1245","DOI":"10.1152\/ajpendo.00363.2001","article-title":"Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats","volume":"282","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"key\n\t\t\t\t20170315194116_bib28","first-page":"10","article-title":"Effect of microsomal enzyme inducers on biliary and urinary excretion of acetaminophen metabolites in rats. Decreased hepatobiliary and increased hepatovascular transport of acetaminophen-glucuronide after microsomal enzyme induction","volume":"18","year":"1990","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315194116_bib29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00204-003-0527-y","article-title":"The hepatocellular bile acid transporter Ntcp facilitates uptake of the lethal mushroom toxin alpha-amanitin","volume":"78","year":"2004","journal-title":"Arch. Toxicol."},{"key":"key\n\t\t\t\t20170315194116_bib30","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00424-003-1168-y","article-title":"Organic anion transporting polypeptides of the OATP\/ SLC21 family: Phylogenetic classification as OATP\/ SLCO superfamily, new nomenclature and molecular\/functional properties","volume":"447","year":"2004","journal-title":"Pflugers Arch."},{"key":"key\n\t\t\t\t20170315194116_bib31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1681\/ASN.2005090966","article-title":"Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide","volume":"18","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"key\n\t\t\t\t20170315194116_bib32","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1124\/dmd.107.014902","article-title":"Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines","volume":"35","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315194116_bib33","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1124\/mol.106.028233","article-title":"Functional involvement of multidrug resistance associated protein 4 (MRP4\/ABCC4) in the renal elimination of the anti-viral drugs, adefovir and tenofovir","volume":"71","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170315194116_bib34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.bbalip.2006.03.015","article-title":"Dietary plant sterols accumulate in the brain","volume":"1761","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170315194116_bib35","doi-asserted-by":"crossref","first-page":"15649","DOI":"10.1073\/pnas.202607599","article-title":"The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria","volume":"99","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib36","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1128\/MCB.21.16.5471-5477.2001","article-title":"Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene","volume":"21","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170315194116_bib37","doi-asserted-by":"crossref","first-page":"7902","DOI":"10.1128\/MCB.23.21.7902-7908.2003","article-title":"Deficiency in the organic cation transporters 1 and 2 (Oct1\/Oct2 [Slc22a1\/Slc22a2]) in mice abolishes renal secretion of organic cations","volume":"23","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170315194116_bib38","doi-asserted-by":"crossref","first-page":"8299","DOI":"10.1128\/MCB.25.18.8299-8310.2005","article-title":"Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues","volume":"25","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170315194116_bib39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1741-7015-2-5","article-title":"A mouse model of sitosterolemia: Absence of Abcg8\/sterolin-2 results in failure to secrete biliary cholesterol","volume":"2","year":"2004","journal-title":"BMC Med."},{"key":"key\n\t\t\t\t20170315194116_bib40","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/hep.21287","article-title":"Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency","volume":"44","year":"2006","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315194116_bib41","doi-asserted-by":"crossref","first-page":"24218","DOI":"10.1074\/jbc.M313599200","article-title":"The stem cell marker Bcrp\/ABCG2 enhances hypoxic cell survival through interactions with heme","volume":"279","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315194116_bib42","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1158\/1078-0432.CCR-06-1352","article-title":"Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics","volume":"12","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t20170315194116_bib43","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/mgme.2001.3207","article-title":"Carnitine transport by organic cation transporters and systemic carnitine deficiency","volume":"73","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"key\n\t\t\t\t20170315194116_bib44","doi-asserted-by":"crossref","first-page":"12598","DOI":"10.1021\/bi050943e","article-title":"Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice","volume":"44","year":"2005","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170315194116_bib45","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1194\/jlr.M500115-JLR200","article-title":"ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile","volume":"46","year":"2005","journal-title":"J. Lipid Res."},{"key":"key\n\t\t\t\t20170315194116_bib46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1124\/dmd.31.2.153","article-title":"The presence of xenobiotic transporters in rat placenta","volume":"31","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315194116_bib47","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1073\/pnas.092034699","article-title":"Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice","volume":"99","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib48","doi-asserted-by":"crossref","first-page":"7612","DOI":"10.1128\/MCB.24.17.7612-7621.2004","article-title":"Mrp4 confers resistance to topotecan and protects the brain from chemotherapy","volume":"24","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170315194116_bib49","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1124\/dmd.105.003780","article-title":"Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice","volume":"33","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315194116_bib50","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/hep.20898","article-title":"Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene","volume":"42","year":"2005","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315194116_bib51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2133\/dmpk.18.91","article-title":"Functional characteristics and pharmacokinetic significance of kidney-specific organic anion transporters, OAT-K1 and OAT-K2, in the urinary excretion of anionic drugs","volume":"18","year":"2003","journal-title":"Drug Metab. Pharmacokinet."