{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:04:01Z","timestamp":1789322641520,"version":"build-2803163510"},"reference-count":38,"publisher":"China Science Publishing & Media Ltd.","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370955"],"award-info":[{"award-number":["81370955"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300664"],"award-info":[{"award-number":["81300664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800767"],"award-info":[{"award-number":["81800767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["18JCYBJC25500"],"award-info":[{"award-number":["18JCYBJC25500"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2021,1,1]]},"DOI":"10.1093\/abbs\/gmab002","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T12:45:49Z","timestamp":1610541949000},"page":"354-364","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C\/EBPα\/SREBP-1 pathway"],"prefix":"10.3724","volume":"53","author":[{"given":"Bo","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"null","doi-asserted-by":"publisher","first-page":"6635","DOI":"10.1074\/jbc.H118.002654","volume":"293","author":"Nickels JT","year":"2018","unstructured":"Nickels JT. New links between lipid accumulation and cancer progression. J Biol Chem, 2018, 293: 6635-6636.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.ccell.2017.11.011","volume":"32","author":"Guri Y","year":"2017","unstructured":"Guri Y, Colombi M, Dazert E, Hindupur SK, Roszik J, Moes S, Jenoe P. mTORC2 promotes tumorigenesis via lipid synthesis. Cancer Cell, 2017, 32: 807-823.","journal-title":"Cancer Cell"},{"key":"null","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1158\/0008-5472.CAN-18-2529","volume":"79","author":"Gordon JA","year":"2019","unstructured":"Gordon JA, Noble JW, Midha A, Derakhshan F, Wang G, Adomat HH, Tomlinson Guns ES. Upregulation of scavenger receptor B1 is required for steroidogenic and nonsteroidogenic cholesterol metabolism in prostate cancer. Cancer Res, 2019, 79: 3320-3331.","journal-title":"Cancer Res"},{"key":"null","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.cmet.2014.01.019","volume":"9","author":"Yue S","year":"2014","unstructured":"Yue S, Li J, Lee SY, Lee HJ, Shao T, Song B, Cheng L. Cholesteryl ester accumulation induced by PTEN loss and PI3K\/AKT activation underlies human prostate cancer aggressiveness. Cell Metab, 2014, 9: 393-406.","journal-title":"Cell Metab"},{"key":"null","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1093\/carcin\/bgy051","volume":"39","author":"Singh KB","year":"2018","unstructured":"Singh KB, Kim SH, Hahm ER, Pore SK, Jacobs BL, Singh SV. Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism. Carcinogenesis, 2018, 39: 826-837.","journal-title":"Carcinogenesis"},{"key":"null","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1073\/pnas.1808834116","volume":"116","author":"Zadra G","year":"2019","unstructured":"Zadra G, Ribeiro CF, Chetta P, Ho Y, Cacciatore S, Gao XL, Syamala S. Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. Proc Natl Acad Sci USA, 2019, 116: 631-640.","journal-title":"Proc Natl Acad Sci USA"},{"key":"null","doi-asserted-by":"publisher","first-page":"6747","DOI":"10.1158\/0008-5472.CAN-18-0585","volume":"78","author":"Penfold L","year":"2018","unstructured":"Penfold L, Woods A, Muckett P, Nikitin AY, Kent TR, Zhang S, Graham R. CAMKK2 promotes prostate cancer independently of AMPK via increased lipogenesis. Cancer Res, 2018, 78: 6747-6761.","journal-title":"Cancer Res"},{"key":"null","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1042\/BJ20131476","volume":"459","author":"Yuyama M","year":"2014","unstructured":"Yuyama M, Fujimori K. Suppression of adipogenesis by valproic acid through repression of USF1-activated fatty acid synthesis in adipocytes. Biochem J, 2014, 459: 489-503.","journal-title":"Biochem J"},{"key":"null","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/mol.113.089755","volume":"85","author":"Avery LB","year":"2014","unstructured":"Avery LB, Bumpus NN. Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice. Mol Pharmacol, 2014, 85: 1-10.","journal-title":"Mol Pharmacol"},{"key":"null","doi-asserted-by":"publisher","first-page":"21424","DOI":"10.1074\/jbc.M116.751503","volume":"291","author":"Kawashima N","year":"2016","unstructured":"Kawashima N, Nishimiya Y, Takahata S, Nakayama KI. Induction of glycosphingolipid GM3 expression by valproic acid suppresses cancer cell growth. J Biol Chem, 2016, 291: 21424-21433.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.canlet.2011.12.041","volume":"319","author":"Zapotocky M","year":"2012","unstructured":"Zapotocky M, Mejstrikova E, Smetana K, Stary J, Trka J, Starkova J. Valproic acid triggers differentiation and apoptosis in AML1\/ETO-positive leukemic cells specifically. Cancer Lett, 2012, 319: 144-153.","journal-title":"Cancer Lett"},{"key":"null","doi-asserted-by":"publisher","first-page":"4150","DOI":"10.1158\/0008-5472.CAN-10-3498","volume":"71","author":"Roos WP","year":"2011","unstructured":"Roos WP, J\u00f6st E, Belohlavek C, Nagel G, Fritz G, Kaina B. Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-\u03b2 and valproic acid. Cancer Res, 2011, 71: 4150-4160.","journal-title":"Cancer Res"},{"key":"null","doi-asserted-by":"publisher","DOI":"10.3390\/cells7090129","volume":"7","author":"Makarevi\u0107 J","year":"2018","unstructured":"Makarevi\u0107 J, Rutz J, Juengel E, Maxeiner S, Mani J, Vallo S, Tsaur I. HDAC inhibition counteracts metastatic re-activation of prostate cancer cells induced by chronic mTOR suppression. Cells, 2018, 7:","journal-title":"Cells"},{"key":"null","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.3892\/ol.2017.6580","volume":"14","author":"Liu L","year":"2017","unstructured":"Liu L, Gao H, Wang H, Zhang Y, Xu WH, Lin S, Wang HJ. Catalpol promotes cellular apoptosis in human HCT116 colorectal cancer cells via microRNA-200 and the downregulation of PI3K-Akt signaling pathway. Oncol Lett, 2017, 14: 3741-3747.","journal-title":"Oncol Lett"},{"key":"null","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.bbrc.2018.10.022","volume":"505","author":"Wang J","year":"2018","unstructured":"Wang J, Li H, Wang X, Shen T, Wang SQ, Ren DM. Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway. Biochem Biophys Res Commun, 2018, 505: 1015-1021.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.canlet.2011.07.015","volume":"311","author":"Chou YW","year":"2011","unstructured":"Chou YW, Chaturvedi NK, Ouyang S, Lin FF, Kaushik D, Wang J, Kim I. Histone deacetylase inhibitor valproic acid suppresses the growth and increases the androgen responsiveness of prostate cancer cells. Cancer Lett, 2011, 311: 177-186.","journal-title":"Cancer Lett"},{"key":"null","doi-asserted-by":"publisher","first-page":"16825","DOI":"10.1074\/jbc.R117.799973","volume":"292","author":"Xie H","year":"2017","unstructured":"Xie H, Simon MC. Oxygen availability and metabolic reprogramming in cancer. J Biol Chem, 2017, 292: 16825-16832.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1158\/2159-8290.CD-11-0102","volume":"1","author":"Guo D","year":"2011","unstructured":"Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR\/AKT\/SREBP-1\/LDLR-dependent pathway. Cancer Discov, 2011, 1: 442-456.","journal-title":"Cancer Discov"},{"key":"null","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.cell.2011.09.045","volume":"147","author":"Walker AK","year":"2011","unstructured":"Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T. A conserved SREBP-1\/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell, 2011, 147: 840-852.","journal-title":"Cell"},{"key":"null","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1021\/acs.jafc.7b00112","volume":"65","author":"Lee J","year":"2017","unstructured":"Lee J, Imm JY, Lee SH. \u03b2-Catenin mediates anti-adipogenic and anticancer effects of arctigenin in preadipocytes and breast cancer cells. J Agric Food Chem, 2017, 65: 2513-2520.","journal-title":"J Agric Food Chem"},{"key":"null","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.4161\/cc.20811","volume":"11","author":"Li WH","year":"2012","unstructured":"Li WH, Tai YH, Zhou J, Gu WT, Bai ZF, Zhou T, Zhong ZJ. Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis. Cell Cycle, 2012, 11: 2348-2358.","journal-title":"Cell Cycle"},{"key":"null","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.cmet.2012.09.002","volume":"16","author":"Shao W","year":"2012","unstructured":"Shao W, Espenshade PJ. Expanding roles for SREBP in metabolism. Cell Metab, 2012, 16: 414-419.","journal-title":"Cell Metab"},{"key":"null","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.bbrc.2013.02.030","volume":"432","author":"Qiao L","year":"2013","unstructured":"Qiao L, Wu Q, Lu X, Zhou Y, Fern\u00e1ndez-Alvarez A, Ye LH, Zang XD. SREBP-1a activation by HBx and the effect on hepatitis B virus enhancer II\/core promoter. Biochem Biophys Res Commun, 2013, 432: 643-649.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/onc.2016.265","volume":"36","author":"Li G","year":"2017","unstructured":"Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene, 2017, 36: 989-998.","journal-title":"Oncogene"},{"key":"null","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.phrs.2018.03.015","volume":"131","author":"Gomes AS","year":"2018","unstructured":"Gomes AS, Ramos H, Soares J, Saraiva L. p53 and glucose metabolism: an orchestra to be directed in cancer therapy. Pharmacol Res, 2018, 131: 75-86.","journal-title":"Pharmacol Res"},{"key":"null","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/emmm.201302734","volume":"6","author":"Zadra G","year":"2014","unstructured":"Zadra G, Photopoulos C, Tyekucheva S, Heidari P, Weng QP, Fedele G, Liu H. A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis. EMBO Mol Med, 2014, 6: 519-538.","journal-title":"EMBO Mol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1172\/JCI76029","volume":"125","author":"Dasgupta S","year":"2015","unstructured":"Dasgupta S, Putluri N, Long W, Zhang B, Wang J, Kaushik A, Arnold J. