{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:02:33Z","timestamp":1792785753360,"version":"4.5.0"},"reference-count":47,"publisher":"China Science Publishing & Media Ltd.","issue":"9","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Science and Technology Project of Yiwu City, Zhejiang Province","award":["18-3-90"],"award-info":[{"award-number":["18-3-90"]}]}],"content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2020,8,1]]},"DOI":"10.1093\/abbs\/gmaa087","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T15:09:56Z","timestamp":1594998596000},"page":"967-974","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["NEAT1\/miR-140-3p\/MAPK1 mediates the viability and survival of coronary endothelial cells and affects coronary atherosclerotic heart disease"],"prefix":"10.3724","volume":"52","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimao","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"null","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.intimp.2014.11.013","volume":"24","author":"Lyu Y","year":"2015","unstructured":"Lyu Y, Jiang X, Dai W. The roles of a novel inflammatory neopterin in subjects with coronary atherosclerotic heart disease. Int Immunopharmacol, 2015, 24: 169-172.","journal-title":"Int Immunopharmacol"},{"key":"null","first-page":"274","volume":"36","author":"Ding H","year":"2015","unstructured":"Ding H, Dai W, Xie S, Jin D, Ning Y, Jiancheng TU. Anti-inflammatory effect and diagnostic value of serum MFG-E8 in aged coronary atherosclerotic heart disease. Med J Wuhan Univ, 2015, 36: 274-277.","journal-title":"Med J Wuhan Univ"},{"key":"null","author":"Wang L","year":"2018","unstructured":"Wang L, Li HC, Zhou J, Yang B, Qiao CD, Liu YM, Zhang Z. Correlation between the GP78 gene polymorphism and coronary atherosclerotic heart disease. Hell J Cardiol, 2018,","journal-title":"Hell J Cardiol"},{"key":"null","volume":"96","author":"Zhang Y","year":"2017","unstructured":"Zhang Y, Huang J, Yang X, Sun X, Xu Q, Wang B, Zhong P. Altered expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease. Medicine, 2017, 96:","journal-title":"Medicine"},{"key":"null","doi-asserted-by":"crossref","first-page":"S0021915017302253","DOI":"10.1016\/j.atherosclerosis.2017.05.022","volume":"263","author":"Fern\u00e1ndez-Sanl\u00e9s A","year":"2017","unstructured":"Fern\u00e1ndez-Sanl\u00e9s A, Sayols-Baixeras S, Subirana I, Degano IR, Elosua R. Association between DNA methylation and coronary heart disease or other atherosclerotic events: a systematic review. Atherosclerosis, 2017, 263:","journal-title":"Atherosclerosis"},{"key":"null","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s10266-009-0104-9","volume":"97","author":"Nakajima T","year":"2009","unstructured":"Nakajima T, Yamazaki K. Periodontal disease and risk of atherosclerotic coronary heart disease. Odontology, 2009, 97: 84-91.","journal-title":"Odontology"},{"key":"null","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12944-018-0728-2","volume":"17","author":"Wang G","year":"2018","unstructured":"Wang G, Li Y, Peng Y, Tang J, Li H. Association of polymorphisms in MALAT1 with risk of coronary atherosclerotic heart disease in a Chinese population. Lipids Health Dis, 2018, 17:","journal-title":"Lipids Health Dis"},{"key":"null","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/1008-682X.122364","volume":"16","author":"Pestell RG","year":"2014","unstructured":"Pestell RG, Yu Z. Long and noncoding RNAs (lnc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo. Asian J Androl, 2014, 16: 268-269.","journal-title":"Asian J Androl"},{"key":"null","doi-asserted-by":"crossref","first-page":"77761","DOI":"10.18632\/oncotarget.20780","volume":"8","author":"Xu M","year":"2017","unstructured":"Xu M, He Z, Ling L, Yang D, Liu G. Expression profiles analysis of long non-coding RNAs identified novel lncRNA biomarkers with predictive value in outcome of cutaneous melanoma. Oncotarget, 2017, 8: 77761-77770.","journal-title":"Oncotarget"},{"key":"null","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.18632\/oncotarget.22840","volume":"9","author":"Yang L","year":"2017","unstructured":"Yang L, Tang Y, Xiong F, He Y, Zeng Z. LncRNAs regulate cancer metastasis via binding to functional proteins. Oncotarget, 2017, 9: 1426-1443.","journal-title":"Oncotarget"},{"key":"null","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1074\/jbc.M114.610915","volume":"290","author":"Richards EJ","year":"2015","unstructured":"Richards EJ, Zhang G, Li ZP, Permuthwey J, Challa S, Li Y, Kong W. Long non-coding RNAs regulated by TGF\u03b2: lncRNA-HIT mediated TGF\u03b2-induced epithelial to mesenchymal transition in mammary epithelia. J Biol Chem, 2015, 290: 6857-6867.