},{"key":"key\n\t\t\t\t20170315194116_bib52","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbamem.2004.04.004","article-title":"Identification of phalloidin uptake systems of rat and human liver","volume":"1664","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170315194116_bib53","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1124\/dmd.106.013342","article-title":"Regional distribution of solute carrier mRNA expression along the human intestinal tract","volume":"35","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315194116_bib54","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/hep.21158","article-title":"Mrp4-\/- mice have an impaired cytoprotective response in obstructive cholestasis","volume":"43","year":"2006","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315194116_bib55","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1073\/pnas.0304987101","article-title":"Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney","volume":"101","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib56","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0090-9556(24)02969-6","article-title":"Impaired renal excretion of 6-hydroxy-5, 7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1\/ABCG2) knockout mice","volume":"32","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315194116_bib57","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1124\/jpet.106.113076","article-title":"Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices","volume":"321","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170315194116_bib58","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1124\/jpet.105.089359","article-title":"Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: In vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice","volume":"315","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170315194116_bib59","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1172\/JCI119355","article-title":"Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)","volume":"99","year":"1997","journal-title":"J. Clin. Investig."},{"key":"key\n\t\t\t\t20170315194116_bib60","doi-asserted-by":"crossref","first-page":"17923","DOI":"10.1073\/pnas.0506483102","article-title":"A human transporter protein that mediates the final excretion step for toxic organic cations","volume":"102","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib61","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/toxsci\/68.2.288","article-title":"Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats","volume":"68","year":"2002","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315194116_bib62","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/hep.21212","article-title":"Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport","volume":"44","year":"2006","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315194116_bib63","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1182\/blood-2005-04-1550","article-title":"Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake","volume":"106","year":"2005","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170315194116_bib64","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1073\/pnas.94.8.4028","article-title":"Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins","volume":"94","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib65","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1172\/JCI118214","article-title":"Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A","volume":"96","year":"1995","journal-title":"J. Clin. Investig."},{"key":"key\n\t\t\t\t20170315194116_bib66","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1074\/jbc.M207397200","article-title":"Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus","volume":"278","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315194116_bib67","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1124\/dmd.31.9.1176","article-title":"Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites","volume":"31","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315194116_bib68","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1097\/01.ASN.0000143473.64430.AC","article-title":"Contribution of multidrug resistance protein 2 (MRP2\/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter","volume":"15","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"key\n\t\t\t\t20170315194116_bib69","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1172\/JCI7963","article-title":"Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure","volume":"104","year":"1999","journal-title":"J. Clin. Investig."},{"key":"key\n\t\t\t\t20170315194116_bib70","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1210\/me.2002-0304","article-title":"Identification and characterization of novel rat and human gonad-specific organic anion transporters","volume":"17","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170315194116_bib71","doi-asserted-by":"crossref","first-page":"26934","DOI":"10.1074\/jbc.M203803200","article-title":"Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice","volume":"277","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315194116_bib72","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1172\/JCI200523915","article-title":"Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I","volume":"115","year":"2005","journal-title":"J. Clin. Investig."},{"key":"key\n\t\t\t\t20170315194116_bib73","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1210\/en.2004-0058","article-title":"Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170315194116_bib74","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1681\/ASN.V121177","article-title":"P-glycoprotein-mediated drug secretion in mouse proximal tubule perfused in vitro","volume":"12","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"key\n\t\t\t\t20170315194116_bib75","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1124\/jpet.106.101774","article-title":"Carcinogen and anticancer drug transport by Mrp2 in vivo: Studies using Mrp2 (Abcc2) knockout mice","volume":"318","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170315194116_bib76","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.hep.2003.09.037","article-title":"Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein","volume":"38","year":"2003","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315194116_bib77","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1073\/pnas.98.4.2011","article-title":"Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis","volume":"98","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170315194116_bib78","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1172\/JCI8267","article-title":"Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier","volume":"105","year":"2000","journal-title":"J. Clin. Investig."},{"key":"key\n\t\t\t\t20170315194116_bib79","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1084\/jem.188.5.797","article-title":"Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage","volume":"188","year":"1998","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170315194116_bib80","doi-asserted-by":"crossref","first-page":"F236","DOI":"10.1152\/ajprenal.00012.2004","article-title":"Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney","volume":"287","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"key\n\t\t\t\t20170315194116_bib81","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1124\/mol.106.026955","article-title":"The important role of bcrp (abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice","volume":"70","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170315194116_bib82","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1073\/pnas.0502530102","article-title":"Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception","volume":"102","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/101\/2\/186\/10997751\/kfm214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T09:29:26Z","timestamp":1737365366000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/1639031\/Xenobiotic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,13]]},"references-count":82,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,8,13]]},"published-print":{"date-parts":[[2008,2]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfm214","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,13]]}}}