{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:21:44Z","timestamp":1771478504522,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1093\/toxsci\/kfq187","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T02:14:39Z","timestamp":1277345679000},"page":"36-44","source":"Crossref","is-referenced-by-count":59,"title":["Differential Effects of Polychlorinated Biphenyl Congeners on Serum Thyroid Hormone Levels in Rats"],"prefix":"10.1093","volume":"117","author":[{"given":"Lori","family":"Martin","sequence":"first","affiliation":[]},{"given":"Curtis D.","family":"Klaassen","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2010,6,23]]},"reference":[{"key":"key\n\t\t\t\t20170315185504_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.toxlet.2009.01.030","article-title":"Effects of 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB126) on vertebral bone mineralization and on thyroxin and vitamin D levels in Sprague-Dawley rats","volume":"187","year":"2009","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170315185504_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-0773.1995.tb01004.x","article-title":"Interaction of 3,4,5,3\u2032,4\u2032-pentachlorobiphenyl and 2,4,5,2\u2032,4\u2032,5\u2032-hexachlorobiphenyl in promotion of altered hepatic foci in rats","volume":"77","year":"1995","journal-title":"Pharmacol. Toxicol."},{"key":"key\n\t\t\t\t20170315185504_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/taap.1994.1174","article-title":"Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats","volume":"128","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315185504_bib4","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1210\/endo-128-2-741","article-title":"Thyroxine and 3,3\u2032,5-triiodothyronine are glucuronidated in rat liver by different uridine diphosphate-glucuronyltransferases","volume":"128","year":"1991","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170315185504_bib5","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1289\/ehp.6809","article-title":"Relationships between PCBs and thyroid hormones and retinol in female and male polar bears","volume":"112","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170315185504_bib6","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1289\/ehp.011091163","article-title":"Differential effects of two lots of aroclor 1254 on enzyme induction, thyroid hormones, and oxidative stress","volume":"109","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170315185504_bib7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/faat.1995.1099","article-title":"Toxicity of PCB 77 (3,3\u2032,4,4\u2032-tetrachlorobiphenyl) and PCB 118 (2,3\u2032,4,4\u20325-pentachlorobiphenyl) in the rat following subchronic dietary exposure","volume":"26","year":"1995","journal-title":"Fundam. Appl. Toxicol."},{"key":"key\n\t\t\t\t20170315185504_bib8","first-page":"158","article-title":"Biliary excretion of 125I-thyroxine and fine structural alterations in the thyroid glands of Gunn rats fed polychlorinated biphenyls (PCB)","volume":"43","year":"1980","journal-title":"Lab. Invest."},{"key":"key\n\t\t\t\t20170315185504_bib9","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/0006-2952(95)02087-X","article-title":"Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats","volume":"50","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"key\n\t\t\t\t20170315185504_bib10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1006\/taap.1996.0013","article-title":"Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat","volume":"136","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315185504_bib11","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/toxsci\/68.2.372","article-title":"Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL\/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners","volume":"68","year":"2002","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib12","article-title":"Production properties and usage of polychlorinated biphenyls","volume-title":"Halogenated Biphenyls, Terphenyls, Naphthalenes and Dibenzodioxins and Related Products","year":"1989"},{"key":"key\n\t\t\t\t20170315185504_bib13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/toxsci\/47.2.158","article-title":"Effects of acute exposure to PCBs 126 and 153 on anterior pituitary and thyroid hormones and FSH isoforms in adult Sprague Dawley male rats","volume":"47","year":"1999","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib14","first-page":"49","article-title":"Symposium overview: toxicity of non-coplanar PCBs","volume":"41","year":"1998","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/toxsci\/kfj069","article-title":"Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat","volume":"90","year":"2006","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0045-6535(96)00214-7","article-title":"Comprehensive, quantitative, congener specific analyses of eight aroclors and complete PCB congener assignments on DB-1 capillary GC columns","volume":"33","year":"1996","journal-title":"Chemosphere"},{"key":"key\n\t\t\t\t20170315185504_bib17","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1021\/es903029j","article-title":"In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus)","volume":"44","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"key\n\t\t\t\t20170315185504_bib18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1006\/faat.1993.1056","article-title":"Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats\u2013assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs)","volume":"20","year":"1993","journal-title":"Fundam. Appl. Toxicol."},{"key":"key\n\t\t\t\t20170315185504_bib19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/taap.1999.8752","article-title":"Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy","volume":"160","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315185504_bib20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/toxsci\/55.1.78","article-title":"Differential effects of microsomal enzyme inducers on in vitro thyroxine (T4) and triiodothyronine (T3) glucuronidation","volume":"55","year":"2000","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/toxsci\/65.1.52","article-title":"The hypothalamo-pituitary-thyroid (HPT) axis: a target of nonpersistent ortho-substituted PCB congeners","volume":"65","year":"2002","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/019262301301418838","article-title":"Effects of microsomal enzyme inducers on thyroid follicular cell proliferation and thyroid hormone metabolism","volume":"29","year":"2001","journal-title":"Toxicol. Pathol."