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. J Clin Invest, 2015, 125: 1174-1188.","journal-title":"J Clin Invest"},{"key":"null","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.canlet.2017.03.025","volume":"397","author":"O\u2019Malley J","year":"2017","unstructured":"O\u2019Malley J, Kumar R, Kuzmin AN, Pliss A, Yadav N, Balachandar S, Wang JM. Lipid quantification by Raman microspectroscopy as a potential biomarker in prostate cancer. Cancer Lett, 2017, 397: 52-60.","journal-title":"Cancer Lett"},{"key":"null","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41588-017-0026-3","volume":"50","author":"Chen J","year":"2018","unstructured":"Chen J, Guccini I, Mitri DD, Brina D, Revandkar A, Sarti M, Pasquini E. Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet, 2018, 50: 219-228.","journal-title":"Nat Genet"},{"key":"null","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04664-0","volume":"9","author":"Talebi A","year":"2018","unstructured":"Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, Vanderhoydonc F. Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy. Nat Commun, 2018, 9:","journal-title":"Nat Commun"},{"key":"null","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.cmet.2018.05.005","volume":"28","author":"Iwamoto H","year":"2018","unstructured":"Iwamoto H, Abe M, Yang Y, Cui D, Seki T, Nakamura M, Hosaka K. Cancer lipid metabolism confers antiangiogenic drug resistance. Cell Metab, 2018, 28: 104-117.","journal-title":"Cell Metab"},{"key":"null","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"Stockwell BR","year":"2017","unstructured":"Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell, 2017, 171: 273-285.","journal-title":"Cell"},{"key":"null","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1038\/onc.2010.30","volume":"29","author":"Pommier AJ","year":"2010","unstructured":"Pommier AJ, Alves G, Viennois E, Bernard S, Communal Y, Sion B, Marceau G. Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene, 2010, 29: 2712-2723.","journal-title":"Oncogene"},{"key":"null","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/bs.ircmb.2016.06.006","volume":"327","author":"Matsuura K","year":"2016","unstructured":"Matsuura K, Canfield K, Feng W, Kurokawa M. Metabolic regulation of apoptosis in cancer. Int Rev Cell Mol Biol, 2016, 327: 43-87.","journal-title":"Int Rev Cell Mol Biol"},{"key":"null","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1128\/MCB.06294-11","volume":"32","author":"Im SS","year":"2012","unstructured":"Im SS, Osborne TF. Protection from bacterial-toxin-induced apoptosis in macrophages requires the lipogenic transcription factor sterol regulatory element binding protein 1a. Mol Cell Biol, 2012, 32: 2196-2202.","journal-title":"Mol Cell Biol"},{"key":"null","doi-asserted-by":"publisher","first-page":"725","DOI":"10.3892\/ijmm.2015.2263","volume":"36","author":"Chen Y","year":"2015","unstructured":"Chen Y, Cai S, Wang J, Xu M. Valproic acid-induced histone acetylation suppresses CYP19 gene expression and inhibits the growth and survival of endometrial stromal cells. Int J Mol Med, 2015, 36: 725-732.","journal-title":"Int J Mol Med"},{"key":"null","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1210\/en.2005-1030","volume":"147","author":"Qiao L","year":"2006","unstructured":"Qiao L, Schaack J, Shao J. Suppression of adiponectin gene expression by histone deacetylase inhibitor valproic acid. Endocrinology, 2006, 147: 865-874.","journal-title":"Endocrinology"},{"key":"null","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10968","volume":"7","author":"Bararia D","year":"2016","unstructured":"Bararia D, Kwok HS, Welner RS, Numata A, S\u00e1rosi MB, Yang H, Wee S. Acetylation of C\/EBP\u03b1 inhibits its granulopoietic function. Nat Commun, 2016, 7:","journal-title":"Nat Commun"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/5CB03B3200654B91ADCA5C6E015DD3E6","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmab002","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/abbs\/article-pdf\/53\/3\/354\/36432600\/gmab002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/5CB03B3200654B91ADCA5C6E015DD3E6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T11:57:32Z","timestamp":1670759852000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmab002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,20]]},"published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmab002","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,1]]}}}