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"e02046","DOI":"10.7554\/eLife.02046","volume":"3","author":"Yang YW","year":"2014","unstructured":"Yang YW, Flynn RA, Yong C, Qu K, Wan B, Wang KC, Ming L. Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Elife, 2014, 3:","journal-title":"Elife"},{"key":"null","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.stem.2015.03.007","volume":"16","author":"Yin Y","year":"2015","unstructured":"Yin Y, Yan P, Lu J, Song G, Zhu Y, Li Z, Zhao Y. Opposing roles for the lncRNA haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation. Cell Stem Cell, 2015, 16: 504-516.","journal-title":"Cell Stem Cell"},{"key":"null","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.112.300849","volume":"113","author":"Leung A","year":"2013","unstructured":"Leung A, Trac C, Jin W, Lanting L, Akbany A, S\u00e6trom P, Schones DE. Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells. Circ Res, 2013, 113: 266-278.","journal-title":"Circ Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1007\/s11427-014-4698-y","volume":"57","author":"Song X","year":"2014","unstructured":"Song X, Shan D, Chen J, Jing Q. miRNAs and lncRNAs in vascular injury and remodeling. Sci China Life Sci, 2014, 57: 826-835.","journal-title":"Sci China Life Sci"},{"key":"null","first-page":"564","volume":"20","author":"Bitarafan S","year":"2018","unstructured":"Bitarafan S, Yari M, Broumand MA, Ghaderian SMH, Rahimi M, Mirfakhraie R, Azizi F. Association of increased levels of lncRNA H19 in PBMCs with risk of coronary artery disease. Cell J, 2018, 20: 564-568.","journal-title":"Cell J"},{"key":"null","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1038\/ncomms6383","volume":"5","author":"Chakravarty D","year":"2014","unstructured":"Chakravarty D, Sboner A, Nair SS, Giannopoulou E, Li R, Hennig S, Mosquera JM. The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat Commun, 2014, 5:","journal-title":"Nat Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/cam4.710","volume":"5","author":"Chai Y","year":"2016","unstructured":"Chai Y, Jie L, Zhang Z, Liu L. HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer. Cancer Med, 2016, 5: 1588-1598.","journal-title":"Cancer Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12253-016-0101-6","volume":"23","author":"Peng W","year":"2017","unstructured":"Peng W, Wang Z, Fan H. LncRNA NEAT1 impacts cell proliferation and apoptosis of colorectal cancer via regulation of Akt signaling. Pathol Oncol Res, 2017, 23: 1-6.","journal-title":"Pathol Oncol Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12894-017-0206-6","volume":"17","author":"Luu HN","year":"2017","unstructured":"Luu HN, Lin HY, S\u00f8rensen KD, Ogunwobi OO, Kumar N, Chornokur G, Phelan C. miRNAs associated with prostate cancer risk and progression. BMC Urol, 2017, 17:","journal-title":"BMC Urol"},{"key":"null","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10456-017-9545-x","volume":"20","author":"Beijnum JRV","year":"2017","unstructured":"Beijnum JRV, Giovannetti E, Poel D, Nowak-Sliwinska P, Griffioen AW. miRNAs: micro-managers of anti-cancer combination therapies. Angiogenesis, 2017, 20: 269-285.","journal-title":"Angiogenesis"},{"key":"null","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.vph.2015.02.008","volume":"71","author":"Emanueli C","year":"2015","unstructured":"Emanueli C, Shearn AI, Angelini GD, Sahoo S. Exosomes and exosomal miRNAs in cardiovascular protection and repair. Vascul Pharmacol, 2015, 71: 24-30.","journal-title":"Vascul Pharmacol"},{"key":"null","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-12-162","volume":"12","author":"Khalyfa A","year":"2014","unstructured":"Khalyfa A, Gozal