},{"key":"key\n\t\t\t\t20170315185504_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1081\/DCT-100100114","article-title":"Effects of TCDD on thyroid hormone homeostasis in the rat","volume":"23","year":"2000","journal-title":"Drug Chem. Toxicol."},{"key":"key\n\t\t\t\t20170315185504_bib24","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1007\/PL00000667","article-title":"The deiodinase family: selenoenzymes regulating thyroid hormone availability and action","volume":"57","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"key\n\t\t\t\t20170315185504_bib25","first-page":"71","article-title":"Consideration of enzyme and endocrine interactions in the risk assessment of PCBs","volume":"1","year":"1997","journal-title":"Rev. Toxicol."},{"key":"key\n\t\t\t\t20170315185504_bib26","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0022-3565(25)09638-7","article-title":"Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: A dose-response study","volume":"273","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170315185504_bib27","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/tx060160+","article-title":"Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1","volume":"19","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20170315185504_bib28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.pa.24.040184.000505","article-title":"Pharmacokinetics of PCBs","volume":"24","year":"1984","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"key\n\t\t\t\t20170315185504_bib29","first-page":"62","article-title":"Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260","volume":"41","year":"1998","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib31","first-page":"1","article-title":"NTP Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CAS No. 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CAS No. 57117-31-4), and 3,3\u2032,4,4\u2032,5-Pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies)","volume":"526","author":"National Toxicology Program","year":"2006","journal-title":"Natl. Toxicol. Program Tech. Rep. Ser."},{"key":"key\n\t\t\t\t20170315185504_bib32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0378-4274(93)90023-Q","article-title":"Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat","volume":"68","year":"1993","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170315185504_bib33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/10408448409023762","article-title":"Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action","volume":"13","year":"1984","journal-title":"Crit. Rev. Toxicol."},{"key":"key\n\t\t\t\t20170315185504_bib34","first-page":"47","article-title":"PCBs: structure-function relationships and mechanism of action","volume":"60","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170315185504_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/10408449409049308","article-title":"Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment","volume":"24","year":"1994","journal-title":"Crit. Rev. Toxicol."},{"key":"key\n\t\t\t\t20170315185504_bib36","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1210\/endo.138.9.5386","article-title":"Extrathyroidal effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone turnover in male Sprague-Dawley rats","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170315185504_bib37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0378-4274(95)03329-J","article-title":"Effects of gestational and lactational exposure to coplanar polychlorinated biphenyl (PCB) congeners or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thyroid hormone concentrations in weanling rats","volume":"78","year":"1995","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170315185504_bib38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/toxsci\/59.1.92","article-title":"Effects of subchronic exposure to complex mixtures of dioxin-like and non-dioxin-like polyhalogenated aromatic compounds on thyroid hormone and vitamin A levels in female Sprague-Dawley rats","volume":"59","year":"2001","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib39","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/toxsci\/65.2.184","article-title":"Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T3) and its metabolites","volume":"65","year":"2002","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib40","first-page":"50","article-title":"Promotion","volume":"81","year":"2004","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185504_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.toxlet.2003.10.025","article-title":"Tissue-specific effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the activity of 5\u2032-deiodinases I and II in rats","volume":"147","year":"2004","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170315185504_bib42","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0014-5793(93)80151-J","article-title":"Glucuronidation of thyroid hormone by human bilirubin and phenol UDP-glucuronyltransferase isoenzymes","volume":"324","year":"1993","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170315185504_bib43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2174\/138920006774832596","article-title":"Inhibition of sulfotransferases by xenobiotics","volume":"7","year":"2006","journal-title":"Curr. Drug Metab."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/117\/1\/36\/10995178\/kfq187.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T06:06:48Z","timestamp":1740204408000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/1682350\/Differential"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,23]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,6,23]]},"published-print":{"date-parts":[[2010,9]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfq187","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,23]]}}}