D. Exosomal miRNAs as potential biomarkers of cardiovascular risk in children. J Transl Med, 2014, 12: 1-12.","journal-title":"J Transl Med"},{"key":"null","first-page":"2087","volume":"2016","author":"Karunakaran D","year":"1861","unstructured":"Karunakaran D, Rayner KJ. Macrophage miRNAs in atherosclerosis. Biochim Biophys Acta, 1861, 2016: 2087-2093.","journal-title":"Biochim Biophys Acta"},{"key":"null","doi-asserted-by":"crossref","first-page":"L460","DOI":"10.1152\/ajplung.00041.2012","volume":"303","author":"Jude JA","year":"2012","unstructured":"Jude JA, Dileepan M, Subramanian S, Solway J, Jr PR, Walseth TF, Kannan MS. miR-140-3p regulation of TNF-\u03b1-induced CD38 expression in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 2012, 303:","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","volume":"75","author":"Cargnello M","year":"2011","unstructured":"Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev, 2011, 75: 50-83.","journal-title":"Microbiol Mol Biol Rev"},{"key":"null","doi-asserted-by":"crossref","first-page":"e53006","DOI":"10.1371\/journal.pone.0053006","volume":"8","author":"Li R","year":"2013","unstructured":"Li R, Wen X, Wang S, Wu Q, Yang N, Xin Y, Pan H. Reference gene selection for qRT-PCR analysis in the sweetpotato whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae). PLos One, 2013, 8:","journal-title":"PLos One"},{"key":"null","first-page":"492","volume":"7","author":"Utermann G","year":"2010","unstructured":"Utermann G. Apolipoprotein E phenotyping from serum by western blotting. Electrophoresis, 2010, 7: 492-495.","journal-title":"Electrophoresis"},{"key":"null","first-page":"773","volume":"15","author":"Xing J","year":"2018","unstructured":"Xing J, Liu Y, Chen T. Correlations of chemokine CXCL16 and TNF-\u03b1 with coronary atherosclerotic heart disease. Exp Ther Med, 2018, 15: 773-776.","journal-title":"Exp Ther Med"},{"key":"null","doi-asserted-by":"crossref","unstructured":"Huarte M . The emerging role of lncRNAs in cancer. 2015, : 1253. 21.","DOI":"10.1038\/nm.3981"},{"key":"null","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/CIRCRESAHA.116.302521","volume":"116","author":"Uchida S","unstructured":"Uchida S, Dimmeler S. Long noncoding RNAs in cardiovascular diseases. Circ Res, 116: 737-750.","journal-title":"Circ Res"},{"key":"null","first-page":"29","volume":"394","author":"Aguilo F","year":"2015","unstructured":"Aguilo F, Cecilia SD, Walsh MJ. Long non-coding RNA ANRIL and Polycomb in human cancers and cardiovascular disease. Curr Top Microbiol Immunol, 2015, 394: 29-39.","journal-title":"Curr Top Microbiol Immunol"},{"key":"null","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10571-017-0569-y","volume":"38","author":"Yang J","year":"2018","unstructured":"Yang J, Gu L, Guo X, Huang J, Chen Z, Huang G, Kang Y. LncRNA ANRIL expression and ANRIL gene polymorphisms contribute to the risk of ischemic stroke in the Chinese Han population. Cell Mol Neurobiol, 2018, 38: 1-17.","journal-title":"Cell Mol Neurobiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1089\/dna.2016.3422","volume":"35","author":"Huang C","year":"2016","unstructured":"Huang C, Hu YW, Zhao JJ, Ma X, Zhang Y, Guo FX, Kang CM. Long noncoding RNA HOXC-AS1 suppresses Ox-LDL-induced cholesterol accumulation through promoting HOXC6 expression in THP-1 macrophages. DNA Cell Biol, 2016, 35: 722-729.","journal-title":"DNA Cell Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.molcel.2014.07.012","volume":"55","author":"West JA","year":"2014","unstructured":"West JA, Davis CP, Sunwoo H, Simon MD, Sadreyev RI, Wang PI, Tolstorukov MY. The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites. Mol Cell, 2014, 55: 791-802.","journal-title":"Mol Cell"},{"key":"null","first-page":"1020","volume":"21","author":"Zhang M","year":"2017","unstructured":"Zhang M, Wu WB, Wang ZW, Wang XH, Zhang M, Wu WB, Wang ZW. lncRNA NEAT1 is closely related with progression of breast cancer via promoting proliferation and EMT. Eur Rev Med Pharmacol Sci, 2017, 21: 1020-1026.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"null","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1109\/TCBB.2017.2776280","volume":"16","author":"Xuan Z","year":"2019","unstructured":"Xuan Z, Quan Z, Rodruguez-Paton A, Zeng X. Meta-path methods for prioritizing candidate disease miRNAs. IEEE ACM Trans Comput Biol, 2019, 16: 283-291.","journal-title":"IEEE ACM Trans Comput Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1186\/s12885-017-3776-5","volume":"17","author":"Qattan A","year":"2019","unstructured":"Qattan A, Intabli H, Alkhayal W, Eltabache C, Tweigieri T, Amer SB. Robust expression of tumor suppressor miRNA\u2019s let-7 and miR-195 detected in plasma of Saudi female breast cancer patients. BMC Cancer, 2019, 17:","journal-title":"BMC Cancer"},{"key":"null","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.hlc.2014.01.001","volume":"23","author":"Sayed ASM","year":"2014","unstructured":"Sayed ASM, Xia K, Salma U, Yang T, Peng J. Diagnosis, prognosis and therapeutic role of circulating miRNAs in cardiovascular diseases. Heart Lung Circ, 2014, 23: 503-510.","journal-title":"Heart Lung Circ"},{"key":"null","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/aps.2018.30","volume":"39","author":"Zhou S","year":"2018","unstructured":"Zhou S, Jin J, Wang J, Zhang Z, Freedman JH, Yang Z, Lu C. miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges. Acta Pharmacol Sin, 2018, 39: 1073-1084.","journal-title":"Acta Pharmacol Sin"},{"key":"null","first-page":"1629236","volume":"2016","author":"Yang L","year":"2016","unstructured":"Yang L, Fu W, Mu L, Shitao H, Song Y, Wei Y. Role of miRNAs in epicardial adipose tissue in CAD patients with T2DM. Biomed Res Int, 2016, 2016:","journal-title":"Biomed Res Int"},{"key":"null","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/MCB.00774-13","volume":"34","author":"Li J","year":"2014","unstructured":"Li J, Li Y, Jiao J, Wang J, Li Y, Qin D, Li P. Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis. Mol Cell Biol, 2014, 34: 1788-1799.","journal-title":"Mol Cell Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature08833","volume":"464","author":"Hatzivassiliou G","year":"2010","unstructured":"Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature, 2010, 464:","journal-title":"Nature"},{"key":"null","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3892\/ijmm.2014.1860","volume":"34","author":"Yang L","year":"2014","unstructured":"Yang L, Chu Y, Wang Y, Zhao X, Xu W, Zhang P, Liu X. siRNA-mediated silencing of Wnt5a regulates inflammatory responses in atherosclerosis through the MAPK\/NF-\u03baB pathways. Int J Mol Med, 2014, 34: 1147-1152.","journal-title":"Int J Mol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.biopha.2017.11.016","volume":"97","author":"Geng J","year":"2017","unstructured":"Geng J, Yang C, Wang B, Zhang X, Hu T, Gu Y, Li J. Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK\/JNK pathway. Biomed Pharmacother, 2017, 97:","journal-title":"Biomed Pharmacother"},{"key":"null","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1074\/jbc.M109.032557","volume":"285","author":"Warren DT","year":"2010","unstructured":"Warren DT, Tajsic T, Mellad JA, Searles R, Zhang Q, Shanahan CM. Novel nuclear Nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation. J Biol Chem, 2010, 285: 1311-1320.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1096\/fj.06-6752com","volume":"21","author":"Furst R","unstructured":"Furst R, Schroeder T, Eilken HM, Bubik MF, Kiemer AK, Zahler S, Vollmar AM. MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium. FASEB J, 21: 74-80.","journal-title":"FASEB J"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/86F334DC12BF4AC19C19C4DAF7C0A610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmaa087","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/abbs\/article-pdf\/52\/9\/967\/33742080\/gmaa087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/86F334DC12BF4AC19C19C4DAF7C0A610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T01:20:45Z","timestamp":1667438445000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmaa087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":47,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,8,26]]},"published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmaa087","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8,1]]}}}